Clinical pharmacology 12th Edition by Morris Brown, Pankaj Sharma, Fraz Mir, Peter Bennett ISBN 9780702073311 0702073318

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ISBN 10: 0702073318
ISBN 13: 9780702073311
Author: Morris Brown, Pankaj Sharma, Fraz Mir, Peter Bennett 

‘The very last thing a drug regulator wishes to be able to say is, like Lord Byron (1788-1824), on the publication of his poem Childe Harold’s Pilgrimage, ‘I awoke one morning and found myself famous.’

The twelfth edition of this long-established textbook of clinical pharmacology (first published in 1960) continues its fine tradition of balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy.

• Coverage of all major therapeutic topics by body system.
• Introductory sections give brief chapter synopses.
• Case studies where relevant.
• Covers the needs of the developing world with a focus on practical prescribing and health technology assessment.
• Definition, tips, brief explanation boxes throughout.
• Interesting histories, etymologies and provenances of terms throughout.
• Entertaining footnotes throughout.
• Fully updated throughout.
• New co-editor: Fraz Mir, Addenbrooke’s Hospital and Department of Medicine, University of Cambridge.
• Now with free e-book on StudentConsult.

Clinical pharmacology 12th Edition Table of contents:

Section 1 General

Introduction

Chapter 1 Clinical pharmacology

Guide to further reading

Chapter 2 Topics in drug therapy

The therapeutic situation

Treating patients with drugs

Physician-induced (iatrogenic) disease

Benefits and risks of medicines

Public view of drugs and prescribers

Criticisms of modern drugs

Drug-induced injury (see also Ch. 9)

Complementary, alternative and traditional medicine

Placebo medicines

Guidelines, ‘essential’ drugs and prescribing

Compliance

Pharmacoeconomics (see also Ch. 5)

Guide to further reading

Appendix: the prescription

Weights and measures

Percentages, proportions, weight in volume

Chapter 3 Discovery and development of drugs

Making a new medicine

Techniques of discovery

Drug quality

Studies in animals

Ethics and legislation

Safety prediction

Orphan drugs and diseases

Guide to further reading

Chapter 4 Evaluation of drugs in humans

Experimental therapeutics

Rational introduction of a new drug to humans

Need for statistics

Types of therapeutic trial

Meta-analysis

Results: implementation

Pharmacoepidemiology

Strength of evidence

Guide to further reading

Chapter 5 Health technology assessment

The scope

Clinical effectiveness

Cost-effectiveness

In conclusion

Guide to further reading

Chapter 6 Regulation of medicines

Basis for regulation

Current medicines regulatory systems

Requirements

Regulatory review

Post-licensing responsibilities

Discussion

Licensed medicines for unlicensed indications

Unlicensed medicines and accelerated licensing

Decision-taking

Guide to further reading

Chapter 7 Classification and naming of drugs

Classification

Nomenclature (names)

Guide to further reading

Section 2 From pharmacology to toxicology

Introduction

Chapter 8 General pharmacology

Pharmacodynamics

Pharmacokinetics

Individual pharmacokinetic processes

Chronic pharmacology

Individual or biological variation

Examples of pharmacogenomic variation

Environmental and host influences

Drug interactions

Guide to further reading

Chapter 9 Unwanted effects and adverse drug reactions

Background

Definitions

Attribution and degrees of certainty

Pharmacovigilance and pharmacoepidemiology

Sources of adverse drug reactions

Allergy in response to drugs

Miscellaneous adverse reactions

Effects of prolonged administration: chronic organ toxicity

Adverse effects on reproduction

Male reproductive function

Guide to further reading

Chapter 10 Poisoning, overdose, antidotes

Introduction

Initial assessment

Resuscitation

Supportive treatment

Preventing further absorption of the poison

Accelerating elimination of the poison

Specific antidotes

Psychiatric and social assessment

Poisoning by (non-drug) chemicals

Poisoning by biological substances

Guide to further reading

Chapter 11 Drug dependence

Introduction

Definitions

General patterns of use

Sites and mechanisms of action

Route of administration and effect

Prescribing for drug dependence

Treatment of dependence

Mortality

Escalation

Novel psychoactive substances

Drugs and sport

Types of drug dependence

Ethyl alcohol (ethanol)

Tobacco

Psychodysleptics or hallucinogens

Psychostimulants

Volatile substance abuse

Guide to further reading

Section 3 Infection and inflammation

Introduction

Chapter 12 Chemotherapy of infections

History

Classification of antimicrobial drugs

How antimicrobials act – sites of action

Principles of antimicrobial chemotherapy

Use of antimicrobial drugs

Problems with antimicrobial drugs

Drugs of choice

Guide to further reading

Chapter 13 Antibacterial drugs

Classification

Inhibition of cell wall synthesis

Inhibition of protein synthesis

Inhibition of nucleic acid synthesis

Guide to further reading

Chapter 14 Chemotherapy of bacterial infections

Infection of the blood

Infection of paranasal sinuses and ears

Infection of the throat

Infection of the bronchi, lungs and pleura

Endocarditis

Meningitis

Infection of the intestines

Infection of the urinary tract

Genital tract infections

Infection of bones and joints

Eye infections

Mycobacterial infections

Guide to further reading

Chapter 15 Viral, fungal, protozoal and helminthic infections

Viral infections

Fungal infections

Protozoal infections

Helminthic infections

Guide to further reading

Chapter 16 Drugs for inflammation and joint disease

Introduction

Inflammation

Pharmacological manipulation of inflammatory mediators

Immunomodulatory drugs

Biologic agents

Management of diseases affecting the joints

Guide to further reading

Chapter 17 Drugs and the skin

Dermal pharmacokinetics

Cutaneous drug reactions

Individual disorders

Guide to further reading

Section 4 Nervous system

Introduction

Chapter 18 Pain and analgesics

Pain and analgesics

Pharmacotherapy

Non-opioid analgesics

Opioid analgesics

Pharmacology of individual opioids

Tolerance, dependence and addiction

Co-analgesics

Pharmacotherapy of acute migraine headaches

Guide to further reading

Chapter 19 Anaesthesia and neuromuscular block

General anaesthesia

Pharmacology of anaesthetics

Inhalation anaesthetics

Intravenous anaesthetics

Muscle relaxants

Local anaesthetics

Obstetric analgesia and anaesthesia

Anaesthesia in patients already taking medication

Anaesthesia in the diseased, and in particular patient groups

Guide to further reading

Chapter 20 Psychotropic drugs

Antidepressant drugs

Antipsychotics

Mood stabilisers

Drugs used in anxiety and sleep disorders

Classification of anxiety disorders

Drugs for Alzheimer’s disease (dementia)

Drugs in attention deficit/hyperactivity disorder

Drugs for psychiatric illness in childhood

Guide to further reading

Chapter 21 Neurological disorders – epilepsy, Parkinson’s disease and multiple sclerosis

Epilepsy

Other movement disorders

Multiple sclerosis

Miscellaneous neurological disorders

Guide to further reading

Section 5 Cardiorespiratory and renal systems

Introduction

Chapter 22 Cholinergic and antimuscarinic (anticholinergic) mechanisms and drugs

Cholinergic drugs (cholinomimetics)

Drugs that oppose acetylcholine

Guide to further reading

Chapter 23 Adrenergic mechanisms and drugs

Adrenergic mechanisms

Classification of sympathomimetics

Individual sympathomimetics

Mucosal decongestants

Shock

Chronic orthostatic hypotension

Detrusor relaxation for urinary frequency, urgency and urge incontinence

Guide to further reading

Chapter 24 Arterial hypertension, angina pectoris, myocardial infarction and heart failure

Hypertension: how drugs act

Angina pectoris: how drugs act

Drugs used in hypertension and angina

Drug treatment of angina, myocardial infarction and hypertension

Heart failure and its treatment

Guide to further reading

Chapter 25 Cardiac arrhythmia

Classification of antiarrhythmic drugs

Principal drugs by class

Specific treatments

Guide to further reading

Chapter 26 Hyperlipidaemias

Guide to further reading

Chapter 27 Kidney and genitourinary tract

Diuretic drugs

Individual diuretics

Indications for diuretics

Carbonic anhydrase inhibitors

Cation-exchange compounds

Alteration of urine pH

Drugs and the kidney

Prescribing in renal disease

Nephrolithiasis

Pharmacological aspects of micturition

Benign prostatic hyperplasia (BPH)

Erectile dysfunction

Guide to further reading

Chapter 28 Respiratory system

Cough

Respiratory stimulants

Pulmonary surfactant

Oxygen therapy

Histamine, antihistamines and allergies

Bronchial asthma

Chronic obstructive pulmonary disease (COPD)

Guide to further reading

Section 6 Blood and neoplastic disease

Introduction

Chapter 29 Drugs and haemostasis

The coagulation system

Fibrinolytic (thrombolytic) system

Platelet function

Guide to further reading

Chapter 30 Red blood cell disorders

Iron

Vitamin B12

Folic acid (pteroylglutamic acid)

Haemolytic anaemia

Haemoglobinopathies

Aplastic anaemia

Polycythaemia vera

Haemopoietic growth factors

Thrombopoietin receptor agonists

Guide to further reading

Chapter 31 Neoplastic disease and immunosuppression

Neoplastic disease

Immunosuppression

Guide to further reading

Section 7 Gastrointestinal system

Introduction

Chapter 32 Oesophagus, stomach and duodenum

The oesophagus in health and disease

Gastric acid secretion and mucosal protection

Drugs affecting oesophageal motility and the lower oesophageal sphincter

Drugs to reduce or neutralise gastric acid

Drugs to enhance mucosal protection

Pharmacological management

Nausea and vomiting

Non-ulcer dyspepsia and functional disorders

Guide to further reading

Chapter 33 Intestines

Diarrhoea

Constipation

Inflammatory bowel disease (IBD)

Irritable bowel syndrome (IBS)

Gastroparesis

Diverticular disease

Anal fissure

Guide to further reading

Chapter 34 Liver and biliary tract

Effects of liver disease

Guide to further reading

Section 8 Endocrine system, metabolic conditions

Introduction

Chapter 35 Adrenal corticosteroids, antagonists, corticotropin

Adrenal steroids and their synthetic analogues

Uses of adrenocortical steroids

Inhibition of synthesis of adrenal and other steroid hormones

Competitive antagonism of adrenal steroids

Adrenocorticotrophic hormone (ACTH) (corticotropin)

Guide to further reading

Chapter 36 Diabetes mellitus, insulin, oral antidiabetes agents, obesity

Diabetes overview

History of insulin therapy in diabetes

Uses

Non-insulin antidiabetes drugs

Surgery in diabetic patients

Diabetic ketoacidosis

Preventing complications other than by glucose lowering

Obesity and appetite control

Guide to further reading

Chapter 37 Thyroid hormones, antithyroid drugs

Thyroid hormones

Levothyroxine for hypothyroidism

Antithyroid drugs and hyperthyroidism

Drugs that cause hypothyroidism

Drugs causing either hyper- or hypothyroidism

Biological therapies

Miscellaneous

Guide to further reading

Chapter 38 Hypothalamic, pituitary and sex hormones

Fertility regulation

Menstrual disorders

Guide to further reading

Chapter 39 Vitamins, calcium, bone

Vitamin A: retinol

Vitamin B complex

Vitamin C: ascorbic acid

Vitamin D, calcium, parathyroid hormone, calcitonin, bisphosphonates, bone

Treatment of calcium and bone disorders

Vitamin E: tocopherol

Vitamin K

Guide to further reading

Index

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