Bone Marrow Biopsy Pathology A Practical Guide 1st edition by Christine Beham Schmid, Annette Schmitt Graeff ISBN 3662603071 978-3662603079

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ISBN 10: 3662603071 
ISBN 13: 978-3662603079
Author: Christine Beham Schmid, Annette Schmitt Graeff 

This comprehensive, superbly illustrated reference is designed to provide practical diagnostic assistance for hematopathologists when dealing with common and uncommon lesions in bone marrow trephine biopsies (BMTBs). At the heart of the book is a systematic analysis of neoplastic hematological and non-hematological disease entities, with concise identification of the key features of myeloproliferative neoplasms, myelodysplastic syndromes, acute and chronic leukemias, eosinophilia-associated myeloid/lymphoid neoplasms, lymphoproliferative disorders, and selected non-hematopoietic malignancies. Relevant examples of BMTBs are presented, with microscopic description, high-quality photomicrographs, and clinical data. The book also explains how to assess hematopoietic and stromal components of normal BMTBs, identifies the heterogeneous patterns that may be observed in healthy individuals, and analyzes reactive conditions, with particular attention to diagnostic problems andpitfalls.

Bone Marrow Biopsy Pathology A Practical Guide 1st Table of contents:

Part I: Introduction

1. Overview of Bone Marrow Biopsy Pathology
   • Importance of Bone Marrow Biopsy in Hematologic Diagnosis
   • Indications for Bone Marrow Biopsy and Aspiration
   • Overview of Normal Bone Marrow Architecture and Function
2. Bone Marrow Procedure and Technique
   • Bone Marrow Aspiration and Biopsy Techniques
   • Sample Collection, Preparation, and Handling
   • Common Complications and How to Avoid Them

Part II: Normal Bone Marrow

3. Normal Bone Marrow Cellular Composition
   • Hematopoiesis: Erythropoiesis, Leukopoiesis, and Thrombopoiesis
   • Bone Marrow Microenvironment and Stromal Components
   • Age-Related Changes in Bone Marrow
4. Bone Marrow in Health and Disease
   • Bone Marrow in Pregnancy and Infancy
   • Bone Marrow in Aging Adults
   • Variations in Bone Marrow due to Systemic Conditions

Part III: Bone Marrow Disorders

5. Anemia and Related Bone Marrow Disorders
   • Aplastic Anemia: Pathology and Diagnosis
   • Iron Deficiency Anemia and Megaloblastic Anemia
   • Hemolytic Anemia and Myelophthisic Anemia
   • Bone Marrow Changes in Anemia of Chronic Disease
6. Leukemias and Myelodysplastic Syndromes
   • Acute Myeloid Leukemia (AML): Pathology and Classification
   • Chronic Myelogenous Leukemia (CML): Bone Marrow Features
   • Myelodysplastic Syndromes (MDS): Diagnostic Criteria and Morphology
7. Lymphoproliferative Disorders
   • Hodgkin and Non-Hodgkin Lymphomas in the Bone Marrow
   • Plasma Cell Dyscrasias: Multiple Myeloma and Waldenström Macroglobulinemia
   • Chronic Lymphocytic Leukemia (CLL) and Related Conditions
8. Myeloproliferative Disorders
   • Polycythemia Vera: Bone Marrow Features
   • Essential Thrombocythemia and Primary Myelofibrosis
   • Chronic Myeloproliferative Diseases: Diagnostic Features and Markers
9. Bone Marrow Infiltrations and Metastases
   • Metastatic Tumors in the Bone Marrow
   • Bone Marrow Infiltration by Solid Tumors and Sarcomas
   • Granulomatous Diseases and Their Bone Marrow Manifestations

Part IV: Diagnostic Techniques in Bone Marrow Pathology

10. Bone Marrow Histopathology
    • Bone Marrow Biopsy Processing and Staining Techniques
    • Microscopic Examination: Bone Marrow Biopsy and Aspirate
    • Common Artifacts and Pitfalls in Bone Marrow Examination
11. Cytogenetics and Molecular Pathology in Bone Marrow
    • Cytogenetic Analysis in Hematologic Malignancies
    • Role of FISH, PCR, and Next-Generation Sequencing in Diagnosis
    • Molecular Markers in Leukemias and Myelodysplastic Syndromes
12. Immunohistochemistry in Bone Marrow
    • Use of Immunohistochemistry in Diagnosing Lymphomas and Leukemias
    • Antibody Panels for Bone Marrow Diagnostic Workup
    • Application of Immunohistochemistry in Myeloproliferative Disorders

Part V: Special Considerations and Challenges

13. Bone Marrow in Pediatric Patients
    • Pediatric Bone Marrow Disorders: Leukemias, Anemia, and Congenital Conditions
    • Bone Marrow in Pediatric Lymphomas and Hematologic Malignancies
14. Bone Marrow in Elderly Patients
    • Age-Related Changes and Challenges in Elderly Bone Marrow
    • Diagnostic Considerations in Geriatric Bone Marrow Disorders
15. Bone Marrow and Systemic Diseases
    • Bone Marrow in Autoimmune Diseases and Infectious Diseases
    • Bone Marrow in Endocrine and Metabolic Disorders

Part VI: Case Studies and Clinical Applications

16. Case Studies in Bone Marrow Pathology
    • Case 1: Anemia with Iron Deficiency
    • Case 2: Leukemia and Myelodysplastic Syndrome
    • Case 3: Myeloproliferative Disorders and Their Clinical Manifestations
    • Case 4: Lymphoma and Plasma Cell Dyscrasia in the Bone Marrow
17. Clinical and Prognostic Implications of Bone Marrow Findings
    • Grading and Staging of Hematologic Malignancies
    • Prognostic Indicators in Bone Marrow Pathology
    • Role of Bone Marrow Biopsy in Guiding Treatment and Monitoring

Appendices

• Glossary of Bone Marrow Pathology Terms
• Index

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