Bioassays in Experimental and Preclinical Pharmacology 1st edition by Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan ISBN‎ 1071612352 978-1071612354

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ISBN 10: 1071612352
ISBN 13: 978-1071612354
Author: Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan

This detailed book explores protocols for a wide array of preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research. Written for the Springer Protocols Handbooks series, the methodologies included in this collection have been standardized by the authors through extensive use in the lab so that they are ready to be applied in the labs of readers around the world.
Authoritative and practical, Bioassays in Experimental and Preclinical Pharmacology aims to assist undergraduate and postgraduate students, research scholars, scientists, and other academicians performing research in the vital field of drug discovery.

Bioassays in Experimental and Preclinical Pharmacology 1st Table of contents:

• Introduction to Bioassays: The book provides foundational knowledge about bioassays, which are laboratory tests that measure the effects of substances (such as drugs, chemicals, or biological agents) on living organisms or cells. These tests help in understanding how substances interact with biological systems.

• Experimental Pharmacology: It delves into the use of bioassays in the experimental setting, discussing their importance in understanding mechanisms of action, dose-response relationships, and the pharmacodynamics of drug candidates.

• Preclinical Pharmacology: The book addresses the preclinical phase of drug development, where bioassays are essential for assessing the pharmacokinetics, toxicity, and safety profiles of new compounds before advancing to human clinical trials.

• Assay Techniques: Various bioassay techniques are covered, such as receptor binding assays, enzyme inhibition assays, cell-based assays, and animal model-based assays, among others. The book also explores how these techniques can be adapted or refined to meet specific research objectives.

• Regulatory Guidelines and Standards: The authors emphasize the importance of adhering to regulatory requirements when designing and conducting bioassays, ensuring that data collected during the preclinical phase is reliable, reproducible, and compliant with international standards.

• Emerging Technologies: The text may also touch upon new advancements and technologies in bioassay development, including automation, high-throughput screening, and the integration of bioinformatics tools to enhance the efficiency and precision of bioassays in drug discovery.

• Applications in Drug Discovery and Development: The book provides real-world applications of bioassays in identifying and validating new drug targets, optimizing drug formulations, and advancing compounds through the preclinical stages.

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