Mediastinal pathology 1st editon by Neda Kalhor, Cesar Moran ISBN 3319989790 978-3319989792

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ISBN 10:  3319989790
ISBN 13: 978-3319989792
Author: Neda Kalhor, Cesar Moran 

The mediastinum is a hollow space within the thoracic cavity that may give rise to a wide spectrum of tumoral conditions from the benign to the intermediate to the highly malignant neoplasms. In addition, other inflammatory and infectious conditions may also arise in this space, which renders the practice of mediastinal pathology, almost a general surgical pathology practice. However, there are numerous mediastinal conditions that are important not only for diagnosis but also for treatment and clinical outcome. Due to the unusual location and because of the complexity of the tumors occurring in the mediastinum, there are only a few experts in this particular anatomic area. In fact, there are no more than 3-4 individuals worldwide with enough experience to properly diagnose, classify, and make treatment suggestions when these tumors arise in the mediastinum.
More recent developments in tumor diagnosis and classification havecreated a vacuum in the general pathologist who often is confronted with this pathology and becomes uneasy about the specifics. For instance, recent developments in tumor pathology have led to the classification and staging of mediastinal tumors in more innovative ways that are in need of proper highlighting. Needless to say, even though there are a few publications on mediastinal pathology, the books are either obsolete or incomplete, in addition of providing superficial knowledge. Unfortunately and with all due respect to the authors of those publications, neither of those books is written by experts in the area. Rather the books were written out of the lack of information in mediastinal pathology. Even the World Health Organization (WHO) publication, which is truly more on lung and pleural neoplasms, has inserted in its contents a portion of mediastinal tumors, such portion not only is superficial and incomplete but also at least highly controversial ifnot flat out incorrect. .
This text’s goal is to present comprehensive and up to date information of the diverse pathology that can be encountered in the mediastinal compartment. The book will be divided in 11 different chapters based on the lineage of the diverse tumors that occur in the mediastinum, i.e. epithelial, neuroendocrine, lymphoid, etc (see table of contents). In addition, two separate chapters will be included -one on the radiological aspects and the others on the surgical approach to the different mediastinal tumors., bringing a total of 13 chapters. In the pathology section, the book will include current staging and classification systems of the different tumors. In addition, it will address the most current criteria for diagnosis and the differential diagnosis. Although the emphasis of the book is on diagnostic surgical pathology, every chapter will include the use of immunohistochemical techniques, electron microscopy,and molecular biology when necessary. The book will be extensively illustrated so that the reader will benefit of the different histomorphology of mediastinal tumors.
Because of the nature of this specific anatomic area and the need to develop a standard text, Mediastinal Pathology should be of high interest to general surgical pathologists, thoracic pathologists in particular as well as thoracic surgeons, oncologists, and radiologists. Needless to say, this book will be of interest to pathology residents and fellows as well as to those seeking more in depth knowledge of thoracic – mediastinal pathology.

Mediastinal pathology 1st Table of contents:

• Introduction to Mediastinal Pathology

  • Overview of the mediastinum’s anatomy and physiology.
  • Importance of understanding mediastinal diseases for diagnosis and treatment.

• General Approach to Mediastinal Disorders

  • Clinical evaluation and diagnostic methods (e.g., imaging, biopsy, histology).
  • Differential diagnosis of mediastinal masses.
  • Role of radiology and pathology in diagnosing mediastinal conditions.

• Tumors of the Mediastinum

  • Benign Tumors: Thymomas, cysts (e.g., bronchogenic cysts, pericardial cysts).
  • Malignant Tumors: Thymic carcinoma, lymphoma (Hodgkin’s and non-Hodgkin’s), neurogenic tumors, germ cell tumors.
  • Classification, pathology, and clinical implications of mediastinal tumors.
  • Tumor staging, prognosis, and treatment strategies.

• Lymphatic and Vascular Pathology in the Mediastinum

  • Diseases affecting mediastinal lymph nodes, including lymphoma and metastatic disease.
  • Vascular conditions, such as aortic aneurysms and arteriovenous malformations.

• Infectious Diseases of the Mediastinum

  • Mediastinitis: causes (e.g., bacterial, fungal, viral), diagnosis, and treatment.
  • Tuberculosis, fungal infections, and other mediastinal infections.

• Inflammatory and Autoimmune Conditions

  • Sarcoidosis and its effect on the mediastinal lymph nodes.
  • Other inflammatory diseases, including those associated with systemic conditions like rheumatoid arthritis or systemic lupus erythematosus.

• Congenital Anomalies and Developmental Disorders

  • Congenital cysts, bronchogenic cysts, and congenital tumors.
  • Thymic abnormalities and their role in mediastinal pathology.

• Endoscopic and Surgical Approaches to Mediastinal Disease

  • Diagnostic and therapeutic approaches, including mediastinoscopy and thoracoscopy.
  • Surgical management of mediastinal tumors and infections.

• Pathology of the Thymus

  • Thymic hyperplasia, thymomas, and thymic carcinoma.
  • The role of the thymus in autoimmune diseases and its involvement in cancer.

• Mediastinal Pathology in Pediatric and Adult Populations

  • Differences in mediastinal disease between children and adults.
  • Pediatric mediastinal tumors, particularly germ cell tumors.
  • Mediastinal conditions that are more prevalent in adult populations, such as thymoma and lymphoma.

• Case Studies and Clinical Correlations

  • Real-world case studies highlighting the clinical presentation, diagnosis, and management of various mediastinal conditions.
  • The role of pathology in confirming diagnoses and guiding treatment decisions.

• Emerging Trends in Mediastinal Pathology

  • Advances in molecular pathology and genetic testing in diagnosing mediastinal diseases.
  • New therapeutic approaches, including targeted therapies for mediastinal malignancies.

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