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Chiral Separations Methods and Protocols 1st Edition by Gerald GÃ¼bitz, Martin Schmid 8184894864 978-8184894868

Name: Chiral Separations Methods and Protocols 1st Edition by Gerald GÃ¼bitz, Martin Schmid 8184894864 978-8184894868
SKU: EB-9978
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Authors:Gerald Gubitz , Series:Microbiology [11] , Tags:Microbiology , Author sort:Gubitz, Gerald , Identifiers:Identifiers:isbn-13:978-1588291509 , Languages:Languages:eng , Published:Published:Mar 2004 , Publisher:Humana Press , Comments:Comments:Many compounds of biological and pharmacological interest are as- metric and show optical activity. Approximately 40% of the drugs in use are known to be chiral and only about 25% are administered as pure enantiomers. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers (eutomer). In several cases, unwanted side effects or even toxic effects may occur with the inactive enantiomer (distomer). Even if the side effects are not that drastic, the inactive enantiomer has to be meta- lized, which represents an unnecessary burden for the organism. The admin- tration of pure, pharmacologically active enantiomers is therefore of great importance. The ideal way to get to pure enantiomers would be by enantioselective synthesis. However, this approach is usually expensive and not often practicable. Usually, the racemates are obtained in a synthesis, and the separation of the enantiomers on a preparative scale is necessary. On the other hand, there is also a great demand for methods of enantiomer separation on an analytical scale for controlling synthesis, checking for racemization p- cesses, controlling enantiomeric purity, and for pharmacokinetic studies. C- ventional methods for enantiomer separation on a preparative scale are fractionated crystallization, the formation of diastereomeric pairs followed by repeated recrystallization, and enzymatic procedures. In recent years, ch- matographic methods such as gas chromatography and, especially, liquid ch- matography have attracted increasing interest for chiral separation, both on analytical and preparative scales.

SKU: EB-9978 Category: eBook PDF Tags: Chiral, Gerald GÃ¼bitz, Martin Schmid, Separations

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ISBN 10: 8184894864

ISBN 13: 978-8184894868

Author: Gerald Gübitz, Martin G. Schmid

Methods for enantiomer separation are very important for controlling synthesis, for checking racemization, for enantiomeric purity control, and for pharmacokinetic studies. In Chiral Separations: Methods and Protocols, prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotogrphic, gas chromatographic, and supercritical fluid chromatographic as well as recent electrochromotographic techniques. Each fully tested protocol includes an introduction to the principle underlying the method, equipment and reagent lists, and helpful notes on troubleshooting and avoiding known pitfalls.
Up-to-date and highly practical, Chiral Separations: Methods and Protocols will help both novice and advanced users not only choose optimal methods for their separation problems, but also readily obtain successful results.

Chiral Separations Methods and Protocols 1st Table of contents:

Chiral Separation Principles
Separation of Enantiomers by Thin-Layer Chromatography
Cyclodextrin-Based Chiral Stationary Phases for Liquid Chromatography
Enantiomeric Separations by HPLC Using Macrocyclic Glycopeptide-Based Chiral Stationary Phases
Chiral Separation by HPLC Using Polysaccharide-Based Chiral Stationary Phases
Applications of Polysaccharide-Based Chiral Stationary Phases for Resolution of Different Compound Classes
Chiral Separation by HPLC With Pirkle-Type Chiral Stationary Phases
Chiral Separation by HPLC Using the Ligand-Exchange Principle
Chiral Separations by HPLC Using Molecularly Imprinted Polymers
Indirect Enantioseparation by HPLC Using Chiral Benzofurazan-Bearing Reagents
Separation of Racemic Trans-Stilbene Oxide by Sub-/Supercritical Fluid Chromatography
Chiral Separations Using the Macrocyclic Antibiotics in Capillary Electrophoresis
Enantioresolutions by Capillary Electrophoresis Using Glycopeptide Antibiotics
Separation of Enantiomers by Capillary Electrophoresis Using Cyclodextrins
Chiral Separations by Capillary Electrophoresis Using Proteins as Chiral Selectors
Cellulases as Chiral Selectors in Capillary Electrophoresis
Use of Chiral Crown Ethers in Capillary Electrophoresis
Chiral Separations by Capillary Electrophoresis Using Cinchona Alkaloid Derivatives as Chiral Counter-Ions
Chiral Separation by Capillary Electrophoresis Using Polysaccharides
Chiral Micellar Electrokinetic Chromatography
Chiral Separation by Capillary Electrophoresis in Nonaqueous Medium
Chiral Ligand-Exchange Capillary Electrophoresis and Capillary Electrochromatography
Enantioseparation in Capillary Chromatography and Capillary Electrochromatography Using Polysaccharide-Type Chiral Stationary Phases
Chiral Separation by Capillary Electrochromatography Using Cyclodextrin Phases
Chiral Separations by Capillary Electrochromatography Using Molecularly Imprinted Polymers

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