Antigen Presenting Cells From Mechanisms to Drug Development 1st Edition by Harald Kropshofer, Anne Vogt ISBN 3527311084 9783527311088
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Authors:Harald Kropshofer; Anne B. Vogt , Series:Microbiology [14] , Tags:Science; Life Sciences; Cell Biology; Biology; Microbiology; 352760698X.pdf , Author sort:Kropshofer, Harald & Vogt, Anne B. , Ids:9783527606986 , Languages:Languages:eng , Published:Published:May 2006 , Publisher:John Wiley & Sons , Comments:Comments:This novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our innate and adaptive immune system. Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist, immunologist, and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providing the latest immunological facts with a focus on drug development. Backed by a glossary explaining all important technical terms, this short but comprehensive reference covers basic introductory aspects right up to details for advanced specialists.
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ISBN 10: 3527311084
ISBN 13: 9783527311088
Author: Harald Kropshofer, Anne Vogt
Antigen Presenting Cells From Mechanisms to Drug Development 1st Edition Table of contents:
1. Introduction to Antigen Presenting Cells (APCs)
- Overview of the Immune System
- Function and Importance of Antigen-Presenting Cells
- Types of Antigen Presenting Cells: Dendritic Cells, Macrophages, and B Cells
- General Mechanisms of Antigen Presentation
2. The Molecular Mechanisms of Antigen Presentation
- Antigen Uptake and Processing
- MHC Molecules and Antigen Recognition
- Cross-Presentation and Its Role in Immune Activation
- Co-stimulatory Molecules and Their Significance
- The Role of Cytokines in APC Function
3. Dendritic Cells and Their Role in Immunity
- Characteristics of Dendritic Cells
- The Development and Differentiation of Dendritic Cells
- Dendritic Cell Migration and Activation
- Dendritic Cells in T Cell Priming and Tolerance
4. Macrophages as Antigen Presenting Cells
- Macrophage Differentiation and Activation
- Macrophage Role in Antigen Processing and Presentation
- Macrophages in Inflammation and Immune Defense
- Macrophages in Tolerance and Immunosuppression
5. B Cells as Antigen Presenting Cells
- B Cell Receptors and Antigen Recognition
- B Cell Activation and Interaction with T Cells
- B Cells in Antibody Production and Immune Memory
- B Cells in Autoimmune Diseases
6. Regulation of Antigen Presentation and Immune Responses
- Negative Regulation of Antigen Presentation
- Immune Tolerance and Immune Suppression Mechanisms
- Role of Regulatory T Cells (Tregs) in Modulating APC Function
- Immunological Memory and the Role of APCs
7. APCs and the Immune Response in Disease
- APCs in Infectious Diseases
- APCs in Autoimmune Diseases
- APCs in Cancer Immunotherapy
- APCs in Allergic Reactions and Chronic Inflammation
8. Therapeutic Targeting of Antigen Presenting Cells
- Strategies for Modulating APC Function
- Immunotherapeutic Approaches Targeting APCs
- Vaccination and APC Activation
- Development of Drugs Targeting APCs for Autoimmune Diseases
9. Advances in APC-Based Drug Development
- Targeting APCs in Cancer Immunotherapy
- Adjuvants and APC Modulation in Vaccine Design
- Nanoparticles and APC-Specific Drug Delivery
- Clinical Trials Involving APC-Based Therapies
10. Future Directions in APC Research and Drug Development
- Emerging Insights in APC Biology
- New Approaches in Immunomodulation and Drug Development
- Challenges and Opportunities in Translating APC Research to Therapeutics
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