Chronic Coronary Artery Disease A Companion to Braunwald Heart Disease 1st Edition by James de Lemos, Torbjørn Omland ISBN 9780323508759 0323508758

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Product details:
ISBN 10: 0323508758
ISBN 13: 9780323508759
Author: James de Lemos, Torbjørn Omland

Featuring expert guidance from Drs. James de Lemos and Torbjørn Omland, as well as other globally known leaders in cardiology, Chronic Coronary Artery Disease covers every aspect of managing and treating patients suffering from chronic coronary syndromes. This brand-new companion to Braunwald’s Heart Disease was designed as a stand-alone reference for physicians treating patients who present with complex, unique challenges, offering the latest information on the use of imaging modalities in diagnosis and treatment, advances in interventional and surgical approaches to revascularization, new medications to improve symptoms and outcomes in chronic CAD, and much more.

Chronic Coronary Artery Disease A Companion to Braunwald Heart Disease 1st Edition Table of contents:

Section I. Introduction

1. Epidemiology of Chronic Coronary Artery Disease

Introduction

Definitions

Risk Factors for Coronary Artery Disease

Conclusions

2. The Global Perspective of Ischemic Heart Disease

Introduction

Conclusions

Section II. Pathogenesis

3. Genetics of Coronary Atherosclerosis

Introduction

Heritability of Coronary Artery Disease

Mendelian Causes of Coronary Artery Disease

Common, Complex Forms of Coronary Artery Disease

Genetic Testing for Coronary Artery Disease in the Clinical Setting

Conclusions

4. Basic Mechanisms of Atherosclerosis

Introduction

Initiation of Atherosclerosis

Atherosclerotic Inflammation and Immune Activation

Calcification

The Vulnerable Plaque

Summary and Conclusions

5. Coronary Microvascular Dysfunction

Introduction

Functional Anatomy of the Coronary Circulation

Regulation of Myocardial Blood Flow

Mechanisms of Coronary Microvascular Dysfunction

Clinical Classification of Coronary Microvascular Dysfunction

Concluding Remarks

6. Precipitants of Myocardial Ischemia

Introduction

Clinical Predisposition

Specific Environmental Factors

Specific Cardiovascular Conditions

Conclusions

Section III. Clinical Evaluation

7. History and Physical Examination

Introduction

History

Assessment and Classification of Angina

Physical Examination

Conclusions

8. Lipid Measurements

Introduction

Traditional Lipoprotein Measurements

Measurement of Advanced Lipoproteins

Novel Lipid Tests

Lipid Targets on Treatment

Summary and Guideline Recommendations

9. Standard and Novel Biomarkers

Introduction

Biomarkers of Myocardial Injury

Biomarkers of Vascular Function and Neurohumoral Activity

Biomarkers of Renal Function

Lipid Biomarkers

Inflammatory Biomarkers

Novel, Omics-Based Biomarkers

Conclusions

10. ECG and Standard Exercise Stress Testing

Introduction

Indications for Electrocardiographic Testing

Exercise Treadmill Testing

Technical Aspects of Stress Testing

Stress Testing in Patients with Coronary Artery Disease

Prognosis

Therapeutic Efficacy

Preoperative Evaluation for Noncardiac Surgery

Conclusions

11. Echocardiography

Introduction

Detection of Coronary Artery Disease

Assessment of Left Ventricular Dysfunction

Structural Complications Due to Coronary Artery Disease

Summary

12. Nuclear Imaging and PET

Fundamentals of Radionuclide Imaging

Comprehensive Evaluation of Coronary Artery Disease

Patient-Centered Applications of Radionuclide Imaging in Coronary Artery Disease

Management of CAD

Myocardial Ischemia and Viability Imaging to Guide Revascularization in Patients with Ischemic LV Dysfunction

Cost-Effectiveness of Radionuclide Imaging in the Management of Stable Ischemic Heart Disease

Managing Radiation Exposure from Radionuclide Imaging

Potential Opportunities for Targeted Molecular Imaging

Summary

13. CT and MRI

Introduction

Cardiac Computed Tomography

Magnetic Resonance Imaging

CT and MRI: Guidelines

Conclusions

14. Invasive Testing

Coronary Angiography

Coronary Flow Reserve

Fractional Flow Reserve

Intravascular Imaging

Index of Microcirculatory Resistance

Evaluation of Chest Pain and no Obstructive Coronary Artery Disease

Conclusion

15. Putting It All Together: Which Test for Which Patient?

The Challenge of Noninvasive Test Selection for Stable Chest Pain

Overview: Patient Selection for Noninvasive Testing

General Approach to Choosing a Noninvasive Test

A New Standard for Pragmatic Imaging Trials: Promise and Scot-Heart

Important Downstream Sequelae of Noninvasive Testing

Noninvasive Diagnostic Testing Considerations for Special Populations

Emerging Concepts: Beyond the Siloed Choice of a Functional or Anatomic Strategy

Future Horizons for Noninvasive Imaging and CAD

A Proposed Approach for Selecting the Optimal Noninvasive Test for CAD Diagnosis

Summary

Section IV. Management

16. Goals of Therapy

Improving Survival and Prevention of Major Adverse Cardiac Events

Improving Symptoms and Quality of Life

Special Populations

Conclusions: Developing an Individualized Plan of Care

17. Global Risk Assessment

Introduction

Prognosis Overall and in Subgroups

Prognosis in Subgroups

Tools for Risk Assessment

Multivariable Risk Prediction Models in Chronic Coronary Artery Disease

Summary

18. Lifestyle Interventions

Smoking

Nutrition

Physical Activity

Cardiac Rehabilitation

Uptake and Adherence to Lifestyle Changes and Cardiac Rehabilitation

19. Obesity and the Obesity Paradox

Introduction

Mechanisms Linking Obesity with Increased CHD Risk

Association of Obesity with CVD Events

Impact of Obesity on Prognosis in CHD: The Obesity Paradox

Challenges with BMI as a Measure of Adiposity

Potential Reasons for an Obesity Paradox in CHD

Impact of Weight Loss on CHD

Prevention of Obesity and Weight Gain

Pharmacologic Treatment of Obesity

Bariatric Surgery

Conclusion

20. The Medical Treatment of Stable Angina

Introduction

Traditional Anti-Ischemic Therapy

Novel Anti-Ischemic Therapy

Investigational Anti-Ischemic Therapy

Comparative Effectiveness of Drug Classes Singly and in Combination in the Treatment of Stable Angina

Guidelines for the Medical Management of Stable Angina

Conclusion

21. Antiplatelet and Anticoagulant Drugs

Introduction

Antiplatelet Agents

Anticoagulants

Future Perspectives

Conclusions

22. Prevention of Sudden Cardiac Death

Introduction

Definition and Epidemiology

Pathophysiology

Secondary Prevention of Sudden Cardiac Death

Primary Prevention of Sudden Cardiac Death

Summary of Recommendations for Implantable Cardioverter Defibrillator Implantation for Prevention of Sudden Cardiac Death

Conclusions

23. Revascularization Approaches

Introduction

Goals of Treatment

Conclusions

24. Managing Chronic Coronary Artery Disease in Patients with Diabetes

Introduction

Cardiovascular Risk in Type 1 Diabetes

Cardiovascular Risk in Type 2 Diabetes Mellitus

Risk Factor Management

Coronary Revascularization in Patients with Cad and Diabetes

Optimal Medical Treatment Versus Coronary Revascularization

Specific Characteristics of Revascularization Therapy in Patients with Insulin-Dependent and Patients with Non–Insulin-Dependent Diabetes

Clinical Decision-Making in Patients with Multivessel Disease with Diabetes

25. Angina in Patients with Evidence of Myocardial Ischemia and No Obstructive Coronary Artery Disease

Introduction

Terminology

Epidemiology

Pathophysiology

Diagnostic Testing

Therapeutic Strategies

Conclusions

26. Depression, Anxiety, and Stress

Introduction

Professional Society Guidelines/Advisories/Statements

Epidemiology

Biologic Mechanisms

Behavioral Mechanisms

Treatment Options

Should Professional Society Guidelines/Advisories/Statements be Followed?

Practical Considerations for Treating Comorbid Coronary Heart Disease and Depression, Anxiety, or Stress

27. Refractory Angina

Introduction

Drug Therapy

Interventional Therapies

Mental Stress–Induced Myocardial Ischemia

Refractory Vasospastic Angina

Refractory Angina in Patients with Coronary Microvascular Dysfunction

Noninvasive Therapies

How to Approach Patients with Refractory Angina

Section V. Prevention

28. Primary Prevention of Atherosclerotic Cardiovascular Disease

Encourage Long-Term Adherence

Overview of Primary Prevention Priorities by Age Group

Lifestyle Recommendations

Cholesterol Management

Blood Pressure

Aspirin

Conclusions

29. Screening for Atherosclerotic Cardiovascular Disease in Asymptomatic Individuals

Introduction

Concluding Thoughts on Screening the Asymptomatic Individual

30. Secondary Prevention of Coronary Artery Disease

Introduction

Risk Factor Management

Optimal Pharmacologic Therapy

Additional Preventive Strategies

Conclusions

Index

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