Calcium A Matter of Life or Death 1st edition by Joachim Krebs, Marek Michalak ISBN 0444528059 9780444528056

Calcium A Matter of Life or Death 1st edition by Joachim Krebs, Marek Michalak – Ebook PDF Instant Download/Delivery. 0444528059, 978-0444528056
Full download Calcium A Matter of Life or Death 1st Edition after payment

Product details:

ISBN 10:       0444528059
ISBN 13: 978-0444528056
Author:        Joachim Krebs, Marek Michalak

Calcium A Matter of Life or Death 1st Table of contents:

Part 1: History and Evolution of Calcium Biochemistry

• Chapter 1: The Unusual History and Unique Properties of the Calcium Signal

  • This chapter explores the fundamental principles of calcium signaling, its dual role as both a first and second messenger, and its autoregulatory properties. It also covers diseases caused by defects in calcium sensor proteins such as gelsolin, annexins, calpains, neuronal calcium sensor proteins, and calcium channelopathies.

• Chapter 2: The Evolution of the Biochemistry of Calcium

  • This chapter discusses the history of calcium biochemistry from its basic inorganic chemistry to its role in early life forms (e.g., prokaryotes and eukaryotes). It covers calcium’s emergence in multicellular organisms, the evolution of calcium-binding proteins, and its connections to other metal ions, all the way through to its significance in humans.

Part 2: Structural and Functional Aspects of Calcium-Binding Proteins

• Chapter 3: Calcium-Binding Proteins and the EF-Hand Principle

  • A detailed discussion of the EF-hand motif in calcium-binding proteins, including both extracellular and intracellular proteins. It explores specific proteins like parvalbumin, calbindin, calmodulin, troponin C, and the S100 protein family, among others.

• Chapter 4: Structural Aspects of Calcium-Binding Proteins and Their Interactions with Targets

  • This chapter elaborates on the structural properties of calcium-binding proteins like calmodulin, neuronal calcium sensor proteins, and S100 proteins. It also examines the mechanisms by which these proteins interact with target proteins and the role of structural topology in these interactions.

Part 3: Calcium Homeostasis of Cells and Organelles

• Chapter 5: Voltage-Gated Calcium Channels, Calcium Signaling, and Channelopathies

  • Focuses on the structural and functional aspects of various types of voltage-gated calcium channels (L-type, T-type, P/Q-type), their roles in cellular activities such as excitation-contraction coupling, and the diseases linked to mutations in these channels.

• Chapter 6: Exchangers and Ca2+ Signaling

  • This chapter discusses the family of sodium-calcium exchangers (NCX) and their roles in cellular calcium signaling, focusing on their structural aspects and tissue-specific expression.

• Chapter 7: The Plasma Membrane Calcium Pump

  • A detailed overview of the plasma membrane calcium pump, its structural and regulatory features, splicing variants, and its association with diseases like hereditary deafness.

• Chapter 8: Endoplasmic Reticulum Dynamics and Calcium Signaling

  • This chapter explores how the ER functions as a key organelle for calcium buffering and signaling, as well as its interactions with other cellular systems like mitochondria.

• Chapter 9: Structural Aspects of Ion Pumping by Ca2+-ATPase of Sarcoplasmic Reticulum

  • It delves into the architecture and function of Ca2+-ATPase, a critical pump in muscle cells, for calcium ion transport and regulation.

• Chapter 10: Ca2+/Mn2+ Pumps of the Golgi Apparatus and Hailey–Hailey Disease

  • Discusses the role of calcium and manganese in the Golgi apparatus and their relevance to enzymatic activities, protein trafficking, and the pathophysiology of Hailey–Hailey disease.

• Chapter 11: IP3 Receptors and Their Role in Cell Function

  • Focuses on the inositol 1,4,5-trisphosphate (IP3) receptor, its structure, activation, and role in intracellular calcium release, especially in processes like fertilization, development, and secretion.

• Chapter 12: Ryanodine Receptor Structure, Function, and Pathophysiology

  • Analyzes the ryanodine receptor (RyR) isoforms, their role in excitation-contraction coupling, and associated pathophysiologies, including heart failure and neuromuscular disorders.

Part 4: Modulation of Calcium Functions

• Chapter 13: The Calcium/Calmodulin-Dependent Protein Kinase Cascades

  • Explores the calcium/calmodulin-dependent protein kinase (CaMK) pathways and how these signaling cascades regulate various cellular processes, including their activation mechanisms and key molecules like CaMKK.

• Chapter 14: The Ca2+/Calcineurin/NFAT Signaling Pathway

  • Focuses on the Ca2+–calcineurin–NFAT pathway, critical in immune cell activation, gene expression, and disease regulation, and examines the role of STIM, Orai, and CRAC channels in calcium signaling.

• Chapter 15: Temporal and Spatial Regulation of Calcium-Dependent Transcription

  • Examines how calcium oscillations regulate transcription factors such as CREB, NFAT, and NFkB, and the spatial-temporal patterns that influence gene expression.

• Chapter 16: Calcium and Fertilization

  • Discusses the crucial role of calcium in sperm activation and egg fertilization, including the mechanisms by which calcium signals regulate fertilization in both mammals and echinoderms.

• Chapter 17: Ca2+ Signaling During Embryonic Cytokinesis in Animal Systems

  • Analyzes the role of calcium signaling in cytokinesis across different species and developmental stages, focusing on how calcium transients regulate the cell division process.

• Chapter 18: Mitochondrial Ca2+ and Cell Death

  • Investigates the role of mitochondrial calcium in regulating cell death pathways, including its connection to apoptosis and the early Bcl-2-linked events.

Part 5: Calcium, a Signal in Time and Space

• Chapter 19: Calcium Signaling, a Spatiotemporal Phenomenon
  • This final chapter discusses the complex spatiotemporal dynamics of calcium signaling, including mechanisms like store-operated calcium entry (SOCE) and calcium-induced calcium release (CICR), as well as the roles of calcium buffers and the organization of calcium signals in time and space.

People also search for :

this is a matter of life and death
a matter of life and death – watch online
calcium state of matter at room temperature
what state of matter is calcium found in
gravimetric determination of calcium in a supplement