Breast Pathology in Clinical Practice 1st edition by Sami Shousha ISBN B08CQCLBBW 978-3030423858

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ISBN 10: B08CQCLBBW 
ISBN 13: 978-3030423858
Author:  Sami Shousha

This book provides a concise, step-by-step guide to accurate microscopic diagnosis for clinicians who deal with patients with breast lesions. The emphasis is on a practical approach to dealing with breast biopsies and reaching a diagnosis. It outlines the procedures used for the microscopic diagnosis of various breast lesions and the significance of the nomenclature and terms used in pathology reports, including those dealing with uncommon or rare lesions. Ample illustrations of the lesions discussed are included, particularly those dealing with uncommon and border-line lesions. There is a special emphasis on breast cancer and on the fact that not all breast cancers are the same. The different ways by which breast cancers are classified are discussed including recent classifications which lead to personalized therapy.

The book is aimed at pathologists of all grades who deal with breast biopsies including those in training. It would be also useful for practicing and trainee surgeons and oncologists as well as other health professionals dealing with patients with breast diseases and scientists carrying out research on breast problems.

Breast Pathology in Clinical Practice 1st Table of contents:

Section I: Introduction to Breast Pathology

1. Overview of Breast Pathology
   • The Role of Breast Pathology in Clinical Practice
   • History and Evolution of Breast Pathology
   • Basic Breast Anatomy and Histology
   • Techniques in Breast Pathology Diagnosis
2. Approach to the Breast Pathology Patient
   • Clinical Evaluation and Diagnostic Workup
   • Imaging Techniques in Breast Disease
   • Core Needle Biopsy and Other Diagnostic Procedures

Section II: Benign Breast Diseases

3. Non-Proliferative Breast Lesions
   • Fibrocystic Changes
   • Simple Cysts
   • Ductal Ectasia and Other Non-Proliferative Lesions
4. Proliferative Breast Lesions without Atypia
   • Epithelial Hyperplasia
   • Sclerosing Adenosis
   • Radial Scars and Complex Sclerosing Lesions
5. Atypical Ductal and Lobular Hyperplasia
   • Atypical Ductal Hyperplasia (ADH)
   • Atypical Lobular Hyperplasia (ALH)
   • Management and Risk Assessment
6. Fibroadenomas and Phyllodes Tumors
   • Clinical Presentation and Pathology of Fibroadenomas
   • Phyllodes Tumors: Classification and Diagnosis
7. Breast Infections and Inflammatory Conditions
   • Acute and Chronic Mastitis
   • Periductal Mastitis and Duct Ectasia
   • Granulomatous Mastitis

Section III: Malignant Breast Diseases

8. Ductal Carcinoma In Situ (DCIS)
   • Pathologic Features of DCIS
   • Subtypes and Classification
   • Diagnosis, Prognosis, and Management
9. Invasive Carcinomas
   • Invasive Ductal Carcinoma (IDC)
   • Invasive Lobular Carcinoma (ILC)
   • Other Rare Invasive Carcinomas
10. Special Types of Breast Cancer
    • Medullary Carcinoma
    • Mucinous Carcinoma
    • Tubular Carcinoma
    • Inflammatory Breast Cancer
11. Breast Cancer Molecular Subtypes
    • Hormone Receptor-Positive and HER2-Positive Breast Cancer
    • Triple-Negative Breast Cancer
    • Molecular Markers and Prognostic Implications
12. Lymph Node and Distant Metastases
    • Patterns of Metastasis in Breast Cancer
    • Lymphatic and Hematogenous Spread
    • Sentinel Lymph Node Biopsy

Section IV: Breast Pathology and Genetics

13. Genetic Syndromes and Breast Cancer
    • Hereditary Breast Cancer: BRCA1 and BRCA2 Mutations
    • Other Genetic Mutations and Syndromes (e.g., Cowden Syndrome, Li-Fraumeni Syndrome)
    • Genetic Testing and Counseling in Breast Cancer
14. Molecular Pathology of Breast Cancer
    • Role of Molecular Markers in Diagnosis and Prognosis
    • Next-Generation Sequencing and Precision Medicine
    • Biomarkers for Targeted Therapies

Section V: Diagnostic and Prognostic Considerations

15. Histopathologic Diagnosis of Breast Cancer
    • Techniques in Histology and Immunohistochemistry
    • Pathologic Grading and Staging of Breast Cancer
    • Prognostic Factors in Breast Cancer
16. Breast Cancer Prognostication and Risk Stratification
    • Predictive Models and Tools for Risk Assessment
    • Role of Pathology in Guiding Treatment Decisions
    • Prognostic Markers in Clinical Practice
17. Breast Cancer Follow-Up and Surveillance
    • Post-Treatment Pathologic Changes and Recurrence
    • Surveillance Guidelines for Breast Cancer Survivors
    • Management of Metastatic Disease

Section VI: Multidisciplinary Approach to Breast Cancer

18. Surgical Pathology in Breast Cancer
    • Role of the Pathologist in Surgical Decisions
    • Evaluation of Surgical Margins and Lymph Nodes
    • Breast Conservation vs. Mastectomy
19. Breast Cancer Therapy: Pathology’s Role
    • Neoadjuvant and Adjuvant Therapies
    • Chemotherapy, Hormonal Therapy, and Targeted Therapies
    • Pathology-Driven Treatment Decisions
20. Radiation Therapy and Pathology
    • Pathologic Effects of Radiation on the Breast
    • Radiation-Induced Changes and Secondary Malignancies

Section VII: Future Directions in Breast Pathology

21. Advances in Breast Pathology
    • Emerging Technologies in Diagnosis and Prognosis
    • Liquid Biopsy and Other Non-Invasive Techniques
    • The Role of Artificial Intelligence and Digital Pathology
22. Challenges and Controversies in Breast Pathology
    • Controversies in Diagnosis and Classification
    • Pathology’s Role in Preventing Overdiagnosis and Overtreatment
    • Challenges in Implementing Personalized Medicine

Appendices

• Glossary of Terms
• Index

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