Cell Differentiation of Neoplastic Cells Originating in the Oral and Craniofacial Regions 1st Edition by Toshiyuki Kawakami Hitoshi Nagatsuja ISBN 1604569328 978-1604569322

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ISBN 10:  1604569328 
ISBN 13: 978-1604569322
Author: Toshiyuki Kawakami, Hitoshi Nagatsuja 

Development of the oral and craniofacial region is a complex and fascinating set of processes which require a sequential integration of numerous biological steps. For medical and dental doctors, interest is particularly high in this region, because it is composed of three blastoderms – ectoderm, mesoderm and endoderm – as well as neural crest cells. There are many different types of neoplasms in this region. In general, proliferation, development and cytological differentiation of the neoplastic cells reflect the normal physiological development of the outbreak mother cells and/or tissues. Collected human neoplasm cases, such as osteosarcoma appearing in the oral and craniofacial region, are examined regarding the immunohistochemical expression of some morphogenesis regulation factors. Furthermore, examination of Notch signalling is also conducted for some odontogenic neoplasms.This book mainly describes the examination results of some morphogenesis regulation factors, such as Notch signalling, in the neoplastic cells originating in the oral and craniofacial region, especially in the odontogenic neoplasms, in both well-differentiated and poorly-differentiated neoplasms of tooth germ enamel organ-derived neoplasm. In general, these morphogenesis regulation factors are responsible for cytological regulation of cell fate, morphogenesis and/or development. The results suggest that these factors play some role in cytological differentiation or acquisition of tissue specific characteristics in neoplastic cells. Furthermore, there would appear to be a relationship between the cytological differentiation in the oral and craniofacial neoplastic cells and the physiological development and differentiation of their originating mother cells and tissues of the oral and craniofacial region.

Cell Differentiation of Neoplastic Cells Originating in the Oral and Craniofacial Regions 1st Table of contents:

Biology of neoplasms 

 Developmental biology of teeth

Developmental oral craniofacial biology

Mandibular bone and cartilage development

Notch signaling in cell differentiation and development

Cell differentiation in pathological conditions

Odontogenic neoplasms

Notch signaling in ameloblastomas and ameloblastic carcinomas

Cell differentiation in odontogenic neoplasms

Cell differentiation in neoplasms of bone and cartilage

Cell differentiation in BMP-induced heterotopic osteogenesis conclusion.

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