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Diabetes and Cardiovascular Disease 2nd Edition by Michael Johnstone, Aristidis Veves ISBN 1592599087 9781592599080

Name: Diabetes and Cardiovascular Disease 2nd Edition by Michael Johnstone, Aristidis Veves ISBN 1592599087 9781592599080
SKU: EB-2296
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Original price was: $50.00.Current price is: $35.00.

Authors:Michael T. Johnstone; Aristidis Veves , Tags:(Contemporary Cardiology) , Author sort:Johnstone, Michael T. & Veves, Aristidis , Ids:Goodreads; 9780896037557 , Languages:Languages:eng , Published:Published:Jun 2001 , Publisher:Humana Press , Comments:Comments:Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease and show that 65 per cent of patients with diabetes mellitus die from a cardiovascular disease. This book comprehensively reviews both the basic and clinical aspects of diabetic vascular disease for the practising clinician.

SKU: EB-2296 Category: eBook PDF Tags: Aristidis Veves, Cardiovascular, Diabetes, Disease 2nd, Michael Johnstone

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ISBN 10: 1592599087
ISBN 13: 978-1592599080
Author: Michael T. Johnstone, Aristidis Veves

The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, “from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease” (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic retinopathy is the leading cause of new-onset blindness in working-age Americans. The importance of this text on Diabetes and Cardiovascular Disease is evident by the magnitude of the population affected by diabetes mellitus. Over 10 million Americans have been diagnosed with diabetes mellitus, while another 5 million remain undiagnosed. The impact from a public health perspective is huge and increasing. As the population of the United States grows older, more sedentary, and obese, the risk of developing diabetes and its complications will increase. Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease. Over 65% of patients with diabetes mellitus die from a cardiovascular cause. The prognosis of patients with diabetes mellitus who develop overt clinical cardiovascular disease is much worse than those cardiovascular patients free of diabetes mellitus.

Diabetes and Cardiovascular Disease 2nd Table of contents:

Effects of Insulin on the Vascular System
- Impact of insulin on endothelial cells and vascular tone
- Insulin resistance and its effects on the vascular wall
- Insulin as a mediator of vascular function
Effects of Diabetes and Insulin Resistance on Endothelial Functions
- Endothelial dysfunction in diabetes
- Mechanisms linking insulin resistance to endothelial impairment
- Role of oxidative stress in endothelial dysfunction
Diabetes and Advanced Glycoxidation End-Products (AGEs)
- Formation and accumulation of AGEs in diabetes
- Pathophysiological impact of AGEs on vascular health
- AGEs and their role in atherosclerosis and vascular complications
The Renin-Angiotensin System in Diabetic Cardiovascular Complications
- Dysregulation of the renin-angiotensin system in diabetes
- Role of Angiotensin II in promoting cardiovascular complications
- Targeting the renin-angiotensin system in diabetic vascular protection
Peroxisome Proliferator-Activated Receptors (PPARs) and Their Emerging Role in Vascular Biology, Inflammation, and Atherosclerosis
- Overview of PPARs and their functions in vascular biology
- Role of PPAR activation in inflammation and atherosclerosis in diabetes
- Therapeutic potential of PPAR agonists in diabetic cardiovascular disease
Diabetes and Thrombosis
- Prothrombotic state in diabetes
- Role of hyperglycemia, platelet dysfunction, and altered coagulation in thrombosis
- Strategies to manage thrombosis risk in diabetic patients
Role of Estrogens in Vascular Disease in Diabetes
- Effects of estrogen on vascular function in women with diabetes
- Hormonal changes and their impact on cardiovascular disease in diabetic women
- Therapeutic implications of estrogen in diabetes-related vascular disease
Poly(ADP-Ribose) Polymerase Activation and Nitrosative Stress in the Development of Cardiovascular Disease in Diabetes
- Activation of PARP and its contribution to endothelial injury
- Nitrosative stress and its role in diabetic cardiovascular complications
- Targeting PARP and nitrosative stress as therapeutic strategies
Adiponectin and the Cardiovascular System
- Adiponectin’s protective role in vascular health
- Decreased adiponectin levels in diabetes and cardiovascular risk
- Therapeutic potential of increasing adiponectin for vascular protection
Nitric Oxide and Its Role in Diabetes Mellitus
- Nitric oxide as a key regulator of vascular function
- Impaired nitric oxide production in diabetes and its effects on endothelial function
- Strategies to enhance nitric oxide bioavailability in diabetes
Diabetes and Atherosclerosis
- Mechanisms linking diabetes to atherosclerosis
- Role of hyperglycemia, lipids, and inflammation in accelerating atherosclerotic plaque formation
- Targeted therapies to prevent atherosclerosis in diabetic patients
The Use of Animal Models to Study Diabetes and Atherosclerosis and Potential Anti-Atherosclerotic Therapies
- Overview of animal models used in diabetes and cardiovascular research
- Insights from animal studies into the pathogenesis of diabetic atherosclerosis
- Potential therapies emerging from animal model research

Clinical

The Metabolic Syndrome and Vascular Disease
- Definition and components of metabolic syndrome
- Relationship between metabolic syndrome, diabetes, and cardiovascular disease
- Management strategies for metabolic syndrome to reduce cardiovascular risk
Diabetes and Hypertension
- Mechanisms linking diabetes and hypertension
- Impact of hypertension on diabetic cardiovascular complications
- Treatment strategies for managing hypertension in diabetic patients
Diabetes and Dyslipidemia
- Lipid abnormalities in diabetes: Dyslipidemia and its consequences
- Relationship between dyslipidemia and cardiovascular risk in diabetes
- Managing dyslipidemia in diabetes: Statins, fibrates, and other therapies
Diabetic Retinopathy
- Pathophysiology of diabetic retinopathy
- Impact of cardiovascular disease on diabetic retinopathy
- Screening and management strategies
Diabetic Nephropathy
- Pathophysiology of diabetic kidney disease
- Association between cardiovascular risk factors and nephropathy
- Management approaches to prevent renal and cardiovascular complications
Diabetic Neuropathy
- Mechanisms of diabetic neuropathy and its impact on the cardiovascular system
- Peripheral nerve damage and its association with vascular complications
- Managing neuropathy to reduce cardiovascular risk
Microcirculation of the Diabetic Foot
- Impact of diabetes on microvascular function in the foot
- Mechanisms of impaired circulation in diabetic foot disease
- Therapeutic strategies to improve microcirculation in the diabetic foot
Epidemiology of Peripheral Vascular Disease
- Prevalence and risk factors for peripheral vascular disease in diabetes
- Association between diabetes and peripheral artery disease (PAD)
- Epidemiological trends and public health implications
Noninvasive Methods to Assess Vascular Function and Pathophysiology
- Methods for assessing endothelial function and vascular health in diabetes
- Techniques such as ultrasound, pulse wave velocity, and ankle-brachial index (ABI)
- Utility of noninvasive tests in clinical practice
Peripheral Vascular Disease in Patients With Diabetes Mellitus
- Pathophysiology of PAD in diabetes
- Diagnostic approaches to peripheral vascular disease in diabetic patients
- Management of PAD in the context of diabetes

Therapeutic Interventions

Therapeutic Interventions to Improve Endothelial Function in Diabetes
- Pharmacological and non-pharmacological approaches to improving endothelial function
- Role of statins, ACE inhibitors, and other agents
- Exercise and lifestyle interventions
Preoperative Assessment and Perioperative Management of the Surgical Patient With Diabetes Mellitus
- Special considerations for diabetes management in the perioperative period
- Risk assessment and optimization before surgery
- Managing blood glucose and cardiovascular risks during and after surgery
Diabetes and Percutaneous Interventional Therapy
- Role of percutaneous coronary interventions (PCI) in diabetic patients
- Managing diabetes during interventional procedures
- Long-term outcomes of PCI in diabetic patients
Cardiac Surgery and Diabetes Mellitus
- Impact of diabetes on cardiac surgery outcomes
- Management strategies for diabetic patients undergoing cardiac surgery
- Postoperative care and complications
Heart Failure and Cardiac Dysfunction in Diabetes
- Pathophysiology of heart failure in diabetes
- Impact of diabetes on heart failure development and progression
- Treatment strategies for managing heart failure in diabetic patients
Diabetes Mellitus and Heart Disease
- Relationship between diabetes and various forms of heart disease
- Mechanisms linking diabetes to coronary artery disease (CAD) and heart failure
- Comprehensive management of heart disease in diabetic patients

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