Molecular Pathology in Cancer Research 1st edition by Sunil Lakhani, Stephen Fox ISBN 1493982583 978-1493982585

• Overview of molecular pathology and its role in cancer research
• The evolution of cancer biology
• Basic genetic and epigenetic mechanisms in cancer

2. Molecular Basis of Cancer

• Oncogenes and tumor suppressor genes
• Signal transduction pathways in cancer
• Cancer stem cells and their role in tumorigenesis

3. Genetic Alterations in Cancer

• Mutations, amplifications, and deletions in cancer cells
• Chromosomal instability and translocations
• Gene expression profiling in cancer

4. Epigenetics in Cancer

• DNA methylation and histone modification
• Epigenetic silencing of tumor suppressor genes
• The role of non-coding RNAs (e.g., microRNAs) in cancer

5. Cancer Genomics and Bioinformatics

• Next-generation sequencing (NGS) in cancer research
• Computational approaches in analyzing cancer genomics data
• Cancer databases and bioinformatics tools

6. Molecular Diagnostics in Cancer

• Diagnostic applications of molecular pathology
• Biomarkers for early detection and prognosis
• Liquid biopsy and circulating tumor DNA (ctDNA)

7. Molecular Pathology of Specific Cancers

• Molecular mechanisms of common cancers (e.g., lung, breast, colon, and prostate cancer)
• Cancer heterogeneity and subtypes
• Personalized medicine and targeted therapies

8. Translational Applications of Molecular Pathology

• The clinical impact of molecular diagnostics
• Companion diagnostics and targeted therapies
• Challenges in implementing molecular pathology in clinical practice

9. Emerging Technologies in Cancer Research

• CRISPR and gene editing in cancer therapy
• Single-cell RNA sequencing and its applications
• Advances in proteomics and metabolomics

10. Future Directions in Molecular Pathology of Cancer

• The potential of immunotherapy and molecular-targeted drugs
• Advances in cancer vaccines and gene therapies
• The future of personalized and precision medicine in cancer treatment