Bioinformatics A Practical Guide to the Analysis of Genes and Proteins 1st Edition by Andreas Baxevanis, Francis Ouellette 0471324418 978-0471324416
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Authors:Andreas D. Baxevanis; B. F. Francis Ouellette , Series:Biochemistry [2] , Tags:Computers; Data Science; General; Bioinformatics; Science; Life Sciences; Biochemistry; Research & Methodology; Molecular Biology , Author sort:Baxevanis, Andreas D. & Ouellette, B. F. Francis , Ids:9780471383901 , Languages:Languages:eng , Published:Published:May 2001 , Publisher:Wiley , Comments:Comments:”In this book, Andy Baxevanis and Francis Ouellette . . . have undertaken the difficult task of organizing the knowledge in this field in a logical progression and presenting it in a digestible form. And they have done an excellent job. This fine text will make a major impact on biological research and, in turn, on progress in biomedicine. We are all in their debt.” —Eric Lander from the Foreword Reviews from the First Edition “…provides a broad overview of the basic tools for sequence analysis … For biologists approaching this subject for the first time, it will be a very useful handbook to keep on the shelf after the first reading, close to the computer.” —Nature Structural Biology “…should be in the personal library of any biologist who uses the Internet for the analysis of DNA and protein sequence data.” —Science “…a wonderful primer designed to navigate the novice through the intricacies of in scripto analysis … The accomplished gene searcher will also find this book a useful addition to their library … an excellent reference to the principles of bioinformatics.” —Trends in Biochemical Sciences This new edition of the highly successful Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins provides a sound foundation of basic concepts, with practical discussions and comparisons of both computational tools and databases relevant to biological research. Equipping biologists with the modern tools necessary to solve practical problems in sequence data analysis, the Second Edition covers the broad spectrum of topics in bioinformatics, ranging from Internet concepts to predictive algorithms used on sequence, structure, and expression data. With chapters written by experts in the field, this up-to-date reference thoroughly covers vital concepts and is appropriate for both the novice and the experienced practitioner. Written in clear, simple language, the book is accessible to users without an advanced mathematical or computer science background. This new edition includes: All new end-of-chapter Web resources, bibliographies, and problem sets Accompanying Web site containing the answers to the problems, as well as links to relevant Web resources New coverage of comparative genomics, large-scale genome analysis, sequence assembly, and expressed sequence tags A glossary of commonly used terms in bioinformatics and genomics Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, Second Edition is essential reading for researchers, instructors, and students of all levels in molecular biology and bioinformatics, as well as for investigators involved in genomics, positional cloning, clinical research, and computational biology.
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ISBN 10: 0471324418
ISBN 13: 978-0471324416
Author: Andreas D. Baxevanis, B. F. Francis Ouellette
Bioinformatics A Practical Guide to the Analysis of Genes and Proteins Edited by Andreas D. Baxevanis and B. F. Francis Ouellette With the explosion of sequence and structural information available to researchers, the field of bioinformatics is playing an increasingly large role in the study of fundamental biological problems. The challenge facing biologists, especially in light of the vast amount of data being produced by the Human Genome Project and other systematic sequencing efforts, will be the effective utilization of sequence-based information on two fronts: first, to reveal previously unknown relationshipsranging from the identification of unknown genes to the prediction of protein structures; and, second, to use predictions and inferences made from these data to better design experiments in the laboratory as genome projects move from the realm of structural genomics into one of functional genomics. Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins makes computational biology accessible to scientists at all levels of expertise, including those with no formal computer training, by taking an example-driven approach accompanied by a large number of illustrations. By focusing in on a selected group of powerful methods, the book cuts through the overwhelming array of existing tools and databases, helping the reader quickly design and implement a successful sequence analysis strategy. Presented by leading authorities in computational biology, this edited volume covers a broad range of topics in bioinformatics, beginning with a gentle reintroduction to the use of software and Internet resources and culminating with a discussion of how readers can submit their own sequence data to the public databases. Other topics covered in this volume include:
- The GenBank sequence database
- Structural databases and basic tools for viewing three-dimensional structures
- Sequence analysis using the integrated GCG package
- Information retrieval from biological databases
- The NCBI data model
- Effective methodologies for performing sequence-based database searches
- Practical aspects of multiple sequence alignment
- Phylogenetic analysis
- Predictive methods using protein and nucleotide sequences
- Navigating public physical mapping databases
- The AceDB database for organizing and presenting genome information
Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins is fully referenced and provides appendices, a glossary, sample sequence file formats, and over 120 illustrations. This volume is a must have for molecular biologists, geneticists, biochemists, and any other biologist interested in using sequence information to advantage in the laboratory. The topics have been arranged to build upon one another so that the book can also be used in a one-semester practical course on sequence analysis and bioinformatics.
Bioinformatics A Practical Guide to the Analysis of Genes and Proteins 1st Table of contents:
The Internet and the Biologist
The GenBank Sequence Database
Structure Databases
Sequence Analysis Using GCG
Information Retrieval from Biological Databases
The NCBI Data Model
Sequence Alignment and Database Searching
Practical Aspects of Multiple Sequence Alignment
Phylogenetic Analysis
Predictive Methods Using Nucleotide Sequences
Predictive Methods Using Protein Sequences
Of Mice and Men: Navigating Public Physical Mapping Databases
ACEDB: A Database for Genome Information
Submitting DNA Sequences to the Databases
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