Brody’s Human Pharmacology 6th edition by Lynn Wecker ISBN‎ 032347652X 978-0323476522

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ISBN 10: 032347652X 
ISBN 13: 978-0323476522
Author: Lynn Wecker 

Focusing on the essential aspects of pharmacology you need to know, Brody‘s Human Pharmacology, 6th Edition, keeps you fully up to date with all that’s new in the field. Streamlined content, a new organizational approach, enhanced online components, and thoroughly updated information ensure your grasp of key concepts and prepare you for exams. Nearly 500 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names reinforce your mastery of the information.

The 6th Edition of this easy-to-use text is now fully up to date with:

• NEW chapter devoted entirely to pharmacogenomics and personalized medicine.
• NEW chapter on cannabinoids and their use for pain and other disorders, in light of recent legalization in many states.
• NEW chapters on recent developments in the treatment of Alzheimer’s disease, ADHD and the latest treatments for HIV.
• NEW section on pain management.
• NEW section in each chapter covering “Clinical Relevance for Healthcare Professionals” that provides important information specific to physical therapists, dentists and dental hygienists, and many other medical professionals.

Plus these student-friendly features:

• A new organizational approach, focusing on integration and systems-based learning.
• Contributions from leading faculty who cover the most important aspects of pharmacology necessary for a basic understanding of the subject, including concepts, clinical applications, and side effects.
• USMLE-style self-assessment questions at the end of every chapter, answers and rationales in the Appendix.
• Online access to Student Consult―where you’ll find the complete contents of the book, fully searchable…150 USMLE-style questions…and more.

Brody’s Human Pharmacology 6th Table of contents:

Section 1: General Principles of Pharmacology

1. Introduction to Pharmacology
   • What is pharmacology?
   • The importance of pharmacology in medicine
   • Overview of drug development and regulation
2. Basic Principles of Drug Action
   • Mechanisms of drug action at the molecular level
   • Receptor theory
   • Drug-receptor interactions and affinity
   • Dose-response relationships
3. Pharmacokinetics
   • Absorption, distribution, metabolism, and excretion of drugs (ADME)
   • Bioavailability and first-pass metabolism
   • Pharmacokinetic models and drug half-life
   • Factors affecting drug pharmacokinetics (e.g., age, genetics)
4. Pharmacodynamics
   • How drugs produce their effects on the body
   • Drug-receptor interactions
   • Therapeutic and toxic effects
   • Dose-response curves and therapeutic windows
5. Drug Metabolism and Excretion
   • Liver metabolism and cytochrome P450 enzymes
   • Renal excretion and other routes of elimination
   • Factors affecting metabolism (e.g., liver function, age, drug interactions)

Section 2: Autonomic Pharmacology

6. Autonomic Nervous System Overview
   • Anatomy and physiology of the autonomic nervous system
   • Sympathetic and parasympathetic systems
   • Neurotransmitters and receptors in autonomic pharmacology
7. Adrenergic Drugs
   • Sympathomimetic drugs (agonists)
   • Sympatholytic drugs (antagonists)
   • Clinical uses of adrenergic drugs (e.g., in shock, asthma, hypertension)
8. Cholinergic Drugs
   • Cholinergic agonists and antagonists
   • Clinical uses of cholinergic drugs (e.g., in glaucoma, myasthenia gravis)
   • Parasympathomimetic and parasympatholytic agents

Section 3: Cardiovascular Pharmacology

9. Drugs Affecting the Heart
   • Antiarrhythmic drugs
   • Inotropic drugs (e.g., digoxin)
   • Drugs for heart failure management
10. Vascular Drugs

• Antihypertensive drugs
• Vasodilators and their clinical uses
• Calcium channel blockers, ACE inhibitors, and diuretics

11. Anticoagulants and Antiplatelet Drugs

• Anticoagulants (e.g., warfarin, heparin)
• Antiplatelet drugs (e.g., aspirin, clopidogrel)
• Fibrinolytics and their role in thrombotic disorders

Section 4: Central Nervous System Pharmacology

12. Neurotransmission in the CNS

• Overview of neurotransmitters in the brain (e.g., dopamine, serotonin, GABA)
• Drug actions on neurotransmitter systems

13. Drugs in Psychiatric Disorders

• Antidepressants (e.g., SSRIs, tricyclics)
• Antipsychotic drugs (e.g., typical and atypical antipsychotics)
• Anxiolytics and mood stabilizers

14. Analgesics and Antiepileptic Drugs

• Opioid analgesics (e.g., morphine, fentanyl)
• Non-opioid analgesics (e.g., NSAIDs)
• Antiepileptic drugs (e.g., phenytoin, valproate)

15. General Anesthesia

• Mechanism of action of anesthetic agents
• Inhalational and intravenous anesthetics
• Clinical considerations and side effects

Section 5: Endocrine Pharmacology

16. Hormonal Drugs

• Insulin and other agents for diabetes management
• Thyroid hormones and antithyroid drugs
• Corticosteroids and their clinical uses

17. Drugs Affecting Reproductive Function

• Contraceptive drugs and their mechanisms
• Hormone replacement therapy (HRT)
• Drugs for infertility and other reproductive disorders

18. Drugs Affecting Bone and Calcium Metabolism

• Osteoporosis treatments (e.g., bisphosphonates, calcitonin)
• Drugs for hypercalcemia and hypocalcemia

Section 6: Gastrointestinal Pharmacology

19. Drugs for Gastrointestinal Disorders

• Proton pump inhibitors (PPIs) and H2 blockers for acid reflux
• Laxatives and antiemetic agents
• Drugs for inflammatory bowel disease (e.g., corticosteroids, immunosuppressants)

20. Antidiarrheal and Antacids

• Drugs for treating diarrhea and constipation
• Antacids and drugs for peptic ulcer disease

Section 7: Renal and Respiratory Pharmacology

21. Renal Pharmacology

• Diuretics and their uses
• Drugs for managing renal failure
• Drugs affecting renal electrolyte balance

22. Respiratory Pharmacology

• Bronchodilators (e.g., beta-agonists, anticholinergics)
• Drugs for asthma and chronic obstructive pulmonary disease (COPD)
• Antihistamines and decongestants

Section 8: Chemotherapy and Immunopharmacology

23. Chemotherapy Pharmacology

• Mechanisms of action of anticancer drugs
• Types of chemotherapy agents (alkylating agents, antimetabolites, etc.)
• Chemotherapy side effects and management

24. Immunopharmacology

• Immunosuppressive drugs (e.g., cyclosporine)
• Biologic agents and monoclonal antibodies
• Vaccines and immunomodulatory drugs

Section 9: Drug Interactions and Toxicology

25. Drug Interactions

• Mechanisms of drug interactions
• Common drug-drug interactions
• Clinical implications of drug interactions

26. Toxicology and Adverse Effects

• Types of adverse drug reactions (ADRs)
• Managing drug toxicity
• Organ-specific toxicity (e.g., hepatotoxicity, nephrotoxicity)

Section 10: Special Populations

27. Pharmacology in Special Populations

• Pharmacokinetics in pediatric and geriatric patients
• Pregnancy and lactation considerations in drug therapy
• Pharmacogenomics and personalized medicine

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