Pathology and Epidemiology of Cancer Molecular Underpinnings 1st edition by Massimo Loda, Lorelei Mucci, Megan Mittelstadt, Mieke Van Hemelrijck, Maura Bríd Cotter Pathology & Epidemiology of Cancer: Molecular Underpinnings 1st edition by Massimo Loda, Lorelei Mucci, Megan Mittelstadt ISBN 3319351516 978-3319351513

Pathology & Epidemiology of Cancer: Molecular Underpinnings 1st edition by Massimo Loda, Lorelei Mucci, Megan Mittelstadt, Mieke Van Hemelrijck, Maura Bríd Cotter Pathology & Epidemiology of Cancer: Molecular Underpinnings 1st edition by Massimo Loda, Lorelei Mucci, Megan Mittelstadt – Ebook PDF Instant Download/Delivery. 3319351516 978-3319351513
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Product details:

ISBN 10: 3319351516 
ISBN 13: 978-3319351513
Author: Massimo Loda, Lorelei Mucci, Megan Mittelstadt 

This book integrates the disciplines of cancer pathology and epidemiology to provide a synergistic and complementary approach to understanding the molecular mechanisms of cancer. This book provides relevant information on the diagnostic, prognostic and predictive molecular pathology of cancer.  Epidemiological studies, including descriptive epidemiology, risk factors and molecular mechanisms of disease inform on the etiology and progression of cancer. The text concentrates on major cancers that are currently prevalent and those for which substantial molecular, pathological and epidemiological data is available. Each section is designed to provide an overview of that cancer type in terms of basic biology, review the current epidemiological data surrounding that cancer type and provide information on common practices and challenges related to the molecular pathology of that cancer type. Several relevant techniques in molecular pathology, which facilitate diagnosis and treatment are also explored.  
Pathology and Epidemiology of Cancer provides a succinct and comprehensive overview of multiple cancer types to guide clinicians during patient care and to guide scientists for innovations in research. It represents an integral resource for pathologists, epidemiologists, medical students as well as translational, basic and clinical science researchers who are all working to progress the field of cancer in terms of diagnosis, treatment and prevention.

Pathology & Epidemiology of Cancer: Molecular Underpinnings 1st Table of contents:

1. Introduction to Cancer Pathology and Epidemiology

   • Overview of cancer as a disease.
   • Historical development in the study of cancer.
   • The role of pathology and epidemiology in cancer research.

2. Molecular Basis of Cancer

   • Cancer cell biology: mutations, oncogenes, tumor suppressor genes.
   • The role of DNA repair mechanisms and genomic instability.
   • Epigenetics and cancer: how environmental factors influence gene expression.

3. Cancer Development and Progression

   • The process of carcinogenesis: initiation, promotion, and progression.
   • The hallmarks of cancer (e.g., evasion of apoptosis, sustained proliferative signaling).
   • The tumor microenvironment and cancer stem cells.

4. Genetic and Environmental Factors in Cancer

   • Genetic predispositions: inherited mutations and syndromes.
   • Environmental exposures: tobacco, radiation, diet, and infectious agents.
   • The interaction between genetics and environment in cancer risk.

5. Molecular Epidemiology of Cancer

   • Techniques in molecular epidemiology.
   • Cancer risk factors and biomarkers.
   • Population-based studies and global cancer incidence patterns.

6. Cancer Pathology: Diagnosis and Classification

   • Histological and molecular diagnostic techniques.
   • The role of pathology in cancer staging and grading.
   • Immunohistochemistry and molecular profiling in cancer diagnosis.

7. Cancer Epidemiology: Patterns and Prevention

   • Cancer incidence, mortality, and survival trends.
   • Prevention strategies: screening, vaccination, and lifestyle changes.
   • The role of public health policies and interventions.

8. Targeted Therapies and Cancer Treatment

   • Molecular targets in cancer therapy.
   • Chemotherapy, radiotherapy, and immunotherapy.
   • The role of precision medicine and personalized cancer treatments.

9. Cancer Metastasis

   • The biology of metastasis: steps in the spread of cancer.
   • Molecular mechanisms that drive metastasis.
   • The role of the immune system in metastasis.

10. Cancer Immunology and Immunotherapy

    • Tumor immunology: how cancers evade the immune system.
    • Immune checkpoint inhibitors and cancer immunotherapies.
    • Advances in cancer vaccines and adoptive T-cell therapies.

11. Emerging Technologies in Cancer Research

    • Next-generation sequencing and its role in cancer genomics.
    • Liquid biopsies and biomarkers for early detection.
    • Advances in imaging and other diagnostic technologies.

12. Future Directions in Cancer Research and Epidemiology

    • Ongoing challenges in cancer prevention, detection, and treatment.
    • The promise of artificial intelligence and big data in cancer research.
    • The future of personalized cancer medicine.

Appendices:

• Glossary of terms related to cancer pathology and epidemiology.
• Index of key topics and references for further reading.

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