Biochemistry of Cardiovascular Dysfunction in Obesity 1st edition by Paramjit Tappia, Sukhwinder Bhullar, Naranjan Dhalla ISBN 3030473384 978-3030473389

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ISBN 10: 3030473384 
ISBN 13: 978-3030473389
Author: Paramjit Tappia, Sukhwinder Bhullar, Naranjan Dhalla 

Obesity is an independent risk factor for cardiovascular disease (CVD) in adults as well as in obese children. This book will provide a description of the impact of obesity on the cardiovascular system and increased predisposition to CVD. It will identify the major biochemical mechanisms that lead to the occurrence of myocardial abnormalities and vascular alterations in obesity. We will also have some discussion on the biochemistry of the so-called obesity paradox in relation to CVD. The contributors to this book are international experts on obesity and associated cardiovascular complications. This book is also uniquely positioned as it focuses on the biochemistry of obesity-induced cardiovascular dysfunction. There are 20 chapters in 2 different parts in this book, comprising of Part A: Pathophysiology of Cardiovascular Complications in Obesity (11 chapters) and Part B: Modification of Cardiovascular Dysfunction in obesity (9 chapters). Theintent of this volume is to provide current and basic understanding of the biochemical mechanisms of obesity induced cardiovascular dysfunction that will be of value not only to cardiologists and other allied health professionals, but will also stimulate and motivate biomedical researchers and scientists to find the way to prevent the epidemic of obesity associated cardiovascular abnormalities. Furthermore, this book will serve as a highly useful resource for medical students, fellows, residents and graduate students with an interest in the cardiovascular system.
In summary, this book covers a broad range of biochemical mechanisms of obesity-induced cardiovascular complications. We hope that the reader will understand that obesity is linked to an increase in the risk and occurrence of fatal CVD. Furthermore, the underlying message presented in the book is that the cause of obesity related disorders is complex and that understanding the biochemistry of cardiovascular dysfunction may contribute to the development of novel interventions for the prevention and treatment of obesity associated comorbidities.

Biochemistry of Cardiovascular Dysfunction in Obesity 1st Table of contents:

Part I: Introduction to Obesity and Cardiovascular Dysfunction

1. Overview of Obesity and Its Impact on Health
   • Definition and Classification of Obesity
   • Global Prevalence and Trends in Obesity
   • Obesity as a Risk Factor for Cardiovascular Disease
2. Pathophysiology of Cardiovascular Dysfunction
   • Basic Cardiovascular Physiology
   • Mechanisms of Cardiovascular Dysfunction in Obesity
   • Interaction Between Obesity and Cardiovascular Health

Part II: Biochemical Mechanisms Linking Obesity and Cardiovascular Dysfunction

3. Adipose Tissue and Its Role in Obesity
   • Function and Types of Adipose Tissue
   • Adipokines and Their Impact on Cardiovascular Health
   • Chronic Inflammation and Obesity
4. Metabolic Dysfunction and Cardiovascular Risk
   • Insulin Resistance and Hyperglycemia
   • Dyslipidemia in Obesity and Its Cardiovascular Impact
   • The Role of Mitochondrial Dysfunction in Cardiovascular Disease
5. Oxidative Stress and Inflammation in Obesity-Induced Cardiovascular Dysfunction
   • Mechanisms of Oxidative Stress in Obesity
   • Inflammatory Pathways and Cytokine Involvement
   • Impact of Oxidative Stress on the Endothelium and Vasculature

Part III: Molecular and Cellular Pathways Involved in Obesity-Related Cardiovascular Dysfunction

6. Endothelial Dysfunction in Obesity
   • Mechanisms of Endothelial Dysfunction
   • Role of Nitric Oxide and Vascular Reactivity
   • Implications for Atherosclerosis and Hypertension
7. The Renin-Angiotensin-Aldosterone System (RAAS) in Obesity
   • Activation of RAAS in Obesity and Cardiovascular Disease
   • Role of Angiotensin II in Vascular Remodeling
   • Impact of RAAS Blockade on Cardiovascular Dysfunction
8. Adiposity and the Sympathetic Nervous System
   • Interaction Between Obesity and Sympathetic Nervous System Activation
   • Effect on Blood Pressure and Cardiac Function
   • Central Nervous System Control of Cardiovascular Regulation in Obesity

Part IV: Cardiovascular Manifestations of Obesity

9. Obesity-Induced Hypertension
   • Mechanisms of Obesity-Related Hypertension
   • Role of Adipokines, Insulin Resistance, and Sympathetic Activity
   • Treatment and Management of Obesity-Related Hypertension
10. Obesity and Atherosclerosis
    • Pathophysiology of Atherosclerosis in Obesity
    • Impact of Dyslipidemia and Inflammation on Plaque Formation
    • Risk Factors for Coronary Artery Disease in Obese Individuals
11. Obesity and Heart Failure
    • Mechanisms Leading to Heart Failure in Obesity
    • Obesity-Related Cardiac Remodeling and Diastolic Dysfunction
    • Obesity Paradox: Outcomes in Obese Heart Failure Patients

Part V: Biomarkers and Diagnostics

12. Biomarkers of Cardiovascular Dysfunction in Obesity
    • Circulating Adipokines and Cardiovascular Risk Markers
    • Metabolomics and Lipid Profiling in Obesity-Related Cardiovascular Disease
    • Emerging Biomarkers for Early Detection
13. Diagnostic Approaches in Obesity-Related Cardiovascular Disease
    • Imaging Techniques for Cardiovascular Assessment
    • Blood Pressure and Lipid Profiling
    • Role of Genetic and Epigenetic Markers in Disease Diagnosis

Part VI: Therapeutic Approaches and Future Directions

14. Lifestyle Modifications and Cardiovascular Health
    • Impact of Diet and Physical Activity on Obesity and Cardiovascular Disease
    • Weight Loss Interventions and Their Cardiovascular Benefits
    • Behavioral and Psychological Approaches to Managing Obesity
15. Pharmacological Treatments for Obesity and Cardiovascular Dysfunction
    • Anti-obesity Medications and Their Cardiovascular Effects
    • Statins, ACE Inhibitors, and Other Cardiovascular Drugs
    • Emerging Therapies for Obesity-Related Cardiovascular Disease
16. Surgical Interventions and Cardiovascular Outcomes
    • Bariatric Surgery and Its Impact on Cardiovascular Function
    • Mechanisms of Cardiovascular Benefit Following Weight Loss Surgery
    • Long-Term Outcomes and Risks

Part VII: Prevention and Public Health Implications

17. Public Health Approaches to Obesity Prevention
    • Strategies for Obesity Prevention at the Population Level
    • Policy Approaches and Nutritional Guidelines
    • The Role of Healthcare Providers in Obesity Management
18. The Future of Cardiovascular Health in Obesity
    • Advances in Genetic and Precision Medicine
    • Integrating Omics Technologies in Obesity and Cardiovascular Research
    • The Role of Artificial Intelligence and Big Data in Obesity-Related Cardiovascular Disease Management

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