Practical Surgical Pathology of the Breast 1st editon by Juan Palazzo ISBN 1620701057 978-1620701058

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ISBN 10: 1620701057 
ISBN 13:  978-1620701058
Author: Juan Palazzo 

Practical Surgical Pathology of the Breast is a comprehensive and accessible guide for the practicing pathologist and trainee. It provides anatomic pathologists with the essential knowledge and tools to navigate breast cases and classification systems that are commonly and uncommonly found in everyday practice. Particularly challenging topics such as understanding the molecular mechanisms linked to breast cancer and the interpretation of molecular tests, are covered in clear prose, along with useful discussions on diagnostic challenges written by world experts. The use of immunohistochemistry in breast pathology is discussed in detail and how to apply it to resolve diagnostic problems. As a result, the book simplifies difficult-to-master issues such as recognizing therapy-induced changes to breast specimens and identifying borderline breast lesions and many more.

Each chapter features high-quality images and stains, tables that emphasize differential diagnoses, text that highlight common diagnostic pitfalls with corresponding tips, as well as helpful key points and how to reach an accurate diagnosis using appropriate procedures and tests. With Practical Surgical Pathology of the Breast as a guide, practitioners and residents can hone their diagnostic skills, resolve difficult cases and improve their approach to breast cases in their daily practice.

Practical Surgical Pathology of the Breast 1st Table of contents:

• Introduction to Breast Pathology

  • Overview of the anatomy and physiology of the breast.
  • Principles of breast pathology.
  • Basic diagnostic approaches: clinical, radiological, and histopathological.

• Normal Breast Development and Histology

  • The stages of normal breast development.
  • Histological structure of normal breast tissue.
  • Hormonal influences on the breast.

• Benign Breast Lesions

  • Fibrocystic changes and cysts.
  • Fibroadenoma and other benign epithelial proliferations.
  • Benign lesions of the breast: papillomas, phyllodes tumors, and lipomas.
  • Inflammatory conditions of the breast: mastitis and abscesses.

• Premalignant Lesions of the Breast

  • Epithelial hyperplasia and atypical hyperplasia.
  • Ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS).
  • Risk factors and prognostic implications.

• Breast Carcinoma

  • Invasive ductal carcinoma (IDC): histopathological features, grading, and staging.
  • Invasive lobular carcinoma (ILC): characteristics and diagnosis.
  • Other invasive carcinomas: medullary carcinoma, mucinous carcinoma, inflammatory carcinoma.
  • Prognostic markers in breast cancer: hormone receptors, HER2, and genetic mutations.

• Molecular Pathology of Breast Cancer

  • Genetic mutations in breast cancer: BRCA1, BRCA2, and other susceptibility genes.
  • Molecular subtypes of breast cancer.
  • Advances in molecular diagnostic techniques.

• Lymphatic and Vascular Involvement in Breast Cancer

  • Lymph node metastasis: significance and pathology.
  • Vascular invasion and its role in metastasis.
  • Staging of breast cancer based on lymph node involvement.

• Diagnostic Techniques in Breast Pathology

  • Core needle biopsy and fine needle aspiration (FNA).
  • Role of immunohistochemistry in breast pathology.
  • Molecular techniques: FISH, PCR, and microarray analysis.

• Breast Cancer Prognosis and Therapy

  • Histologic grading and staging systems.
  • Pathological evaluation of surgical margins.
  • Chemotherapy, radiotherapy, and targeted therapy.
  • Role of sentinel lymph node biopsy.

• Special Topics in Breast Pathology

  • Male breast pathology.
  • Pathology of the axillary lymph nodes.
  • Paget’s disease of the breast.
  • Inflammatory breast cancer.

• Case Studies and Clinical Correlations

  • Case-based approach to common and uncommon breast lesions.
  • Differential diagnoses in breast pathology.
  • Integration of clinical and pathological findings.

• Emerging Trends in Breast Pathology

  • Advances in molecular and genetic profiling.
  • The role of artificial intelligence in breast cancer diagnosis.
  • The future of personalized medicine in breast cancer.

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