Bioinformatics and Biomarker Discovery Omic Data Analysis for Personalized Medicine 1st Edition by Francisco Azuaje ISBN 047074460X 978-0470744604

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Product details:

ISBN 10:       047074460X
ISBN 13: 978-0470744604
Author:         Francisco Azuaje

This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems.

The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of “omic” data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications.

Readers are provided with the knowledge needed to assess the requirements, computational approaches and outputs in disease biomarker research. Commentaries from guest experts are also included, containing detailed discussions of methodologies and applications based on specific types of “omic” data, as well as their integration. Covers the main range of data sources currently used for biomarker discovery

• Covers the main range of data sources currently used for biomarker discovery
• Puts emphasis on concepts, design principles and methodologies that can be extended or tailored to more specific applications
• Offers principles and methods for assessing the bioinformatic/biostatistic limitations, strengths and challenges in biomarker discovery studies
• Discusses systems biology approaches and applications
• Includes expert chapter commentaries to further discuss relevance of techniques, summarize biological/clinical implications and provide alternative interpretations

Bioinformatics and Biomarker Discovery: ‘‘Omic’’ Data Analysis for Personalized Medicine 1st Table of contents:

1 Biomarkers and bioinformatics

1.1 Bioinformatics, translational research and personalized medicine

1.2 Biomarkers: fundamental definitions and research principles

1.3 Clinical resources for biomarker studies

1.4 Molecular biology data sources for biomarker research

1.5 Basic computational approaches to biomarker discovery: key applications and challenges

1.6 Examples of biomarkers and applications

1.7 What is next?

2 Review of fundamental statistical concepts

2.1 Basic concepts and problems

2.2 Hypothesis testing and group comparison

2.3 Assessing statistical significance in multiple-hypotheses testing

2.4 Correlation

2.5 Regression and classification: basic concepts

2.6 Survival analysis methods

2.7 Assessing predictive quality

2.8 Data sample size estimation

2.9 Common pitfalls and misinterpretations

3 Biomarker-based prediction models: design and interpretation principles

3.1 Biomarker discovery and prediction model development

3.2 Evaluation of biomarker-based prediction models

3.3 Overview of data mining and key biomarker-based classification techniques

3.4 Feature selection for biomarker discovery

3.5 Critical design and interpretation factors

4 An introduction to the discovery and analysis of genotype-phenotype associations

4.1 Introduction: sources of genomic variation

4.2 Fundamental biological and statistical concepts

4.3 Multi-stage case-control analysis

4.4 SNPs data analysis: additional concepts, approaches and applications

4.5 CNV data analysis: additional concepts, approaches and applications

4.6 Key problems and challenges

Guest commentary on chapter 4: Integrative approaches to genotype-phenotype association discovery (Ana Dopazo)

References

5 Biomarkers and gene expression data analysis

5.1 Introduction

5.2 Fundamental analytical steps in gene expression profiling

5.3 Examples of advances and applications

5.4 Examples of the roles of advanced data mining and computational intelligence

5.5 Key limitations, common pitfalls and challenges

Guest commentary on chapter 5: Advances in biomarker discovery with gene expression data (Haiying Wang and Huiru Zheng)

Unsupervised clustering approaches

Module-based approaches

Final remarks

References

6 Proteomics and metabolomics for biomarker discovery: an introduction to spectral data analysis

6.1 Introduction

6.2 Proteomics and biomarker discovery

6.3 Metabolomics and biomarker discovery

6.4 Experimental techniques for proteomics and metabolomics: an overview

6.5 More on the fundamentals of spectral data analysis

6.6 Targeted and global analyses in metabolomics

6.7 Feature transformation, selection and classification of spectral data

6.8 Key software and information resources for proteomics and metabolomics

6.9 Gaps and challenges in bioinformatics

Guest commentary on chapter 6: Data integration in proteomics and metabolomics for biomarker discovery (Kenneth Bryan)

Data integration and feature selection

References

7 Disease biomarkers and biological interaction networks

7.1 Network-centric views of disease biomarker discovery

7.2 Basic concepts in network analysis

7.3 Fundamental approaches to representing and inferring networks

7.4 Overview of key network-driven approaches to biomarker discovery

7.5 Network-based prognostic systems: recent research highlights

7.6 Final remarks: opportunities and obstacles in network-based biomarker research

Guest commentary on chapter 7: Commentary on ‘disease biomarkers and biological interaction networks’ (Zhongming Zhao)

Integrative approaches to biomarker discovery

Pathway-based analysis of GWA data

Integrative analysis of networks and pathways

References

8 Integrative data analysis for biomarker discovery

8.1 Introduction

8.2 Data aggregation at the model input level

8.3 Model integration based on a single-source or homogeneous data sources

8.4 Data integration at the model level

8.5 Multiple heterogeneous data and model integration

8.6 Serial integration of source and models

8.7 Component- and network-centric approaches

8.8 Final remarks

Guest commentary on chapter 8: Data integration: The next big hope? (Yves Moreau )

References

9 Information resources and software tools for biomarker discovery

9.1 Biomarker discovery frameworks: key software and information resources

9.2 Integrating and sharing resources: databases and tools

9.3 Data mining tools and platforms

9.4 Specialized information and knowledge resources

9.5 Integrative infrastructure initiatives and inter-institutional programmes

9.6 Innovation outlook: challenges and progress

10 Challenges and research directions in bioinformatics and biomarker discovery

10.1 Introduction

10.2 Better software

10.3 The clinical relevance of new biomarkers

10.4 Collaboration

10.5 Evaluating and validating biomarker models

10.6 Defining and measuring phenotypes

10.7 Documenting and reporting biomarker research

10.8 Intelligent data analysis and computational models

10.9 Integrated systems and infrastructures for biomedical computing

10.10 Open access to research information and outcomes

10.11 Systems-based approaches

10.12 Training a new generation of researchers for translational bioinformatics

10.13 Maximizing the use of public resources

10.14 Final remarks

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