Diagnosis and Treatment of Gastroesophageal Reflux Disease 1st Edition by Michael Vaezi – Ebook PDF Instant Download/Delivery. 3319195247, 9783319195247
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ISBN 10: 3319195247
ISBN 13: 9783319195247
Author: Michael Vaezi
This volume presents the most recent developments in diagnosis and treatment of patients with gastroesophageal reflux disease (GERD) and those who continue to be refractory to conventional GERD therapies. The book delineates the role of newly developed endoscopic therapies in GERD and outlines the best candidates for surgical fundoplication. Topics as the risks associated with GERD, lifestyle modification in GERD and the role of H2RA and proton pump inhibitor therapy in treating reflux disease are also explored. Written by authorities in the field, Diagnosis and Treatment of Gastroesophageal Reflux Disease is a concise yet comprehensive resource that is useful for primary care providers, gastroenterologists, pulmonologists, surgeons and ENT specialists.
Diagnosis and Treatment of Gastroesophageal Reflux Disease 1st Table of contents:
Chapter-1
Definitions of Gastroesophageal Reflux Disease (GERD)
Spectrum of GERD
Symptom-Based Definition
Definition Based on Symptom Response to PPI
Endoscopic Definition
Ambulatory Reflux Monitoring-Based Definition: Acid Exposure Time
Impedance-Based Definition
Number of Reflux Events
Symptom–Reflux Association
Barium Radiography
Esophageal Histopathology and Mucosal Integrity
Strength of Reflux Evidence
Conclusion
References
Chapter-2
Complications of Gastroesophageal Reflux Disease
Peptic Stricture
Barrett’s Esophagus
Definition
Cellular Origin and Pathophysiology
Prevalence and Risk Factors
Esophageal Adenocarcinoma
Incidence and Risk Factors
Progression from BE to EAC
Current Endoscopic Management Approaches to BE and EAC Prevention
Screening
Surveillance
Endoscopic Therapy
Conclusion
References
Chapter-3
Diagnostic Approaches to GERD
Introduction
Proton-Pump Inhibitor Test
Provocative Testing
Radiographic Studies
Endoscopy
Esophageal Biopsy
Manometry
Ambulatory Reflux Monitoring
Ambulatory 24-h Bile Monitoring
Impedance
Conclusion
References
Chapter-4
Lifestyle Modifications in GERD
Smoking
Weight Loss
Head of Bed Elevation
Avoidance of Late-Night Meals
Breathing Exercises
Dietary Influences
Alcohol
Medications
Conclusion
References
Chapter-5
Role of H2RA and Proton Pump Inhibitor Therapy in Treating Reflux Disease
Acid Production
H2-Receptor Antagonists
Side Effects
Proton Pump Inhibitors (PPIs)
pH Control
Healing of Erosive Esophagitis and Control of Symptoms
General Treatment Approach
Nocturnal Reflux
Special Clinical Situations
Nonerosive Reflux Disease
Barrett’s Esophagus and Peptic Strictures
Extraesophageal Disease
Pregnancy
Long-Term Concerns Surrounding PPI Use
Vitamin B12 Deficiency
Hypomagnesemia
Bone Disease
Clostridium difficile Colitis
Pneumonia
Concomitant Use of PPIs and Clopidogrel
Conclusion
References
Chapter-6
Novel Upcoming Therapies
Introduction
Histamine Type 2 Receptor Antagonists
Nizatidine
Lafutidine
Lavoltidine (AH234844)
Proton Pump Inhibitors
Extended-Release PPIs
Tenatoprazole
AGN 201904-Z (Alevium)
PPI Combinations
PPI-VB101 (Vecam)
OX17
NMI-826
Secretol
PPI-Prokinetics
Rabeprazole Plus Itopride
Pantoprazole Plus Domperidone
Potassium-Competitive Acid Blockers (P-CABs)
Linaprazan (AZD 8065)
Soraprazan
Revaprazan
TAK 438
Transient Lower Esophageal Sphincter Relaxation (TLESR) Reducers
CB Receptor Agonists
CCK/Gastrin Receptors Antagonist
Prokinetics
Mosapride
Itopride
Azithromycin
Prucolopride
Reveprexide
Pumosetrag
Pain Modulators
AZD1386
Rozerem
Pregabalin
Mucosal Protectants
Bile Acid Sequestrant
IW-3718
Endoscopic Therapy
EsophyX
Medigus Ultrasonic Surgical Endostapler (MUSE)
Surgical Therapy
The LES Stimulation System (EndoStim)
References
Chapter-7
Minimally Invasive GERD Therapies
Introduction
Minimally Invasive Endoscopic (Transoral) Therapies
Stretta
The Device
The Procedure
The Data
Limitations
Summary
TF
The Device
The Procedure
The Data
Limitations
Summary
MUSE™
The Device
The Procedure
The Data
Limitations
Summary
ARMS
The Device
The Procedure
The Data
Limitations
Summary
Minimally Invasive Surgical (Laparoscopic) Therapies
Magnetic Sphincter (LINX)
The Device
The Procedure
The Data
Limitations
Summary
LES Electrical Stimulation (EndoStim)
The Device
The Procedure
The Data
Limitations
Summary
Laparoscopic Roux-en-Y Gastric Bypass
The Device
The Procedure
The Data
Limitations
Summary
Conclusion
References
Chapter-8
Role of LES Augmentation for Early Progressive Disease in GERD and Fundoplication for End-Stage Dise
Introduction
Role of LES Augmentation for Early Progressive Disease in GERD
Determining the Status of the LES
How to Identify the Patient for Sphincter Augmentation
Fundoplication for Permanent Sphincter Failure in End-Stage GERD
How to Identify the Patient for Sphincter Reconstruction
The Technique of Sphincter Reconstruction
Conclusion
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