Diagnostic Molecular Pathology A Guide to Applied Molecular Testing 1st edition by William Coleman, Gregory Tsongalis- Ebook PDF Instant Download/Delivery. 9780128011577, 0128011572
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Product details:
ISBN 10: 0128011572
ISBN 13: 9780128011577
Author: William B. Coleman, Gregory J. Tsongalis
Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described.
The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests.
Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions.
Diagnostic Molecular Pathology A Guide to Applied Molecular Testing 1st Table of contents:
Section I: Introduction to Molecular Testing
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Chapter 1. Basic Concepts in Molecular Pathology—Introduction to Molecular Testing in Human Disease
- Topics: Mutations, Epimutations, Sources of Nucleic Acids, Disease Classification, Molecular Testing and Diagnostics, Perspectives.
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Chapter 2. Laboratory Approaches in Molecular Pathology—The Polymerase Chain Reaction
- Topics: PCR components, Optimization, Specificity, Sensitivity, Contaminants, Inhibitors, PCR variations.
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Chapter 3. Next-Generation Sequencing in the Clinical Laboratory
- Topics: DNA Sequencing Chemistry, Computer Science, Sequence Interpretation, and Clinical Reporting.
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Chapter 4. Automation of the Molecular Diagnostic Laboratory
- Topics: Automation in Nucleic Acid Extraction, Infectious Disease, Genetics, Oncology.
Section II: Molecular Testing in Infectious Disease
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Chapter 5. Molecular Testing for Human Immunodeficiency Virus
- Topics: HIV Infection, Molecular Tools for Diagnosis and Follow-Up, Clinical Situations.
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Chapter 6. Molecular Testing in Hepatitis Virus Related Disease
- Topics: HAV, HBV, HCV, HDV, HEV, GB Virus C detection.
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Chapter 7. Molecular Testing for Human Papillomaviruses
- Topics: Molecular Targets, Technologies, Clinical Utility, Limitations.
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Chapter 8. Molecular Testing for Herpes Viruses
- Topics: HSV, VZV, EBV, CMV, HHV-6, HHV-7, HHV-8.
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Chapter 9. Molecular Testing for Parvoviruses
- Topics: Parvovirus B19, Molecular Technologies, Clinical Utility.
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Chapter 10. Molecular Testing for Polyomaviruses
- Topics: Molecular Technologies, Targets, Clinical Utility, Limitations.
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Chapter 11. Molecular Testing for Respiratory Viruses
- Topics: Molecular Diagnostics, Clinical Utility, Limitations.
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Chapter 12. Molecular Testing for Diseases Associated with Bacterial Infections
- Topics: Identification, Respiratory, GI, Bloodstream Infections.
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Chapter 13. Agents Associated with Sexually Transmitted Infections
- Topics: Syphilis, Gonorrhea, Chlamydia, Mycoplasma genitalium, Trichomoniasis.
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Chapter 14. Molecular Methods for Healthcare-Acquired Infections
- Topics: MRSA, C. difficile molecular diagnostics, clinical utility.
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Chapter 15. Molecular Testing in Emerging Infectious Diseases
- Topics: Catalog of Emerging Infectious Agents, Molecular Methods.
Section III: Molecular Testing in Genetic Disease
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Chapter 16. Noninvasive Prenatal Screening (NIPS) for Fetal Aneuploidies
- Topics: Plasma Nucleic Acids, Technologies, Limitations.
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Chapter 17. Molecular Testing in Inherited Cardiomyopathies
- Topics: Major Forms of Cardiomyopathy, Molecular Targets, Technologies, Clinical Utility.
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Chapter 18. Molecular Diagnostics for Coagulopathies
- Topics: Molecular Targets, Clinical Utility, Limitations.
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Chapter 19. Molecular Diagnosis of Cystic Fibrosis
- Topics: Molecular Technologies, Clinical Utility, Limitations.
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Chapter 20. Molecular Testing in Hemochromatosis
- Topics: Disease Mechanisms, Clinical Strategies, Molecular Biology Methods.
Section IV: Molecular Testing in Oncology
- Chapter 21. Molecular Testing in Breast Cancer
- Introduction section, likely detailing molecular testing applications in breast cancer.
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