Cancer Gene Networks 1st Edition by Usha Kasid, Robert Clarke ISBN 1493965379 9781493965373

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ISBN 10:       1493965379
ISBN 13: 978-1493965373
Author:         Usha Kasid, Robert Clarke

This volume is a valuable and timely resource for a broad audience with interests in basic and translational cancer biology, cancer drug development, as well as in the practice of personalized oncology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Cancer Gene Networks aims to ensure successful results in the further study of this evolving and vital field. Ultimately these efforts will guide development of transformative strategies for cancer diagnosis and treatment.

Cancer Gene Networks 1st Table of contents:

1. Introduction

   • Overview of Cancer Research and Drug Discovery
   • Key Challenges and Approaches

2. Cancer Gene Networks

   • Understanding Gene Networks in Cancer
   • Role in Tumorigenesis and Therapy Development

3. Emerging Methods in Chemoproteomics with Relevance to Drug Discovery

   • Overview of Chemoproteomics Techniques
   • Applications in Target Identification and Drug Development

4. ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities

   • Role of ANXA7 in Cancer Suppression
   • Mechanisms and Potential for Targeted Therapies

5. Experimental and Study Design Considerations for Uncovering Oncometabolites

   • Importance of Oncometabolites in Cancer Research
   • Study Design Considerations for Metabolomic Profiling

6. Targeting Deubiquitinating Enzymes and Autophagy in Cancer

   • Role of Deubiquitinating Enzymes in Tumor Progression
   • Autophagy Modulation for Cancer Therapy

7. Quantitative Clinical Imaging Methods for Monitoring Intratumoral Evolution

   • Advances in Imaging Technologies
   • Monitoring Tumor Evolution and Therapy Response

8. Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression

   • Transcriptome and Proteome Profiling
   • Insights into Molecular Determinants of Cancer Progression

9. Network-Oriented Approaches to Anti-Cancer Drug Response

   • Systems Biology and Drug Response
   • Network-Based Models for Drug Sensitivity Prediction

10. CRISPR/Cas-Mediated Knockin in Human Pluripotent Stem Cells

    • CRISPR/Cas Technology for Gene Editing
    • Applications in Cancer Research

11. Complete Transcriptome RNA-Seq

    • Introduction to RNA-Seq Techniques
    • Applications in Cancer Transcriptomics

12. Computational Methods and Correlation of Exon-Skipping Events with Splicing, Transcription, and Epigenetic Factors

    • Computational Tools for Splicing Analysis
    • Link Between Exon-Skipping and Epigenetic Regulation

13. Tissue Engineering Platforms to Replicate the Tumor Microenvironment of Multiple Myeloma

    • Engineering Tumor Models for Drug Testing
    • Applications in Multiple Myeloma Research

14. microRNA Target Prediction

    • Approaches to Predicting microRNA Targets
    • Role of microRNAs in Cancer Regulation

15. Evaluating the Delivery of Proteins to the Cytosol of Mammalian Cells

    • Methods for Protein Delivery to Cells
    • Applications in Cancer Therapy

16. Validation of Biomarker Proteins using Reverse Capture Protein Microarrays

    • Protein Microarray Techniques for Biomarker Discovery
    • Validation and Applications in Cancer Diagnosis

17. Chemical Synthesis of Activity-Based Diubiquitin Probes

    • Synthesis of Activity-Based Probes for Ubiquitination
    • Applications in Cancer Therapy

18. Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α

    • Role of IRE1α in Cancer
    • Profiling Enzymatic Activities for Therapeutic Targeting
19.  

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