Cecil Essentials of Medicine 10th Edition by Edward Wing,Fred Schiffman 9780323722735 0323722733

SECTION I. Introduction to Medicine

1. Introduction to Medicine

SECTION II. Cardiovascular Disease

2. Structure and Function of the Normal Heart and Blood Vessels

Definition

Circulatory Pathway

Conduction System

Neural Innervation

Myocardial Structure

Muscle Physiology and Contraction

3. Evaluation of the Patient With Cardiovascular Disease

Definition and Epidemiology

Pathology

Clinical Presentation

Diagnosis and Physical Examination

4. Diagnostic Tests and Procedures in the Patient With Cardiovascular Disease

Electrocardiography

Abnormal Electrocardiographic Patterns

Ambulatory Electrocardiographic Recording

Chest Radiography

Echocardiography

Nuclear Cardiology

Cardiac Magnetic Resonance Imaging

Stress Testing

Stress Imaging

Computed Tomography of the Heart

Cardiac Catheterization

Endomyocardial Biopsy

Noninvasive Vascular Testing

5. Heart Failure and Cardiomyopathy

Definition and Classification

Pathophysiology

Diagnosis and Management Of Acute Decompensation

Future Directions

6. Congenital Heart Disease

Introduction

Acyanotic Heart Disease

Cyanotic Heart Disease

7. Valvular Heart Disease

Introduction

Aortic Stenosis

Mitral Stenosis

Pulmonic Stenosis

Tricuspid Stenosis

Aortic Regurgitation

Mitral Regurgitation

Pulmonic Regurgitation

Tricuspid Regurgitation

8. Coronary Heart Disease

Definition and Epidemiology

Risk Factors for Atherosclerosis

Pathology

Clinical Presentations of Coronary Artery Disease

Prognosis

9. Cardiac Arrhythmias

Basic Cellular Electrophysiology

General Approach to Management

Bradycardia

Tachycardias

Syncope

Ventricular Arrhythmias and Sudden Cardiac Death

Summary

10. Pericardial and Myocardial Disease

Pericardial Disease

Diseases of the Myocardium

11. Other Cardiac Topics

Cardiac Disease in Pregnancy

Cardiac Tumors

Traumatic Heart Disease

Percutaneous Mechanical Circulatory Support

Noncardaic Surgery in the Patient With Cardiovascular Disease

12. Vascular Diseases and Hypertension

Introduction

Systemic Vascular Disease

Pulmonary Vascular Disease

Venous Thromboembolic Disease

Arterial Hypertension

Treatment of Hypertension

Prognosis

Prospects for the Future

SECTION III. Pulmonary and Critical Care Medicine

13. Lung in Health and Disease

Introduction

Lung Development

Pulmonary Disease

Prospectus for the Future

14. General Approach to Patients With Respiratory Disorders

Introduction

Clinical Presentation

History

Physical Examination

Evaluation

Prospectus for the Future

15. Evaluating Lung Structure and Function

Introduction

Anatomy

Physiology

Evaluation of Lung Function

Evaluation of Lung Disease

Prospectus for the Future

16. Obstructive Lung Diseases

Introduction

Chronic Obstructive Pulmonary Disease

Bronchiolar Disorders

Bronchiectasis

Cystic Fibrosis

Asthma

17. Interstitial Lung Diseases

Overview

Idiopathic Interstitial Lung Diseases

Exposure-Related Ilds

ILD Due to Systemic Diseases

Summary

18. Pulmonary Vascular Diseases

Introduction

Pulmonary Hypertension

Other Types of Pulmonary Hypertension

Pulmonary Thromboembolism

Prospectus for the Future

19. Disorders of the Pleura, Mediastinum, and Chest Wall

Pleural Disease

Mediastinal Disease

Chest Wall Disease

Prospectus for the Future

20. Respiratory Failure

Introduction

Pathophysiology

Classification of Respiratory Failure

Specific Clinical Situation: Acute Respiratory Distress Syndrome

21. Transitions in Care From Pediatric to Adult Providers for Individuals With Pulmonary Disease

Introduction

Cystic Fibrosis and Other Mucociliary Diseases

Asthma and Bronchopulmonary Dysplasia

Diffuse Lung Disease (Interstitial Lung Disease)

Individuals with Technology Dependence or Other Special Health Care Needs

Importance of a Successful Transition

SECTION IV. Preoperative and Postoperative Care

22. Preoperative and Postoperative Care

Introduction

Cardiac Disease

Identification of Patients with Elevated Risk

Preoperative Cardiac Risk Assessment

Preoperative Risk Modification to Reduce Perioperative Cardiac Risk

Postoperative Cardiac Risk Assessment

Noncardiac Surgery in Patients with Specific Cardiovascular Conditions

Renal Disease

Hepatic Disease

Pulmonary Disease

Endocrine Disease

Hematologic Disease

Infectious Disease

Neurologic Disease

Rheumatologic Disease

Special Needs of the Geriatric Patient

Summary

SECTION V. Renal Disease

23. Renal Structure and Function

Introduction

Renal Structure

Renal Function

24. Approach to the Patient With Renal Disease

Introduction

Approach to the Patient with Chronic Kidney Disease

Approach To The Patient With Acute Kidney Injury

25. Fluid and Electrolyte Disorders

Normal Volume Homeostasis

Hyponatremia

Hypernatremia

Hypokalemia

Hyperkalemia

Metabolic Acidosis

Metabolic Alkalosis

Respiratory Alkalosis

Respiratory Acidosis

26. Glomerular Diseases

Introduction

Clinical Presentation

Clinical Syndromes

Primary Podocytopathies

Immune-Complex Glomerulonephritis

Glomerular Diseases Caused By Plasma Cell Dyscrasias

Fibrillary Glomerulonephritis and Immunotactoid Glomerulopathy

Glomerulonephritis Associated with Viral Infections

Thrombotic Microangiopathies

Diseases with Glomerular Basement Membrane Abnormalities

Fabry’s Disease

Diabetic Nephropathy

27. Major Nonglomerular Disorders of the Kidney

Introduction

Acute Interstitial Nephritis

Chronic Interstitial Nephritis

Cystic Kidney Diseases

Tuberous Sclerosis

Von Hippel–Lindau Disease

Kidney Tumors

Nephrolithiasis

28. Vascular Disorders of the Kidney

Introduction

Renal Vascular Anatomy

Renovascular Disease

Thrombotic Microangiopathy of the Kidney

Antiphospholipid Antibody Syndrome

Renal Vein Thrombosis

29. Acute Kidney Injury

Definition

Etiology

Epidemiology

Diagnostic Evaluation

Clinical Presentation, Differential Diagnosis, and Management of AKI

Complications of AKI

General Management of AKI

Outcome and Prognosis of AKI

30. Chronic Kidney Disease

Definition and Epidemiology

Pathology

Clinical Presentation

Diagnosis

Treatment

Prognosis

SECTION VI. Gastrointestinal Disease

31. Common Clinical Manifestations of Gastrointestinal Disease: Abdominal Pain

Definition and Epidemiology

Physiology

Causes of Abdominal Pain

Clinical Presentation

Acute Abdomen

Chronic Abdominal Pain

32. Common Clinical Manifestations of Gastrointestinal Disease: Gastrointestinal Hemorrhage

Introduction

Approach to PatientS with Gastrointestinal Bleeding

33. Common Clinical Manifestations of Gastrointestinal Disease: Malabsorption

Definition and Epidemiology

Digestion and Absorption of Fat

Digestion and Absorption of Carbohydrates

Digestion and Absorption of Proteins

Mechanisms of Malabsorption

Clinical Presentation

Diagnosis

Treatment

Malabsorptive Therapy

34. Common Clinical Manifestations of Gastrointestinal Disease: Diarrhea

Definition

Pathophysiology

Evaluation of Acute Diarrhea

Chronic Diarrhea

35. Endoscopic and Imaging Procedures

Introduction

Gastrointestinal Endoscopy

Nonendoscopic Imaging Procedures

Prospectus for the Future

36. Esophageal Disorders

Introduction

Symptoms of Esophageal Disease

Diagnostic Studies of the Esophagus

Structural Disorders

Gastroesophageal Reflux Disease and Sequelae

Motility Disorders

Variant Forms of Esophagitis

Esophageal Infections

Esophageal Trauma and Emergencies

Systemic and Other Illnesses

37. Diseases of the Stomach and Duodenum

Introduction

Anatomy

Histology

Histology of the Duodenum

Gastroduodenal Secretions

Gastroduodenal Motility

Peptic Ulcer Disease

Zollinger-Ellison Syndrome

Gastritis

Functional (Nonulcer) Dyspepsia

Cyclic Vomiting Syndrome

Rapid Gastric Emptying

Gastroparesis

Gastric Volvulus

38. Inflammatory Bowel Disease

Introduction

Epidemiology

Risk Factors and Pathophysiology

Clinical Presentation

Diagnosis and Differential Diagnosis

Treatment

Prognosis

39. Diseases of the Pancreas

Acute Pancreatitis

Chronic Pancreatitis

Carcinoma of the Pancreas

SECTION VII. Diseases of the Liver and Biliary System

40. Laboratory Tests in Liver Diseases

Introduction

Liver Chemistry Tests

Liver Synthetic Function

41. Jaundice

Introduction

Bilirubin Metabolism

Laboratory Measurement of Bilirubin

Unconjugated Hyperbilirubinemia

Neonatal Jaundice

Conjugated Hyperbilirubinemia

Clinical Approach to the Evaluation of Jaundice

42. Acute and Chronic Hepatitis

Introduction

Acute Hepatitis

Chronic Hepatitis

43. Acute Liver Failure

Definitions

Pathogenesis

Clinical Presentation

Diagnosis

Treatment

Prognosis

44. Cirrhosis of the Liver and Its Complications

Liver Cirrhosis

Complications of Cirrhosis

Variceal Hemorrhage

Ascites

Spontaneous Bacterial Peritonitis

Hepatorenal Syndrome

Hepatic Encephalopathy

Hepatopulmonary Syndrome and Portopulmonary Hypertension

Hepatocellular Carcinoma

Vascular Disease of the Liver

Liver Transplantation

45. Disorders of the Gallbladder and Biliary Tract

Introduction

Normal Biliary Anatomy and Physiology

Gallbladder Disorders

Biliary Tract Disorders

SECTION VIII. Hematologic Disease

46. Hematopoiesis and Hematopoietic Failure

Hematopoiesis

Primary Hematopoietic Failure Syndromes

Prospectus for the Future

47. Clonal Disorders of the Hematopoietic Stem Cell

Introduction

Myeloproliferative Neoplasms

Polycythemia Vera

Essential Thrombocythemia

Primary (Idiopathic) Myelofibrosis

Chronic Myelogenous Leukemia

Acute Leukemias

Prospectus for the Future

48. Disorders of Red Blood Cells

Normal Red Blood Cell Structure and Function

Clinical Presentation

Laboratory Evaluation

Evaluation of Hypoproliferative Anemias

Evaluation of Anemia With Reticulocytosis

Prospectus for the Future

49. Clinical Disorders of Granulocytes and Monocytes

Introduction

Normal Granulocyte Development, Structure, and Function

Determinants of Peripheral Neutrophil Numbers

Neutrophilia

Neutropenia

Prospectus for the Future

50. Disorders of Lymphocytes

Introduction

Lymphocyte Development, Function, and Localization

Neoplasia of Lymphoid Origin

Congenital and Acquired Disorders of Lymphocyte Function

51. Normal Hemostasis

Introduction

Vasculature Physiology

Von Willebrand Factor

Platelet Physiology

Coagulation

52. Disorders of Hemostasis: Bleeding

Introduction

Hemostasis

Clinical Evaluation of Bleeding

Laboratory Evaluation of Bleeding

Bleeding Caused by Vascular Disorders

Bleeding Caused by Thrombocytopenia

Bleeding Caused by Platelet Function Defects

Bleeding Caused by Von Willebrand Disease

Bleeding Caused by Coagulation Factor Disorders

Bleeding in Patients with Normal Laboratory Values

Prospectus for the Future

53. Disorders of Hemostasis: Thrombosis

Pathology Of Thrombosis

Clinical Evaluation Of Thrombosis

Therapy For Venous Thromboembolism

SECTION IX. Oncologic Disease

54. Cancer Biology

Introduction

The Genetics of Cancer

The Tumor Microenviroment

Hallmarks of Cancer

55. Cancer Epidemiology

Introduction

Cancer Epidemiology Methods

Risk Factors

Cancer Prevention

Cancer Screening

56. Principles of Cancer Therapy

Introduction

Diagnosis and Staging

Principles of Cancer Surgery

Principles of Radiation Therapy

Principles of Medical Therapy

Evaluation of Response

Supportive Care

57. Lung Cancer

Definition and Epidemiology

Pathology

Clinical Presentation

Diagnosis and Differential Diagnosis

Treatment

Prognosis

58. Gastrointestinal Cancers

Introduction

Esophageal Cancer

Gastric Cancer

Pancreatic Cancer

Cholangiocarcinoma (Bile Duct Cancers)

Hepatocellular Carcinoma

Colorectal Cancer

Anal Cancer

59. Genitourinary Cancers

Renal Cell Carcinoma

Bladder Cancer

Prostate Cancer

Testicular Cancer

60. Breast Cancer

Epidemiology

Risk Factors