Bone and Joint Infections From Microbiology to Diagnostics and Treatment 2nd Edition by Werner Zimmerli ISBN 1119720680 9781119720683

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ISBN 10: 1119720680 
ISBN 13: 9781119720683
Author: Werner Zimmerli

In the newly revised Second Edition of Bone and Joint Infections: From Microbiology to Diagnostics and Treatment, accomplished researcher and author Werner Zimmerli delivers a comprehensive overview of the most recent developments in the subject of bone and joint infection. Covering much of the new information appearing over the last five years, the book includes four new chapters presenting the diagnostic approach in bone and joint infections, discussing the identification of pathogens by non-culture techniques, management of multi-resistant bacteria in bone and joint infections ­by bacteriophages, and unusual microorganisms in periprosthetic joint infections.

Many of the chapters are also updated to include new information on topics like eubacterial PCR, multiplex PCR, and the shotgun metagenomics approach. These subjects are of increased applicability and interest to increase the fraction of cases with identified pathogens. The book also helps clinicians to understand MRI-based images and rapidly interpret and plan for comprehensive therapy.

Readers will also benefit from the inclusion of:

• A thorough introduction to the pharmacokinetics and pharmacodynamics of antibiotics in bone and preclinical models of infection in bone and joint surgery
• An exploration of native joint arthritis in children and adults, as well as an overview of septic arthritis of axial joints
• A practical discussion of the general aspects of periprosthetic joint infection, as well as specific aspects of periprosthetic joint infection after total hip and knee, shoulder, elbow, and ankle arthroplasty
• A concise treatment of osteomyelitis in children and adults

Perfect for infectious disease specialists, microbiologists, orthopedic and trauma surgeons, and internists, Bone and Joint Infections: From Microbiology to Diagnostics and Treatment will also earn a place in the libraries of professionals working in the implant industry and pharmaceuticals, as well as clinical pharmacologists and rheumatologists.

Bone and Joint Infections From Microbiology to Diagnostics and Treatment 2nd Table of contents:

Chapter 1: Introduction
References
Chapter 2: Diagnostic Approach in Bone and Joint Infections
Introduction
Common Microorganisms Causing Bone and Joint Infection
Diagnostic Approach in Spinal Infection
Diagnostic Approach in Bone Fixation Device‐Associated Infection
Diagnostic Approach in Native Arthritis and Infections after Anterior Cruciate Ligament Repair (ACL‐R)
Diagnostic Approach in Periprosthetic Joint Infections (PJI)
Key Points
References
Chapter 3: Unusual Microorganisms in Periprosthetic Joint Infection
Introduction
Gram‐Positive Microorganisms
Gram‐Negative Microorganisms
Zoonotic Microorganisms
Anaerobic Microorganisms
Mycobacteria
Other Microorganisms
Key Points
References
Chapter 4: Identification of Pathogens in Bone and Joint Infections by Non‐Culture Techniques
Introduction
Broad‐Range PCR
Targeted PCR
Multiplex PCR
Next‐Generation Sequencing Approach
Mass Spectrometry‐Based Methods
Key Points (Figure 4.5)
References
Chapter 5: Bacteriophages for Treatment of Biofilm Infections
History of Bacteriophage Use in Human Infections
Principles of Bacteriophage Therapy
Activity of Bacteriophages against Bacterial Biofilms and Persisters
Bacteriophage Susceptibility Testing: the Phagogram
Experimental and Clinical Evidence with Bacteriophage Treatment
Local Delivery and Systemic Bacteriophage Application
Outlook and Future Perspectives
Key Points
References
Chapter 6: Pharmacokinetics and Pharmacodynamics of Antibiotics in Bone
Pharmacokinetics
Bone Sample Preparation and Analysis
Pharmacokinetic Sampling and Data Analysis
Penetration of Antibiotics into Bone
Pharmacodynamics and Monte Carlo Simulations
Conclusions
Key Points
References
Chapter 7: Preclinical Models of Infection in Bone and Joint Surgery
Introduction
Influence of Species in Preclinical Models of Bone and Joint Infection
Overview of Animal Models
Direct Inoculation with Minimal Trauma
Animal Models of Bone and Joint Infection Incorporating Trauma
Hematogenous Models
Future Directions
Conclusions
Key Points
References
Chapter 8: Native Joint Arthritis in Children
Introduction
Epidemiology
Microbiology
Pathogenesis
Clinical Presentation
Laboratory Investigation
Imaging Studies
Differential Diagnosis
Treatment
Prognosis
Key Points
References
Chapter 9: Native Joint Arthritis in Adults
Introduction
Risk Factors
Pathogenesis, Epidemiology, and Microbiology
Diagnosis
Treatment
Outcome
Key Points
Acknowledgments
References
Chapter 10: Septic Arthritis of Axial Joints
Septic Arthritis of the Sternoclavicular Joint
Key Points
Septic Arthritis of the Symphysis Pubis
Key Points
Septic Arthritis of the Sacroiliac Joint
Key Points
References
Chapter 11: Periprosthetic Joint Infection
Introduction
Definition
Classification
Pathogenesis
Laboratory Investigation
Therapeutic Management
Prophylaxis
Errors in the Management of PJI
Key Points
References
Chapter 12: Periprosthetic Joint Infection after Total Hip and Knee Arthroplasty
Introduction
Risk Factors
Microbiology
Clinical Features
Laboratory Investigation
Imaging Procedures
Management
Instructive Cases
References
Chapter 13: Periprosthetic Joint Infection after Shoulder Arthroplasty
Introduction
Risk Factors
Microbiology
Pathogenesis
Clinical Features
Laboratory Investigation
Imaging Procedures
Management
Instructive Cases
References
Chapter 14: Periprosthetic Joint Infection after Elbow Arthroplasty
Introduction
Microbiology
Clinical Features
Diagnostic Procedures
Management
Instructive Cases
References
Chapter 15: Periprosthetic Joint Infection after Ankle Arthroplasty
Introduction
Risk Factors
Microbiology
Clinical Features
Laboratory Investigation
Imaging Procedures
Management
Instructive Cases
References
Chapter 16: Osteomyelitis: Classification
Classification According to Pathogenesis
Classification According to the Duration of Infection
Classification According to the Localization
Classification According to the Presence of an Implant
Classification According to Anatomy and Comorbidity
References
Chapter 17: Osteomyelitis in Children
Introduction
Epidemiology
Pathophysiology
Clinical Presentation, Diagnosis, and Microbiology
Treatment
Complications
Key Points
References
Chapter 18: Acute Osteomyelitis in Adults
Introduction
Pathogenesis
Epidemiology
Microbiology
Risk Factors
Clinical Features
Laboratory Investigation
Imaging Procedures
Clinical and Imaging Differential Diagnosis
Treatment
Key Points
References
Chapter 19: Subacute Osteomyelitis
Introduction
Epidemiology
Clinical Features
Laboratory Investigation
Imaging Procedures
Antimicrobial and Surgical Therapy
Key Points
References
Chapter 20: Chronic Osteomyelitis in Adults
Introduction
Pathogenesis
Diagnosis
Treatment
Key Points
Acknowledgments
References
Chapter 21: Diabetic Foot Osteomyelitis
Introduction
Classification
Microbiology
Risk Factors
Clinical Features
Inflammatory Parameters
Imaging Procedures
Treatment
Prevention
References
Chapter 22: Osteomyelitis of the Jaws
Introduction
Classification
Microbiology
Risk Factors
Clinical Features
Laboratory Investigation
Imaging Procedures
Management
Key Points
References
Chapter 23: Fracture‐Related Infection of the Long Bones
Introduction
Classification and Risk Factors
Microbiology
Clinical Features
Laboratory Investigation
Imaging Procedures
Management
Instructive Cases
References
Chapter 24: Implant‐Associated Vertebral Osteomyelitis
Introduction
Classification and Risk Factors
Microbiology
Clinical Features
Diagnostic Procedures
Treatment
Instructive Cases
References
Chapter 25: Postoperative Sternal Osteomyelitis
Introduction
Risk Factors
Microbiology
Clinical Features
Laboratory Investigation
Imaging Procedures
Management
Instructive Cases
References
Index
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