A phatmacology Primer 6th Edition by Terry Kenakin ISBN 0323992897 9780323992893

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ISBN 10: 0323992897
ISBN 13: 9780323992893
Author: Terry Kenakin

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Sixth Edition features the latest research surrounding the application of pharmacology in drug discovery in an effort to equip readers with a deeper understanding of complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for anyone involved in drug discovery. This edition has been reorganized for better flow and clarity and includes material on new technologies for screening (virtual, DNA encoded libraires, fragment-based) and a major section on phenotypic (target agnostic) screening for new leads and determination of drug targets.

With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.

• Highlights changes surrounding the strategy of drug discovery, providing a comprehensive reference with advances in the methods involved in lead optimization and more effective drug discovery
• Includes multiple new sections on screening, phenotypic (target agnostic) screening for new leads, and determination of new drug targets
• Illustrates the application of rapid, inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
• Includes test questions and answers

A phatmacology Primer 6th Edition Table of contents:

Part 1: Foundations of Pharmacology

1. Introduction to Pharmacology: History and Basic Concepts
2. Drug-Receptor Theory: Binding and Activation
3. Pharmacokinetics: The Movement of Drugs in the Body
4. Pharmacodynamics: Mechanisms of Drug Action

Part 2: Principles of Drug Action
5. Receptor Types and Signal Transduction Pathways
6. Agonists and Antagonists: Dose-Response Relationships
7. Allosteric Modulation: Expanding Drug Action Mechanisms
8. Drug Efficacy and Potency: Key Concepts and Calculations

Part 3: Experimental Pharmacology
9. Designing and Interpreting Pharmacological Experiments
10. Methods for Measuring Drug Effects: In Vitro and In Vivo Techniques
11. Assay Systems: Biochemical and Cellular Approaches
12. Quantitative Analysis of Drug-Receptor Interactions

Part 4: Advanced Topics in Pharmacology
13. Biased Signaling: Functional Selectivity of Drugs
14. Pharmacogenomics: Personalized Medicine and Genetic Variability
15. Advances in Drug Discovery and Development

Part 5: Practical Applications
16. Translating Pharmacology into Clinical Practice
17. Understanding and Avoiding Adverse Drug Reactions
18. Integrating Pharmacological Data for Decision-Making

Part 6: Case Studies and Applications
19. Case Studies in Receptor Pharmacology
20. Applying Pharmacological Principles to Real-World Scenarios

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