Cardiovascular Calcification and Bone Mineralization 1st Edition by Elena Aikawa, Joshua D Hutcheson ISBN 9783030467258

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ISBN 10: 
ISBN 13: 9783030467258
Author: Elena Aikawa, Joshua D Hutcheson

The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed.

Cardiovascular Calcification and Bone Mineralization 1st Table of contents:

Chapter 1: Introduction to Cardiovascular Calcification

• Overview of Cardiovascular Calcification
• Types of Cardiovascular Calcification (Intimal vs. Medial)
• Role of Calcification in Cardiovascular Disease
• Mechanisms of Vascular Calcification

Chapter 2: Bone Mineralization and Its Role in Health

• Basics of Bone Mineralization
• Osteogenesis and Bone Formation
• The Bone-Mineralization Balance and Its Importance
• Osteoblasts, Osteoclasts, and Osteocytes in Bone Health

Chapter 3: The Link Between Cardiovascular Calcification and Bone Health

• Shared Pathophysiological Mechanisms Between the Heart and Bone
• Role of Osteoprotegerin, RANK/RANKL Pathway, and Other Signaling Molecules
• The Bone-Vascular Axis: Mechanisms and Implications
• Vitamin K, D, and Calcium in Both Bone and Cardiovascular Health

Chapter 4: Pathophysiology of Vascular Calcification

• Vascular Smooth Muscle Cells and Calcification
• The Role of Inflammation in Vascular Calcification
• Risk Factors for Cardiovascular Calcification (Age, Diabetes, Hypertension, etc.)
• Genetic Factors in Cardiovascular Calcification

Chapter 5: Imaging and Assessment of Cardiovascular Calcification

• Techniques for Imaging Vascular Calcification (CT, MRI, Ultrasound)
• Scoring Systems and Measurement of Calcification (Agatston Score, etc.)
• The Role of Imaging in Risk Stratification and Disease Monitoring
• Quantification of Bone Mineral Density

Chapter 6: Cardiovascular Calcification in Atherosclerosis

• Calcification in Coronary Artery Disease (CAD)
• Calcified Plaques: Clinical Implications and Outcomes
• Calcification and Vulnerable Plaques
• Interventions and Their Impact on Coronary Calcification

Chapter 7: Cardiovascular Calcification and Renal Disease

• The Relationship Between Chronic Kidney Disease (CKD) and Vascular Calcification
• Role of Phosphate, Calcium, and Parathyroid Hormone in CKD-related Calcification
• Mechanisms and Risk Factors for Calcification in Renal Patients
• Management Strategies for Vascular Calcification in CKD

Chapter 8: Bone Mineralization and Cardiovascular Risk

• Osteoporosis and Cardiovascular Disease: A Bidirectional Relationship
• The Role of Bone Mineral Density in Cardiovascular Disease Risk
• Osteoporosis Medications and Their Impact on Cardiovascular Health
• Managing Bone and Cardiovascular Health Simultaneously

Chapter 9: Therapeutic Approaches to Cardiovascular Calcification

• Pharmacological Treatments to Inhibit Vascular Calcification
• Role of Bisphosphonates, Statins, and Vitamin D in Calcification Prevention
• Novel Targeted Therapies (Calcification Inhibitors, Matrix Gla-Protein, etc.)
• Interventional and Surgical Approaches to Treat Calcified Lesions

Chapter 10: Therapeutic Approaches to Bone Mineralization

• Current Pharmacologic Interventions for Osteoporosis and Bone Health
• The Role of Calcium, Vitamin D, and Other Supplements
• Advances in Bone-Targeted Therapies
• Lifestyle Interventions for Improving Bone Health

Chapter 11: The Role of Inflammation in Cardiovascular and Bone Calcification

• Inflammatory Pathways in Cardiovascular Calcification
• The Role of Cytokines and Immune Cells in Vascular Calcification
• Inflammatory Mediators and Their Impact on Bone Health
• Therapeutic Targets in Inflammation for Dual Bone and Vascular Protection

Chapter 12: Emerging Research and Future Directions

• Novel Insights into the Molecular Mechanisms of Vascular Calcification
• The Role of Stem Cells and Regenerative Medicine in Vascular and Bone Health
• Advancements in Imaging Technologies for Calcification Detection
• Future Drug Development for Combined Bone and Vascular Health

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