Apoptosis Senescence and Cancer 2nd Edition by David Gewirtz, Shawn Holt, Steven Grant ISBN 9781597452212 159745221X

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Product details:
ISBN 10: 159745221X 
ISBN 13: 9781597452212 
Author: David Gewirtz, Shawn Holt, Steven Grant

Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers.

The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death, followed by chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third part covers DNA Damage Response, Signaling Pathways and Tumorigenesis, while the fourth delves into Resistance and Sensitization. The book concludes with Established Cancer Therapies and a section which looks toward the future with Recent and Developing Cancer Therapies.

In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.

Apoptosis Senescence and Cancer 2nd Edition Table of contents:

1. Introduction to Apoptosis, Senescence, and Cancer

• Overview of Apoptosis and Senescence
• The Role of Cell Death in Cancer Development
• Molecular Pathways of Apoptosis and Senescence
• Importance of Understanding Cell Death in Cancer Therapy

2. Mechanisms of Apoptosis

• The Extrinsic Pathway of Apoptosis
• The Intrinsic Pathway of Apoptosis
• Mitochondrial Regulation of Apoptosis
• Caspases and the Execution Phase of Apoptosis
• Regulation of Apoptotic Signaling

3. Senescence and Its Role in Cancer

• Cellular Senescence: Definition and Mechanisms
• Senescence-Inducing Stress and Pathways
• Senescence in Tumor Suppression
• The Paradox of Senescence in Cancer Progression
• Senescence and the Tumor Microenvironment

4. Apoptotic Pathways and Cancer

• Dysregulation of Apoptosis in Cancer Cells
• Oncogenes and Tumor Suppressor Genes in Apoptosis Regulation
• Mitochondrial Dysfunction and Cancer Cell Survival
• Resistance to Apoptosis in Cancer Therapy
• Targeting Apoptotic Pathways in Cancer Treatment

5. Senescence and Cancer: The Tumor Suppression Paradigm

• Senescence as a Barrier to Tumorigenesis
• The Role of p53, p16INK4a, and Other Tumor Suppressors in Senescence
• The Senescence-Associated Secretory Phenotype (SASP)
• Impact of Senescence on Tumor Microenvironment and Therapy
• Therapeutic Implications of Senescence in Cancer

6. Apoptosis and Chemotherapy

• Chemotherapeutic Agents That Induce Apoptosis
• Mechanisms of Drug Resistance in Apoptotic Pathways
• Sensitizing Cancer Cells to Chemotherapy via Apoptosis
• Targeting Apoptotic Regulators to Overcome Resistance
• Clinical Implications and Future Strategies in Chemotherapy

7. Senescence and Cancer Therapy

• Senescence-Inducing Drugs and Their Potential
• The Role of Senescence in Chemotherapy Resistance
• Therapeutic Strategies Targeting Senescence Pathways
• Combination Therapies Involving Senescence Modulation
• Translational Potential and Clinical Trials in Senescence-Based Therapy

8. The Tumor Microenvironment: Apoptosis, Senescence, and Cancer Progression

• The Microenvironment’s Influence on Apoptosis and Senescence
• Cancer-Associated Fibroblasts and Immune Cells in Apoptosis/Senescence
• Interactions Between Senescent Cells and the Tumor Microenvironment
• Apoptosis and Senescence in Tumor-Host Interactions

9. Targeting Apoptosis and Senescence in Cancer Therapy

• Small Molecule Inhibitors and Activators of Apoptosis Pathways
• Gene Therapy Approaches to Modulate Apoptosis and Senescence
• Nanotechnology in Targeting Apoptosis and Senescence
• Immunotherapies and Their Effect on Apoptosis/Senescence Pathways

10. Advances in Cancer Therapies Targeting Apoptosis and Senescence

• Current Status of Apoptosis-Based and Senescence-Based Therapies
• Personalized Medicine Approaches in Cancer Treatment
• Drug Development and Screening for Apoptosis and Senescence Modulators
• Clinical Challenges and Opportunities in Cancer Therapy

11. Future Directions in Apoptosis, Senescence, and Cancer Research

• New Insights into Apoptotic and Senescence Pathways
• Emerging Technologies for Studying Cell Death and Senescence
• The Promise of Combination Therapies Targeting Multiple Pathways
• Clinical Trials and Translational Research
• The Future of Apoptosis and Senescence in Cancer Treatment

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