Bone Marrow Diagnosis An Illustrated Guide 3rd edition by Kevin Gatter, David Browwn ISBN 1118253655 1118253655

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ISBN 10: 1118253655
ISBN 13: 1118253655
Author:  Kevin Gatter,David Browwn

Bone Marrow Diagnosis, Third Edition, is an essential resource for pathologists and haematologists who need to report bone marrow trephine biopsies.

Practical and highly illustrated this edition has been comprehensively updated whilst remaining succinct and concentrating on the core information necessary to make an accurate diagnosis.

The text provides comparisons of the common methods of sample collection, fixation and staining, and a clear description of how to examine a trephine section. Applying a consistent approach, the chapters cover the range of disorders of bone marrow, discussing the clinical features, histopathology of bone marrow and diagnostic problems of each condition. Each chapter closes with a summary of key points and each diagnostic entity is accompanied by high quality images, over 900 in all, showing typical and more unusual examples of histological features.

This compact text, oriented at diagnosis and comprehensively accompanied by usable illustrations, is an invaluable reference tool for the trainee and practicing histopathologists, pathologists and haematologists.

• A practical guide aimed at allowing a busy pathologist to easily find the essential description and illustration of the most common bone marrow diseases seen in trephines
• Covers new treatment for chronic myeloid leukaemia, B-cell lymphoma and antibody treatments
• High quality colour images accompany each diagnostic entity
• Coverage of cytology in sections relating to myeloid dysplasias and acute leukaemias
• Addresses lymphoma categorization and individual lymphoma entities
• Incorporates new WHO classifications of lymphomas and leukaemias

Bone Marrow Diagnosis: An Illustrated Guide  3rd Table of contents:

Section 1: Introduction to Bone Marrow Diagnosis

1. Basic Principles of Bone Marrow Examination

   • Indications for bone marrow biopsy and aspiration
   • Procedure for obtaining bone marrow samples
   • Preparation and processing of bone marrow specimens

2. Normal Bone Marrow

   • Morphology of normal bone marrow cells
   • Hematopoiesis and stages of blood cell development
   • Bone marrow architecture and histological features

Section 2: Hematologic Disorders

3. Anemia and Red Blood Cell Disorders

   • Hypoproliferative vs. hyperproliferative anemias
   • Bone marrow findings in different types of anemia (e.g., iron deficiency, megaloblastic anemia)
   • Hemolytic anemia and bone marrow response

4. Leukopenia and Leukocyte Disorders

   • Bone marrow involvement in neutropenia, leukopenia, and other white blood cell disorders
   • Disorders such as leukemia and lymphoma
   • Myelodysplastic syndromes and their bone marrow features

5. Thrombocytopenia and Platelet Disorders

   • Bone marrow findings in thrombocytopenia
   • Platelet disorders and thrombocytosis
   • Role of bone marrow in regulating platelet production

Section 3: Myeloproliferative and Myelodysplastic Disorders

6. Myeloproliferative Neoplasms

   • Chronic myelogenous leukemia (CML)
   • Polycythemia vera, essential thrombocythemia, and primary myelofibrosis
   • Bone marrow findings in these conditions

7. Myelodysplastic Syndromes

   • Features of myelodysplastic syndromes in bone marrow
   • Morphologic assessment of dysplasia
   • Risk stratification and prognosis

Section 4: Leukemias and Lymphomas

8. Acute Leukemias

   • Acute myeloid leukemia (AML) and its classification
   • Acute lymphoblastic leukemia (ALL)
   • Bone marrow findings in acute leukemias

9. Chronic Leukemias

   • Chronic lymphocytic leukemia (CLL)
   • Chronic myelogenous leukemia (CML) in detail
   • Bone marrow involvement in chronic leukemias

10. Lymphomas and Bone Marrow Involvement

    • Diagnosis of lymphoma with bone marrow biopsy
    • Bone marrow assessment in Hodgkin lymphoma and non-Hodgkin lymphoma

Section 5: Hematologic Malignancies

11. Plasma Cell Disorders

    • Multiple myeloma, plasmacytosis, and bone marrow changes
    • Waldenström’s macroglobulinemia and its marrow presentation

12. Bone Marrow Infiltration by Solid Tumors

    • Infiltration of the bone marrow by metastases from solid tumors (e.g., breast, prostate, lung cancers)
    • Diagnosis and differentiation of marrow involvement

Section 6: Bone Marrow Failure Syndromes

13. Aplastic Anemia

    • Etiology and pathophysiology of aplastic anemia
    • Bone marrow findings and diagnostic criteria

14. Hypoplastic Bone Marrow

    • Bone marrow hypoplasia and causes
    • Differential diagnosis and management

Section 7: Special Topics

15. Bone Marrow in Systemic Diseases

    • Bone marrow findings in systemic infections (e.g., tuberculosis, fungal infections)
    • Bone marrow changes in autoimmune diseases (e.g., lupus)

16. Bone Marrow Transplantation and Hematopoietic Stem Cell Therapy

    • Bone marrow biopsy in transplant patients
    • Post-transplant marrow evaluation and complications (e.g., graft vs. host disease)

Section 8: Diagnostic Techniques

17. Histology and Immunohistochemistry

    • Use of immunohistochemical markers in bone marrow diagnosis
    • Morphological examination and correlation with immunophenotyping
    • Flow cytometry in bone marrow diagnostics

18. Molecular Diagnostics

    • Role of molecular testing (e.g., genetic mutations, cytogenetic analysis)
    • How molecular findings correlate with bone marrow pathology

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