Craniofacial Sutures Development, Disease and Treatment 1st Edition by David Rice ISBN 3805583265 9783805583268

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Product details:

ISBN 10:       3805583265
ISBN 13: 978-3805583268
Author:         David P. Rice

Sutures are more than just fibrous joints between the bones in our skull. They are active growth sites that influence the development, growth and shaping of our face and cranium. When suture development is disrupted, craniosynostosis can result, a condition which is characterized by the premature closure of one or more cranial sutures before brain growth is complete and leads to an abnormally shaped skull. In this publication, leading experts in the field, both researchers and clinicians, discuss suture morphogenesis from developmental, evolutionary and genetic perspectives. In addition, an appraisal of the molecular etiology, clinical presentation and treatment of craniosynostosis is presented, as well as an outlook to future areas of study and to innovative therapeutic philosophies.

In this volume craniofacial developmental and evolutionary biologists, oral and maxillofacial surgeons, orthodontists as well as pediatric and plastic surgeons will find a wealth of recent information on the field of craniofacial development, deformity and its treatment.

Craniofacial Sutures- Development, Disease and Treatment 1st Table of contents:

Part I: Introduction to Craniofacial Sutures

1. Overview of Craniofacial Sutures

   • Definition and Function
   • Embryological Origins
   • Clinical Significance

2. Anatomy of Craniofacial Sutures

   • Key Sutures of the Skull
   • Structural and Cellular Composition
   • Biomechanical Properties

3. Evolutionary Perspectives

   • Comparative Anatomy in Vertebrates
   • Role in Cranial Morphology

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Part II: Development and Growth of Sutures

4. Molecular Mechanisms of Suture Development

   • Genetic Pathways and Signaling Molecules
   • Role of Neural Crest Cells

5. Postnatal Suture Growth

   • Factors Influencing Growth and Maturation
   • Suture Patency vs. Fusion

6. Mechanobiology of Sutures

   • Response to Mechanical Forces
   • Influence on Skull Shape and Function

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Part III: Craniofacial Disorders Involving Sutures

7. Craniosynostosis: Etiology and Pathophysiology

   • Genetic and Environmental Causes
   • Classification and Phenotypic Variability

8. Syndromic vs. Non-Syndromic Craniosynostosis

   • Common Syndromes (e.g., Apert, Crouzon, Pfeiffer)
   • Diagnostic Criteria

9. Suture Abnormalities Beyond Craniosynostosis

   • Delayed Suture Closure
   • Hyperostosis and Hypoplasia

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Part IV: Diagnosis and Treatment Approaches

10. Diagnostic Techniques for Suture-Related Disorders

    • Imaging Modalities (CT, MRI, Ultrasound)
    • Genetic Testing and Biomarkers

11. Surgical Interventions

    • Traditional Approaches (Cranial Vault Remodeling)
    • Minimally Invasive Techniques

12. Non-Surgical and Adjunct Therapies

    • Orthodontic and Orthopedic Interventions
    • Pharmacological Treatments

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Part V: Research and Future Directions

13. Advances in Molecular and Cellular Research

    • Novel Insights into Suture Biology
    • Emerging Therapeutic Targets

14. Regenerative Medicine and Tissue Engineering

    • Biomaterials and Scaffold-Based Approaches
    • Stem Cell Applications

15. Computational Modeling and Biomechanics

    • Predictive Models for Suture Behavior
    • Simulation of Growth and Surgical Outcomes

16. Ethical and Societal Implications

    • Addressing Accessibility and Equity in Treatment
    • Long-Term Follow-Up and Quality of Life

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