Biological Inorganic Chemistry An Introduction 1st Edition by Robert Crichton 0444527400 9780444527400
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Authors:Robert R. Crichton , Series:Medicine [7] , Tags:Science; Chemistry; Inorganic; Life Sciences; Biochemistry; Medical; General; Analytic; Organic; Technology & Engineering; Chemical & Biochemical , Author sort:Crichton, Robert R. , Ids:9780080556222 , Languages:Languages:eng , Published:Published:Dec 2007 , Publisher:Elsevier , Comments:Comments:The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.Many colour illustrations. Enables easier visualization of molecular mechanismsWritten by a single author. Ensures homgeneity of style and effective cross referencing between chapters
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ISBN 10: 0444527400
ISBN 13: 9780444527400
Author: Robert R. Crichton
Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.
Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.
Many colour illustrations. Enables easier visualization of molecular mechanisms
Written by a single author. Ensures homgeneity of style and effective cross referencing between chapters
Biological Inorganic Chemistry An Introduction 1st Table of contents:
Chapter 1. An Overview of Metals in Biology
Introduction
Why do we Need Anything Other Than C, H, N and O (Together with Some P And S)?
What are the Essential Metal Ions?
References
Chapter 2. Basic Coordination Chemistry for Biologists
Introduction
Hard and Soft Ligands
Coordination Geometry
Crystal Field Theory and Ligand Field Theory
References
Chapter 3. Biological Ligands for Metal Ions
Introduction
Protein Amino Acid Residues (and Derivatives) as Ligands
An Example of a Non-Protein Ligand: Carbonate and Phosphate
Engineering Metal Insertion Into Organic Cofactors
Chelatase: Terminal Step in Tetrapyrrole Metallation
Iron–Sulfur Cluster Containing Proteins
Iron–Sulfur Cluster Formation
Copper Insertion into Superoxide Dismutase
More Complex Cofactors: MoCo, FeMoCo, P-Clusters, H-Clusters and CuZ
Siderophores
References
Chapter 4. Structural and Molecular Biology for Chemists
Introduction
The Structural Building Blocks of Proteins
Primary, Secondary, Tertiary and Quaternary Structures of Proteins
Secondary and Tertiary Structures of Nucleic Acids
References
Chapter 5. An Overview of Intermediary Metabolism and Bioenergetics
Introduction
Redox Reactions in Metabolism
The Central Role of ATP in Metabolism
The Types of Reaction Catalysed by Enzymes of Intermediary Metabolism
An Overview of Intermediary Metabolism: Catabolism
Selected Case Studies: Glycolysis and the Tricarboxylic Acid Cycle
An Overview of Intermediary Metabolism: Anabolism
Bioenergetics: Generation of Phosphoryl Transfer Potential at the Expense of Proton Gradients
References
Chapter 6. Methods to Study Metals in Biological Systems
Introduction
Magnetic Properties
Electron Paramagnetic Resonance (EPR) Spectroscopy
Mössbauer Spectroscopy
NMR Spectroscopy
Electronic and Vibrational Spectroscopies
Circular Dichroism and Magnetic Circular Dichroism
Resonance Raman Spectroscopy
Extended X-Ray Absorption Fine Structure
X-Ray Diffraction
References
Chapter 7. Metal Assimilation Pathways
Introduction
Metal Assimilation in Bacteria
Metal Assimilation in Plants and Fungi
Metal Assimilation in Mammals
References
Chapter 8. Transport, Storage and Homeostasis of Metal Ions
Introduction
Metal Storage and Homeostasis in Bacteria
Metal Transport, Storage and Homeostasis in Plants and Fungi
Metal Transport, Storage and Homeostasis in Mammals
References
Chapter 9. Sodium and Potassium„Channels and Pumps
Introduction: „Transport Across Membranes
Sodium Versuspotassium
Sodium Channels
References
Chapter 10. Magnesium–Phosphate Metabolism and Photoreceptors
Introduction
Magnesium-Dependent Enzymes
Phosphoryl Group Transfer: Kinases
Phosphoryl Group Transfer: Phosphatases
Stabilization of Enolate Anions: The Enolase Super Family
Enzymes of Nucleic Acid Metabolism
Magnesium and Photoreception
References
Chapter 11. Calcium: Cellular Signalling
Introduction: „Comparison of Ca2+ and Mg2+
The Discovery of a Role for Ca2+ Other Than as a Structural Component.
Plasma Membrane Uptake Pathways
Calcium Export from Cells
CA2+ Transport Across Intracellular Membranes
Ca2+ and Cell Signalling
References
Chapter 12. Zinc: Lewis Acid and Gene Regulator
Introduction
Mononuclear Zinc Enzymes
Carbonic Anhydrase
Carboxypeptidases and Thermolysins
Alcohol Dehydrogenases
Other Mononuclear Zinc Enzymes
Multinuclear and Cocatalytic Zinc Enzymes
Zinc Fingers – DNA- and RNA-Binding Motifs
References
Chapter 13. Iron: Essential for Almost All Life
Introduction
Iron and Oxygen
The Biological Importance of Iron
Biological Functions of Iron-Containing Proteins
Haemoproteins
Iron–Sulfur Proteins
Other Iron-Containing Proteins
References
Chapter 14. Copper: Coping with Dioxygen
Introduction
Blue Copper Proteins Involved in Electron Transport
Copper-Containing Enzymes in Oxygen Activation and Reduction
Copper Enzymes Involved with Other Low-Molecular Weight Substrates
Mars and Venus: The Role of Copper in Iron Metabolism
References
Chapter 15. Nickel and Cobalt: Evolutionary Relics
Introduction: Comparison of Nickel and Cobalt
Nickel Enzymes
Methyl-Coenzyme M Reductase
Cobalamine and Cobalt Proteins
B12-Dependent Isomerases
B12-Dependent Methyltransferases
Non-Corrin Co-Containing Enzymes
References
Chapter 16. Manganese: Water Splitting, Oxygen Atom Donor
Introduction: Manganese Chemistry
Mn2+ and Detoxification of Oxygen Free Radicals
Non-Redox Di-Mn Enzymes: Arginase
Photosynthetic Oxidation of Water: Oxygen Evolution
References
Chapter 17. Molybdenum, Tungsten, Vanadium and Chromium
Introduction
Molybdenum and Tungsten
Molybdenum Enzyme Families
Tungsten Enzymes
Nitrogenases
Vanadium Biochemistry
Vanadium Biology
Chromium in Biology
References
Chapter 18. Metals in Brain and Their Role in Various Neurodegenerative Diseases
Introduction: Metals in Brain
Calcium
Zinc
Copper
Disorders of Copper Metabolism: Wilson’s and Menkes Diseases
Aceruloplasminaemia
Creutzfeldt–Jakob and Other Prion Diseases
Iron
Redox Metal Ions, Oxidative Stress and Neurodegenerative Diseases
References
Chapter 19. Biomineralization
Introduction
Iron Deposition in Ferritin
Calcium-Based Biominerals: Calcium Carbonates in Ascidians and Molluscs
Biomineralization in Bone and Enamel Formation
The Organic Matrix, Mineral Phase and Bone Mineralization
References
Chapter 20. Metals in Medicine and the Environment
Introduction
Metallotherapeutics with Lithium
Cisplatin: An Anti-Cancer Drug
Contrast Agents for Magnetic Resonance Imaging
Metals in the Environment
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