Biochemistry Concepts and Connections 1st Edition by Dean R Appling, Spencer J Anthony Cahill, Christopher K Mathews ISBN 9781292112008

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ISBN 10: 
ISBN 13: 9781292112008
Author: Dean R Appling, Spencer J Anthony Cahill, Christopher K Mathews

A highly visual, precise and fresh approach to guide today’s mixed-science majors to a deeper understanding of Concepts and Connections engages students in the rapidly evolving field of biochemistry, better preparing them for the challenges of 21st century science through quantitative reasoning skills and a rich, chemical perspective on biological processes.

This concise first edition teaches mixed-science-majors the chemical logic underlying the mechanisms, pathways, and processes in living cells through groundbreaking biochemical art and a clear narrative that illustrates biochemistry’s relation to all other life sciences. Integration of biochemistry’s experimental underpinnings alongside the presentation of modern techniques encourages students to appreciate and consider how their understanding of biochemistry can and will contribute to solving problems in medicine, agricultural sciences, environmental sciences, and forensics.

Biochemistry Concepts and Connections 1st Table of contents:

Part 1: Introduction to Biochemistry

1. The Chemical Basis of Life

   • Elements of Life
   • Atomic Structure and Chemical Bonds
   • Water and pH
   • Functional Groups and Organic Molecules
   • The Importance of Carbon

2. Biological Macromolecules

   • Proteins: Structure and Function
   • Nucleic Acids: DNA and RNA
   • Carbohydrates: Monosaccharides, Disaccharides, and Polysaccharides
   • Lipids: Fatty Acids, Membranes, and Steroids

Part 2: The Molecular Basis of Life 3. Enzyme Structure and Function

• Enzyme Kinetics
• Enzyme Regulation
• Enzyme Inhibition
• Coenzymes and Cofactors

4. Metabolism and Thermodynamics
   • Principles of Thermodynamics
   • Energy Changes in Biochemical Reactions
   • The Role of ATP in Cellular Metabolism
   • Metabolic Pathways and Regulation

Part 3: Bioenergetics and Metabolic Pathways 5. Carbohydrate Metabolism

• Glycolysis
• The Citric Acid Cycle
• Glycogen Metabolism and Gluconeogenesis
• The Pentose Phosphate Pathway

6. Fatty Acid Metabolism

   • Fatty Acid Synthesis and Degradation
   • Ketone Body Formation
   • Lipoprotein Metabolism

7. Protein and Amino Acid Metabolism

   • Amino Acid Catabolism
   • Urea Cycle
   • Protein Synthesis and Degradation
   • Amino Acids and Metabolic Regulation

8. Nucleic Acid Metabolism

   • Purine and Pyrimidine Metabolism
   • Nucleotide Synthesis and Degradation
   • DNA Repair Mechanisms

Part 4: Molecular Genetics 9. DNA Structure and Function

• The Double Helix and Chromatin Structure
• DNA Replication
• RNA Transcription

10. Gene Expression and Regulation

    • The Genetic Code
    • Translation and Protein Synthesis
    • Gene Regulation in Prokaryotes and Eukaryotes
    • Post-transcriptional Modifications

11. Genomics and Proteomics

    • The Human Genome
    • Genomic Sequencing Techniques
    • Proteomics and Protein Analysis

Part 5: Biochemical Signaling 12. Cellular Signaling and Communication – Signal Transduction Pathways – Second Messengers – G-Protein Coupled Receptors – Kinase Cascades and Cell Cycle Regulation

Part 6: Biochemistry in Health and Disease 13. Biochemistry of Cancer – Oncogenes and Tumor Suppressor Genes – Metabolic Changes in Cancer Cells – Cancer Therapies and Targeted Drugs

14. Biochemical Basis of Disease
    • Genetic Disorders: Enzyme Deficiencies
    • Metabolic Diseases and Disorders
    • The Role of Biochemistry in Medical Diagnostics

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