Cardiac Motion Compensated MR Imaging and Strain Analysis of Ventricular Trabeculae 1st edition by Andrew Dowsey, Jennifer Keegan, Guang Zhong Yang ISBN 9783540757573

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ISBN 10: 
ISBN 13: 9783540757573
Author: Andrew Dowsey, Jennifer Keegan, Guang Zhong Yang

In conventional CMR, bulk cardiac motion causes target structures to move in and out of the static acquisition plane. Due to the partial volume effect, accurate localisation of subtle features through the cardiac cycle, such as the trabeculae and papillary muscles, is difficult. This problem is exacerbated by the short acquisition window necessary to avoid motion blur and ghosting, especially during early systole. This paper presents an adaptive imaging approach with COMB multi-tag tracking that follows true 3D motion of the myocardium so that the same tissue slice is imaged throughout the cine acquisition. The technique is demonstrated with motion-compensated multi-slice imaging of ventricles, which allows for tracked visualisation and analysis of the trabeculae and papillary muscles for the first time. This enables novel in-vivo measurement of circumferential and radial strain for trabeculation and papillary muscle contractility. These statistics will facilitate the evaluation of diseases such as mitral valve insufficiency and ischemic heart disease. The adaptive imaging technique will also have significant implications for CMR in general, including motion-compensated quantification of myocardial perfusion and blood flow, and motion-correction of sequences with long acquisition windows.

Cardiac-Motion Compensated MR Imaging and Strain Analysis of Ventricular Trabeculae 1st Table of contents:

• Preliminaries
  2.1 Cardiac Imaging: Overview and Importance
  2.2 Magnetic Resonance Imaging (MRI) in Cardiology
  2.3 Ventricular Trabeculae: Anatomy and Function
  2.4 Strain Analysis in Cardiac Tissue

• Cardiac Motion Compensation in MRI
  3.1 Sources of Motion in Cardiac MRI
  3.2 Techniques for Motion Compensation
  3.3 Challenges in Compensating for Cardiac Motion
  3.4 Integration of Motion Compensation in MRI Sequences

• Ventricular Trabeculae and Strain Analysis
  4.1 Structural Properties of the Ventricular Trabeculae
  4.2 The Role of Trabeculae in Cardiac Function
  4.3 Methods for Strain Measurement in Cardiac Tissue
  4.4 Strain Analysis Techniques: Finite Strain Theory and Imaging Methods

• Methodology: Cardiac-Motion Compensated Imaging and Strain Analysis
  5.1 Image Acquisition: MRI Protocols and Parameters
  5.2 Motion Compensation Algorithms and Techniques
  5.3 Strain Mapping and Quantification Methods
  5.4 Data Processing and Analysis Pipeline

• Results: Cardiac-Motion Compensated MR Imaging and Strain Analysis
  6.1 Evaluation of Motion Compensation Efficiency
  6.2 Strain Analysis of Ventricular Trabeculae
  6.3 Comparison with Traditional MRI Techniques
  6.4 Quantitative Results and Statistical Analysis

• Applications and Clinical Relevance
  7.1 Clinical Implications of Accurate Motion Compensation
  7.2 Impact on Diagnosis and Treatment of Cardiac Diseases
  7.3 Potential Applications in Cardiac Remodeling and Heart Failure
  7.4 Future Directions for Clinical Use of Strain Analysis

• Discussion
  8.1 Insights from Motion Compensation and Strain Analysis
  8.2 Limitations and Potential Sources of Error
  8.3 Open Problems in Cardiac MRI and Strain Quantification
  8.4 Future Research Directions

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