Cleft Lip and Palate Epidemiology Aetiology and Treatment 1st Edition by S. Karger AG, P. T. Sharpe, M. T. Cobourne – Ebook PDF Instant Download/Delivery. 9783318021080 ,3318021083
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ISBN 10: 3318021083
ISBN 13: 9783318021080
Author: S. Karger AG, P. T. Sharpe, M. T. Cobourne
Cleft Lip and Palate Epidemiology Aetiology and Treatment 1st Edition Table of contents:
Part 1: Descriptive Epidemiology for Orofacial Clefts
Geographical Variation in Prevalence
Ethnic Origin, Migration and Population Admixture Studies
Relative Proportions of Different Cleft Types
Dysmorphological Severity of Cleft and Additional Malformations
Unilateral Clefts and Laterality
Sex Distribution
Associated Anomalies, Stillbirths and Termination of Pregnancy
Clefts and Associated Malformations
Updates in Global Epidemiology
Data Deficiencies
Contemporary Epidemiology
Part 2: Descriptive Epidemiology from Selected Parts of the World Which Do Not Have Registries
Sub-Saharan Africa
India
Saudi Arabia
Ascertainment
Part 3: Other Characteristics of OFC Epidemiology
Sub-Phenotypes
Microforms
Termination of Pregnancy and Stillbirths
Prevalence, Type of Cleft and Dysmorphological Severity of Phenotype
Correlation of Prevalence Rates with Latitude and Longitude
Food Fortification with Folic Acid and Multivitamins
Mortality due to Orofacial Clefts
Inadequate Access to Care
With Supportive Care Only
Quantifying the Morbidity due to OFC
Conclusions
Acknowledgments
References
Genetic and Environmental Factors in Human Cleft Lip and Palate
Abstract
Gene Identification
Redefining Isolated Cleft Lip and Palate
Environment
Final Remarks
Acknowledgments
References
The Mouse as a Developmental Model for Cleft Lip and Palate Research
Abstract
The Mouse as a Model for Cleft Lip and Cleft Palate Research
Biochemical and Genetic Tools
Mutants Generated by Gene Targeting
Ubiquitous Gene Alterations
Mutants Generated by Other Strategies
Tissue-Specific Gene Targeting
Transgenic Mice
Mouse Models Generated by Insertional and ENU-Induced Mutagenesis
Avoiding the Mouse Trap
Scarcity of Mouse Models for CL/CP and Differences between Humans and Mice
Others Caveats
Concluding Remarks
Acknowledgments
References
Hedgehog Signalling in Development of the Secondary Palate
Abstract
Shh Expression in the Developing Palate
Role of Shh Signalling during Development of the Secondary Palate
Patterning along the Oro-Nasal Axis
Patterning along the Anteroposterior Axis
Acknowledgments
References
Roles of BMP Signaling Pathway in Lip and Palate Development
Abstract
Epidemiology and Genetics of CLP and CP
Lip and Palate Development
BMP Signaling Pathway
BMP Signaling Pathway in Palate Development
Expression Patterns
Animal Models
BMP and Orofacial Clefts in Humans
Concluding Remarks
References
Development of the Lip and Palate: FGF Signalling
Abstract
Basic Mechanisms of FGF Signalling
Role of FGF Signalling in the Embryonic Development of the Lip and Palate
FGF Receptors
FGF Ligands
FGF Pathway Mutations and the Pathogenesis of Human CLP
Conclusions and Future Directions
References
Wnt Signaling in Lip and Palate Development
Abstract
Wnt Signaling: Canonical or Non-Canonical?
Mutations in WNT Signaling Components Are Associated with CLP in Humans
Wnt Signaling and Upper Lip Formation
Canonical Wnt Signaling in Lip Development
Non-Canonical Wnt Signaling in Lip Formation
Canonical Wnt Signaling and Palate Development
Non-Canonical Wnt Signaling in Palate Development
Acknowledgments
References
Treatment Outcome for Children Born with Cleft Lip and Palate
Abstract
Limitations of Outcome Studies
Existing Outcomes
Surgical Outcomes
Study Models
Lateral Cephalograms
Other Outcomes in Cleft Care
Eurocleft
UK Clinical Standards Advisory Study
Subsequent Changes in Cleft Lip and Palate Service Provision
Americleft Study
Future Direction for Outcome Studies
References
Surgical Correction of Cleft Lip and Palate
Abstract
Timing of Surgery
Adjuncts to Surgery
Pre-Surgical Orthopaedics
Naso-Alveolar Moulding
Lip Adhesion
Gingivo-Periosteoplasty
Cleft Lip Repair
Cleft Palate Repair
Correction of Velopharyngeal Incompetence
Primary Management of the Cleft Lip Nose
Correction of Facial Skeletal Deformity
Future Outlook
References
Orthodontic Treatment in the Management of Cleft Lip and Palate
Abstract
Presurgical Maxillary Orthopaedics
Early Orthodontics (5-8 Years Old)
Post-Alveolar Bone Graft Development and Orthodontics (8-12 Years Old)
Conventional Orthodontics (11-15 Years Old)
Orthognathic and Osteogenic Distraction Surgical Orthodontics
Late and Retreatment Adult Orthodontics
References
Alveolar Bone Grafting
Abstract
Bone Grafting in the Mixed Dentition
Terminology and Goals of Bone Grafting
Timing of Bone Graft
Pre- and Post-Grafting Orthodontics
Surgical Technique
Type of Donor Bone and Donor Site Morbidity
Outcome Evaluation
Factors Influencing the Success of Alveolar Bone Grafting
Canine Impaction
Management of Space in the Dental Arch
The Future
References
Speech and Language in the Patient with Cleft Palate
Abstract
Development of Speech and Language
Normal Speech
Potential Barriers to Speech Development for a Child Born with Cleft Palate
Anatomy
Hearing
Syndromes
Incidence of Speech Problems for a Child Born with Cleft Palate
Assessment of Speech in the Child with Cleft Palate
Characteristics of Cleft Palate Speech
Abnormal Nasal Resonance
Abnormal Nasal Airflow
Cleft Speech Characteristics
Anterior Cleft Speech Characteristics
Posterior Cleft Speech Characteristics
Non-Oral Cleft Speech Characteristics
Passive Cleft Speech Characteristics
Velopharyngeal Dysfunction
Management of Velopharyngeal Dysfunction
Instrumentation
Speech and Language Therapy Treatment
Working Relationships within the Multidisciplinary Team
Clinical Nurse Specialist
The Orthodontist
Palatal Lifts and Speech Bulbs
Conclusions
References
Future Directions: Molecular Approaches Provide Insights into Palatal Clefting and Repair
Abstract
Cleft Palate
Development of the Secondary Palate
Mouse Models Reveal Sequential Developmental Requirements
Genetic Rescue of Palatal Shelf Outgrowth Reveals Epithelial-Mesenchymal Networks
Reversal of Palatal Elevation Defects Uncovers Neural Requirements
Hierarchical Signalling Requirements during Palatal Fusion
Engineering Drug-Dependent Genetic Mutants
In vivo Rescue of Cleft Palate
References
Author Index
Subject Index
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