Contemporary Oral Oncology Diagnosis and Management 1st Edition by Moni Abraham Kuriakose ISBN 3319149113 9783319149110

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Product details:

ISBN 10: 3319149113

ISBN 13: 9783319149110

Author:  Moni Abraham Kuriakose 

Contemporary Oral Oncology: Diagnosis and Management 1st Edition: 

This is the first of four volumes that together offer an authoritative, in-depth reference guide covering all aspects of the management of oral cancer from a multidisciplinary perspective and on the basis of a strong scientific foundation. This volume, on tumor biology, epidemiology, etiology, emerging role of cancer stem cells and prevention of oral cancer, opens by discussing oral carcinogenesis in general and the role of particular carcinogens and human papillomavirus. Global epidemiology and changes in disease prevalence are then addressed. Up-to-date information is provided on emerging cancer biomarkers, and the biologic basis of personalized therapy is explained. Histopathological features of malignant and premalignant neoplasms and their relevance to management are described. Further chapters focus on the current status of chemoprevention, the management of oral submucous fibrosis, and the value of various diagnostic adjuncts. The volume concludes by critically evaluating theefficacy of oral screening methods.

Volume 1: Biology, Epidemiology, Etiology, and Prevention

Volume 2: Diagnosis and Management

Volume 3: Oral and Maxillofacial Reconstructive Surgery

Volume 4: Rehabilitation and Supportive Care

 

Contemporary Oral Oncology: Diagnosis and Management 1st Edition Table of contents:

1: Carcinogenesis and Field Cancerization in Oral Squamous Cell Carcinoma

• 1.1 Oral Carcinogenesis
  • 1.1.1 Clinical Progression of Oral Cancer
    • Potentially Malignant Lesions
  • 1.1.2 Histological Progression
  • 1.1.3 Molecular Model of Progression
  • 1.1.4 Biomarkers of Oral Carcinogenesis
    • Tumor Suppressor Genes (TSG)
    • Cell Cycle and Proliferation Markers
    • Angiogenesis and Metastatic Markers
    • Cytokeratins
    • miRNA Markers
  • 1.1.5 Cancer Stem Cells in Oral Carcinogenesis
  • 1.1.6 Markers of Oral Carcinogenesis: Implications in Early Detection and Chemoprevention
• 1.2 Field Cancerization in Oral Cancer
  • Cellular Basis of Field Cancerization
  • Molecular Models of Field Cancerization
  • Biomarkers of Field Cancerization
    • TP53 Mutations
    • Loss of Heterozygosity
    • Telomerase
    • Ploidy Analysis
    • Angiogenesis Markers
    • Other Markers
  • Cancer Stem Cells in Field Cancerization
    • Implication of Field Cancerization in Diagnosis and Therapy in Oral Cancer
    • Definition of Terminology
• References

2: Aetiology of Oral Cavity Cancer

• Introduction
• The Theory of Carcinogenesis (See Vol. I, Chap. 1 for Details)
• Epidemiology of Oral Cancer (See Vol. I, Chap. 4 for More Details)
• Oral Potentially Malignant Disorders (See Vol. I, Chap. 10 for More Details)
• Clinical Presentation of OSCC and OPML
• 2.6 Risk Factors for OSCC
  • Tobacco
    • Cigarette and Cigars
    • Smokeless Tobacco
    • Waterpipe Smoking
    • Areca Nut/Betel Quid
  • Alcohol
    • Epidemiological Evidence
    • Molecular Mechanisms of Genotoxicity
    • Acetaldehyde
    • DNA Adducts from Acetaldehyde
    • Chromosomal and DNA Damage
    • Induction of CYP2E1
    • Oxidative Stress
    • Lipid Peroxidation
    • Enhanced Penetration of Carcinogens
  • Alcohol-Containing Mouthwashes
    • Epidemiological Evidence
    • Mechanistic Evidence
    • Unifying Hypothesis
  • Microorganisms
    • Human Papillomavirus
    • Candida
  • Diet
• Immune Deficiency and Transplantation
• Genetics, Syndromes, and DNA Repair Defects
• UV and Lip Cancer
• References

3: Human Papillomaviruses and Squamous Cell Carcinomas of Head and Neck Region

• HPV Genome and Proteome
• Biology of HPV
• Molecular Pathology of HPV Carcinogenesis
• HPV-Associated Oral Diseases: Diverse Manifestations
• Epidemiology of HPV in HNSCC
• Clinical Outcomes in HPV-Associated HNC
• HPV Detection in Clinical Samples
• HPV Vaccinology
• Therapeutic Vaccines
• Future Perspectives

 

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