The Serotonin System History Neuropharmacology and Pathology 1st editon by Mark Tricklebank, Eileen Daly ISBN 0128133236 978-0128133231

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ISBN 10: 0128133236
ISBN 13: 978-0128133231
Author: Mark Tricklebank, Eileen Daly 

The Serotonin System: History, Neuropharmacology, and Pathology provides an up-to-date accounting on the physiology and pathophysiology of serotonin and the role it plays in behavioral functions. In addition, the book explores the potential roles of 5-HT1 in neurodevelopmental disorders and summarizes the history of the discovery and development of serotonergic drugs for the treatment of neuropsychiatric disorders. This concise, yet thorough, volume is the perfect introduction to this critical neurotransmitter. It is ideal for students and researchers new to the study of behavior, neuropsychiatry or neuropharmacology, but is also a great resource for established investigators who want a greater perspective on serotonin.

• Examines the role of serotonin in physiological functions and neuropsychiatric disorders
• Provides in-depth knowledge on all aspects of the serotonin system
• Explores serotonergic receptors as targets for both current and new therapeutic compounds

The Serotonin System: History, Neuropharmacology, and Pathology 1st Table of contents:

• Introduction to the Serotonin System

  • Overview of serotonin (5-HT) as a neurotransmitter.
  • Discovery and historical context of serotonin’s role in the brain and body.
  • The role of serotonin in mental and physical health.

• Chemistry and Biology of Serotonin

  • Synthesis and metabolism of serotonin.
  • Serotonin receptors: types, functions, and distribution in the body.
  • Serotonin transporters and their role in neurotransmission.

• Neuropharmacology of Serotonin

  • Pharmacodynamics of serotonin and its receptors.
  • Drugs that modulate serotonin activity: SSRIs, SNRIs, and other serotonergic agents.
  • The therapeutic uses of serotonergic drugs in psychiatry and neurology.

• Serotonin Pathways in the Brain

  • Overview of serotoninergic pathways and their functions.
  • Brain regions involved in serotonergic transmission (e.g., the raphe nuclei, prefrontal cortex).
  • The role of serotonin in mood regulation, cognition, and behavior.

• The Role of Serotonin in Mental Health

  • Serotonin and its involvement in mood disorders: depression, anxiety, and bipolar disorder.
  • The serotonin hypothesis of depression and alternative theories.
  • Serotonergic dysfunction in schizophrenia, PTSD, and other psychiatric conditions.

• Serotonin and Neurological Disorders

  • The role of serotonin in neurological diseases such as Parkinson’s disease and Alzheimer’s disease.
  • Serotonin in migraine and headache disorders.
  • Serotonergic involvement in neurodegeneration and other pathologies.

• Serotonin and the Gut-Brain Axis

  • The role of serotonin in gastrointestinal function and gut-brain communication.
  • Serotonin’s influence on the enteric nervous system and its implications for gastrointestinal disorders.

• Pathology of Serotonergic Dysfunction

  • Disorders associated with serotonin dysregulation: serotonin syndrome, carcinoid syndrome.
  • Neurodegenerative diseases linked to serotonin pathology.
  • Serotonin’s role in addiction, eating disorders, and sleep disorders.

• Serotonin and the Immune System

  • The interaction between serotonin and immune function.
  • Serotonergic modulation in inflammation and immune response.

• Therapeutic Implications and Future Directions

  • Advances in serotonergic drug therapies and their future potential.
  • Experimental treatments targeting the serotonin system.
  • Challenges and controversies in serotonin research and therapy.

• Conclusion

  • Summary of serotonin’s impact on brain function, behavior, and health.
  • Future research directions in serotonin neuropharmacology and pathology.

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