Bayesian Phylogenetic Inference under a Statistical Insertion Deletion Model 1st Edition by Gerton Lunter, István Miklós, Alexei Drummond, Jens Ledet Jensen, Jotun Hein 9783540200765

Bayesian Phylogenetic Inference under a Statistical Insertion Deletion Model 1st Edition by Gerton Lunter, István Miklós, Alexei Drummond, Jens Ledet Jensen, Jotun Hein – Ebook PDF Instant Download/Delivery. 9783540200765

Full download Bayesian Phylogenetic Inference under a Statistical Insertion Deletion Model 1st Edition after payment

Product details:

ISBN 13: 9783540200765

Author: Gerton Lunter, István Miklós, Alexei Drummond, Jens Ledet Jensen; Jotun Hein

A central problem in computational biology is the inference of phylogeny given a set of DNA or protein sequences. Currently, this problem is tackled stepwise, with phylogenetic reconstruction dependent on an initial multiple sequence alignment step. However these two steps are fundamentally interdependent. Whether the main interest is in sequence alignment or phylogeny, a major goal of computational biology is the co-estimation of both. Here we present a first step towards this goal by developing an extension of the Felsenstein peeling algorithm. Given an alignment, our extension analytically integrates out both substitution and insertion–deletion events within a proper statistical model. This new algorithm provides a solution to two important problems in computational biology. Firstly, indel events become informative for phylogenetic reconstruction, and secondly phylogenetic uncertainty can be included in the estimation of insertion-deletion parameters. We illustrate the practicality of this algorithm within a Bayesian Markov chain Monte Carlo framework by demonstrating it on a non-trivial analysis of a multiple alignment of ten globin protein sequences.

Bayesian Phylogenetic Inference under a Statistical Insertion Deletion Model 1st Table of contents:

1 Introduction

2 The TKF model

3 Computing the likelihood of a homology structure

4 Results

5 Discussion

People also search for Bayesian Phylogenetic Inference under a Statistical Insertion Deletion Model 1st: 

o bayes 2022

phylogenetic inference

quantum bayesian network

q yin uc davis