Cardio Oncology Management of Toxicities in the Era of Immunotherapy 1st edition by Antonio Russo, Nicola Maurea, Dimitrios Farmakis, Antonio Giordano ISBN 3030977463 978-3030977467

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ISBN 10: 3030977463
ISBN 13:  978-3030977467
Author: Antonio Russo, Nicola Maurea, Dimitrios Farmakis, Antonio Giordano

The development of immunotherapy in oncology field has revolutionized the prognosis of many types of cancer. The immune checkpoint inhibitors target receptors whose inhibition increases the activity of immune system cells against tumor cells. In recent years, new immunotherapies have been studied and approved in a growing number of tumors including melanoma, non-small cell lung cancer (NSCLC), and renal cell cancer (RCC). This volume provides a complete and updated state-of-art review regarding the management of cardiovascular toxicities from new immunotherapies. The manuscript is divided into different sections starting from the relationship between cancer and immune system to let the reader understand the new molecular concepts under immunotherapy development. Subsequent chapters describe specifically the immunotherapy options in solid tumor treatment and the main features of the immuno-related cardiovascular complications. This volume is written by experts in the oncological and cardiovascular fields and aims to provide to clinicians who approach current cancer patients a useful tool to move through the paths of modern cardio-oncology. An important section would afford the most relevant interventions needed to manage the cardiac events, suggesting how to reduce their impact and effects on oncological outcomes. The text concludes by addressing future perspectives in the cardio-immunology field, discussing many aspects such as the early detection of cardiovascular damage and the potential role of liquid biopsy in new damage-related biomarkers discovery.

Cardio-Oncology Management of Toxicities in the Era of Immunotherapy 1st Table of contents:

Preface

• Introduction to Cardio-Oncology
• The Intersection of Cancer Therapy and Cardiac Health
• Overview of Immunotherapy and Its Impact on Cardiotoxicity
• How to Use This Book

Chapter 1: Introduction to Cardio-Oncology

• Defining Cardio-Oncology: A Multidisciplinary Approach
• The Rise of Immunotherapy in Cancer Treatment
• Cardiac Toxicity in Cancer Treatment: Challenges and Opportunities
• The Importance of Monitoring Cardiac Health During Cancer Therapy

Chapter 2: Overview of Immunotherapy in Oncology

• Principles of Immunotherapy and Its Mechanisms of Action
• Types of Immunotherapies: Monoclonal Antibodies, Checkpoint Inhibitors, and CAR-T Cell Therapy
• Benefits and Risks of Immunotherapy for Cancer Treatment
• Current Landscape of Immunotherapy in Various Cancer Types

Chapter 3: Understanding Cardiotoxicity in Cancer Treatments

• Types of Cardiotoxicity in Cancer Treatment: Acute vs. Chronic
• Mechanisms of Cardiotoxicity: From Chemotherapy to Targeted Therapy and Immunotherapy
• Risk Factors for Cardiotoxicity in Cancer Patients
• Identifying High-Risk Patients for Cardiotoxicity

Chapter 4: Immunotherapy and Cardiotoxicity

• The Impact of Immune Checkpoint Inhibitors on Cardiac Function
• Myocarditis and Other Cardiac Adverse Events from Immunotherapy
• Mechanisms Behind Immunotherapy-Induced Cardiotoxicity
• Immunotherapy-Induced Cardiovascular Disease: An Overview of Recent Studies

Chapter 5: Diagnosis of Cardiotoxicity in Cancer Patients

• Clinical Signs and Symptoms of Cardiotoxicity
• Diagnostic Tools: ECG, Echocardiography, and Biomarkers
• Role of Cardiac Imaging in Monitoring Immunotherapy-Induced Toxicity
• The Importance of Early Detection: Screening for Cardiotoxicity in Cancer Patients

Chapter 6: Management of Cardiotoxicity in Cancer Patients

• General Principles of Managing Cardiotoxicity
• Pharmacological Management: Use of Beta-Blockers, ACE Inhibitors, and Diuretics
• Immunosuppressive Therapy for Immune-Mediated Cardiotoxicity
• The Role of Anticancer Treatments: Adjusting Therapy for Cardiac Health
• Strategies for Preventing and Minimizing Cardiac Toxicity

Chapter 7: Managing Myocarditis Induced by Immunotherapy

• Diagnosis and Clinical Presentation of Myocarditis in Cancer Patients
• Pathophysiology and Mechanisms of Immunotherapy-Induced Myocarditis
• Treatment Protocols for Myocarditis: Corticosteroids and Other Immunosuppressive Therapies
• Prognosis and Long-Term Follow-Up for Myocarditis Patients

Chapter 8: Other Cardiovascular Toxicities in the Era of Immunotherapy

• Hypertension and Arrhythmias in Cancer Patients on Immunotherapy
• Coronary Artery Disease, Heart Failure, and Other Cardiovascular Complications
• Impact of Immunotherapy on the Microvascular System and Endothelial Function
• Long-Term Cardiovascular Risks Post-Immunotherapy

Chapter 9: Multidisciplinary Approaches to Cardio-Oncology Care

• Collaborative Care Between Cardiologists, Oncologists, and Primary Care Providers
• Communication Strategies for Effective Multidisciplinary Teams
• Developing Comprehensive Treatment Plans for Patients at Risk of Cardiotoxicity
• The Role of Cardio-Oncology Clinics and Specialized Care

Chapter 10: Personalized Management of Cardiotoxicity

• Assessing Individual Risk Factors for Cardiotoxicity in Cancer Patients
• Personalized Approaches to Cardiac Monitoring and Intervention
• Tailoring Treatment Strategies Based on Genetic and Molecular Profiling
• Precision Medicine in Cardio-Oncology: Opportunities and Challenges

Chapter 11: Advances in Cardio-Oncology Research

• Ongoing Research on Immunotherapy and Cardiac Toxicity
• Emerging Biomarkers for Early Detection of Cardiotoxicity
• New Pharmacological Interventions for Preventing and Treating Cardiotoxicity
• The Future of Cardio-Oncology: Advancements and New Treatment Modalities

Chapter 12: Case Studies in Cardio-Oncology

• Case 1: Managing Myocarditis After Immune Checkpoint Inhibition
• Case 2: Hypertension and Cardiovascular Monitoring During Immunotherapy
• Case 3: Long-Term Cardiac Care in Cancer Survivors on Immunotherapy
• Case 4: Personalized Treatment in a Patient with Preexisting Heart Disease
• Lessons Learned and Best Practices from Clinical Cases

Conclusion

• Summary of Key Takeaways
• The Importance of Cardiac Monitoring During Cancer Therapy
• Future Directions in Cardio-Oncology
• Integrating Cardiology and Oncology for Improved Patient Outcomes

Appendices

• A. Glossary of Terms in Cardio-Oncology
• B. Key Guidelines and Protocols for Cardiotoxicity Management
• C. Resources for Multidisciplinary Collaboration

References

• Bibliography of Key Studies and Research Articles

Index

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