Cellular and Molecular Basis of Mitochondrial Inheritance Mitochondrial Disease and Fitness 1st Edition by Peter Sutovsky 9783030045708 3030045706

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ISBN-10 :  9783030045708

ISBN-13 ‏ : ‎ 3030045706

Author: Peter Sutovsky

This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.

Cellular & Molecular Basis of Mitochondrial Inheritance Mitochondrial Disease & Fitness 1st Table of contents:

• Autophagosomal Sperm Organelle Clearance and mtDNA Inheritance in C. elegans

  • Explores the mechanisms by which sperm organelles are cleared via autophagy in Caenorhabditis elegans, influencing mitochondrial DNA inheritance.

• Doubly Uniparental Inheritance of mtDNA: A Model for Understanding the Role of Mitochondria in Fitness Differences Between the Sexes

  • Examines the phenomenon of doubly uniparental inheritance (DUI) of mitochondrial DNA and its impact on fitness variations between male and female organisms.

• Mitochondrial Inheritance in Mammals

  • Provides an overview of mitochondrial inheritance patterns in mammalian species, highlighting maternal inheritance and associated genetic implications.

• Mitochondrial DNA in Human Reproduction

  • Discusses the role of mitochondrial DNA in human reproductive processes, including its influence on fertility and embryonic development.

• Mitochondrial Replacement Therapy: The Transplantation of Pronuclei, Spindles, and Polar Bodies for the Prevention of mtDNA Disease

  • Reviews advanced reproductive techniques aimed at preventing mitochondrial DNA diseases through the transplantation of nuclear and cytoplasmic components.

• Mitochondrial DNA in Aging and Disease

  • Analyzes the relationship between mitochondrial DNA mutations, the aging process, and the development of various diseases.

• Mitochondrial Dynamics and Quality Control

  • Explores the processes of mitochondrial fusion, fission, and autophagy (mitophagy) in maintaining mitochondrial function and cellular health.

• Environmental and Nutritional Modulation of Mitochondrial Function

  • Investigates how environmental factors and nutrition influence mitochondrial function and overall organismal fitness.

• Mitochondrial Fitness and Evolution

  • Examines the role of mitochondria in evolutionary biology, focusing on how mitochondrial efficiency and adaptability affect species evolution.

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