Diagnostic Pathology Molecular Oncology 1st edition by Mohammad Vasef , Aaron Auerbach ISBN 0323376789 ‎ 978-0323376785

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Product details:

ISBN 10: 0323376789 
ISBN 13: ‎ 978-0323376785
Author: Mohammad Vasef , Aaron Auerbach 

 This volume in the highly regarded Diagnostic Pathology seriesprovides a clearer understanding of molecular pathology as it relates to the transformation and pathogenesis of cancer. Diagnostic Pathology: Molecular Oncology is the first reference to apply a practical and clinical approach to examining how molecular mutations affect common medical diseases. Additionally, it identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies. Easy to use and packed with outstanding illustrations, this is an essential resource for all pathologists or clinicians who need to keep up with the ever-evolving field of molecular medicine.

Diagnostic Pathology: Molecular Oncology 1st  Table of contents:

Part I: Introduction to Molecular Oncology

1. Overview of Molecular Oncology
   • The Role of Molecular Pathology in Cancer Diagnosis and Treatment
   • Key Concepts in Molecular Oncology
   • Evolution of Cancer as a Genetic Disease
2. Basic Cancer Biology
   • Hallmarks of Cancer: Mutations, Oncogenes, and Tumor Suppressors
   • Cancer Cell Biology: Proliferation, Invasion, and Metastasis
   • Tumor Microenvironment and Immune Evasion

Part II: Genetic and Epigenetic Mechanisms in Cancer

3. Genetic Mutations and Cancer
   • Types of Genetic Mutations in Cancer: Point Mutations, Deletions, Amplifications
   • Oncogenes and Tumor Suppressor Genes
   • Cancer-Specific Mutations in Key Pathways (e.g., Ras, p53, BRCA)
4. Epigenetics and Cancer
   • Epigenetic Modifications in Cancer: DNA Methylation, Histone Modifications, and Non-Coding RNAs
   • Role of Epigenetic Alterations in Cancer Development and Progression
   • Epigenetic Therapeutics in Cancer
5. Genomic Instability and Cancer Progression
   • Mechanisms of Genomic Instability in Cancer
   • DNA Repair Mechanisms and Cancer Susceptibility
   • The Role of Telomeres and Telomerase in Cancer

Part III: Molecular Diagnostics in Oncology

6. Molecular Techniques in Cancer Diagnosis
   • PCR, RT-PCR, and Quantitative PCR
   • Next-Generation Sequencing (NGS) in Cancer Genomics
   • Microarray Analysis in Cancer
   • Fluorescence In Situ Hybridization (FISH) and Chromosomal Analysis
7. Biomarkers in Cancer
   • Tumor Markers: Classification and Role in Cancer Diagnosis
   • Circulating Tumor DNA (ctDNA) and Liquid Biopsy
   • Prognostic and Predictive Biomarkers in Cancer Therapy
8. Molecular Profiling of Tumors
   • Whole Exome and Whole Genome Sequencing in Cancer
   • Gene Expression Profiling in Cancer Diagnosis and Prognosis
   • Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI)
9. Personalized Medicine and Targeted Therapies
   • Introduction to Personalized Medicine in Oncology
   • Targeted Therapy Based on Molecular Profile (e.g., HER2, EGFR, ALK)
   • Case Studies of Targeted Therapies in Clinical Practice

Part IV: Molecular Pathology of Specific Cancers

10. Molecular Pathology of Solid Tumors
    • Breast Cancer: Genetic Alterations and Molecular Subtypes
    • Lung Cancer: EGFR, ALK, and KRAS Mutations
    • Colorectal Cancer: Microsatellite Instability, KRAS, and BRAF Mutations
    • Melanoma: BRAF and NRAS Mutations
    • Prostate Cancer: Genomic Alterations and Resistance Mechanisms
11. Hematological Malignancies and Molecular Pathology
    • Leukemias: Genetic and Molecular Alterations in Acute and Chronic Leukemia
    • Lymphomas: Molecular Mechanisms in Hodgkin’s and Non-Hodgkin’s Lymphoma
    • Myeloma: Genetic and Epigenetic Abnormalities
12. Molecular Oncology in Rare and Pediatric Cancers
    • Sarcomas: Genetic Alterations and Molecular Subtypes
    • Pediatric Tumors: Genetic Syndromes and Molecular Insights
    • Cancer of the Central Nervous System: Molecular Genetics in Gliomas and Medulloblastomas

Part V: Advances in Molecular Oncology

13. Cancer Immunotherapy and Molecular Mechanisms
    • Immune Checkpoint Inhibitors: PD-1/PD-L1 and CTLA-4 Inhibition
    • CAR T-Cell Therapy and Targeted Immune Approaches
    • Tumor Microenvironment and Immunotherapy Response
14. Cancer Genomics and Precision Oncology
    • Genomic Profiling in the Treatment of Cancer
    • Precision Oncology in Clinical Trials
    • Success Stories of Precision Medicine in Cancer Therapy
15. Synthetic Lethality and Targeted Cancer Treatment
    • Concept of Synthetic Lethality in Cancer
    • Exploiting DNA Repair Deficiencies for Targeted Therapy
    • Case Studies in Synthetic Lethality (e.g., PARP Inhibitors)

Part VI: Ethical, Legal, and Social Issues in Molecular Oncology

16. Ethical Issues in Molecular Oncology
    • Ethical Considerations in Genetic Testing and Personalized Cancer Therapy
    • Privacy and Data Security in Genomic Data
    • Informed Consent and Genetic Counseling
17. Regulatory and Legal Considerations
    • FDA Approval Process for Molecular Diagnostics and Targeted Therapies
    • Challenges in Regulatory Approval for Genetic and Molecular Tests
    • Legal and Insurance Issues Related to Molecular Oncology
18. Social Implications and Public Health
    • Access to Molecular Oncology Testing and Targeted Therapies
    • Health Disparities in Molecular Cancer Treatment
    • Public Perception of Genetic Testing and Personalized Medicine

Part VII: Future Directions in Molecular Oncology

19. Emerging Technologies in Cancer Genomics
    • Single-Cell Sequencing and Its Role in Cancer Research
    • Liquid Biopsy as a Tool for Early Cancer Detection and Monitoring
    • Artificial Intelligence and Machine Learning in Cancer Genomics
20. Innovative Therapeutic Strategies in Molecular Oncology
    • Development of New Targeted Therapies and Small Molecule Inhibitors
    • Advances in Gene Editing: CRISPR/Cas9 and Cancer Treatment
    • Immunotherapy Combinations and Next-Generation Cancer Vaccines
21. The Future of Molecular Oncology and Precision Medicine
    • The Role of Big Data and Genomic Databases in Cancer Research
    • Global Initiatives in Cancer Genomics
    • Predictions for the Future of Personalized Cancer Therapy

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