Platelets in Non Thrombotic Disorders Pathophysiology and Therapeutics an Update 1st edition by Paolo Gresele, Neal Kleiman, José Lopez, Clive Page ISBN 331947460X ‎ 978-3319474601

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ISBN 10: 331947460X ‎
ISBN 13: 978-3319474601
Author:  Paolo Gresele, Neal Kleiman, José Lopez, Clive Page 

This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis

Platelets in Non-Thrombotic Disorders: Pathophysiology and Therapeutics an Update 1st Table of contents:

• Platelet Biology and Function:
  • Overview of platelet structure and the role they play in hemostasis and thrombosis.
  • Examines platelet activation and signaling pathways that govern platelet function.
  • Focuses on how platelets contribute to diseases that don’t necessarily involve thrombotic (clot-forming) processes.
• Non-Thrombotic Disorders Involving Platelets:
  • Explores various conditions in which platelets play a critical role but are not directly associated with clot formation.
  • Includes immune thrombocytopenia, autoimmune diseases, certain cancers, and infections where platelet involvement is more complex.
• Platelets and Inflammation:
  • Investigates the relationship between platelets and inflammation.
  • Describes how platelets can contribute to chronic inflammatory diseases and the mechanisms behind this phenomenon.
  • Covers the role of platelets in autoimmune conditions, rheumatoid arthritis, and other inflammatory disorders.
• Platelets in Cancer:
  • Discusses how platelets are involved in cancer progression, metastasis, and the immune response to tumors.
  • Focuses on the therapeutic implications of targeting platelets in cancer treatment.
  • Reviews how platelets affect tumor growth and the formation of metastases.
• Platelets in Neurodegenerative Disorders:
  • Examines the involvement of platelets in diseases like Alzheimer’s, Parkinson’s, and other neurodegenerative conditions.
  • Discusses the pathological role of platelets in the central nervous system and their potential as biomarkers.
• Platelets in Infectious Diseases:
  • Focuses on the role of platelets in responding to infections, including bacterial and viral diseases.
  • Investigates how platelets contribute to immune responses and how infections may alter platelet function.
• Mechanisms of Platelet Involvement in Disease:
  • Provides insights into the cellular and molecular mechanisms by which platelets participate in non-thrombotic diseases.
  • Discusses signaling pathways, receptors, and other factors that enable platelets to play a role in disease pathogenesis.
• Therapeutic Strategies:
  • Reviews current and emerging therapies aimed at modulating platelet function to treat non-thrombotic disorders.
  • Discusses the use of antiplatelet agents in diseases not typically associated with clotting disorders.
  • Explores the development of new drugs that target platelet signaling pathways.
• Clinical Implications:
  • Focuses on how platelets can be used as therapeutic targets in non-thrombotic disorders.
  • Discusses diagnostic tools for measuring platelet dysfunction and inflammation.
  • Examines the potential for developing platelet-based biomarkers for disease monitoring.
• Emerging Research and Future Directions:
  • Highlights cutting-edge research on the roles of platelets in non-thrombotic diseases.
  • Explores the potential for novel platelet-targeted therapies in a wide range of conditions.
  • Investigates the growing understanding of platelets in diseases that are not traditionally considered to involve these cells.
• Platelet Involvement in Cardiovascular Disease:
  • Although primarily focused on non-thrombotic disorders, the book also touches on how platelets contribute to cardiovascular diseases beyond thrombosis, including atherosclerosis and vascular inflammation.
• Comprehensive Overview:
  • Provides an up-to-date, comprehensive review of the latest advances in platelet research, particularly in relation to their non-thrombotic roles.
  • Summarizes key findings from clinical studies and laboratory research into platelet biology.

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