Immuno Oncology Cellular and Translational Approaches 1st edition by Seng Lai Tan ISBN 1071601709‎ 978-1071601709

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Product details:

ISBN 10: 1071601709‎ 
ISBN 13: 978-1071601709
Author:  Seng Lai Tan 

his book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action. The detailed chapters within will provide readers with a baseline understanding of the pros and cons as well as key considerations for applying assays that are more reflective of the human immune-tumor microenvironment in order to increase their translatability into the clinic. Written for the Methods in Pharmacology and Toxicology series, the contents of this volume include the kind of specifics and real-world implementation advice to ensure success in the lab.
Authoritative and practical, Immuno-Oncology: Cellular and Translational Approaches aims to aid researchers working on biotechnology and pharmaceutical efforts to search for the next generation of safer and more effective cancer immunotherapeutics.

Immuno-Oncology: Cellular and Translational Approaches 1st Table of contents:

• Cellular Approaches: The book delves into the immunological mechanisms involved in the interaction between cancer cells and the immune system. It discusses the role of immune cells like T-cells, dendritic cells, natural killer cells, and macrophages in targeting and eliminating tumor cells.

• Translational Approaches: It emphasizes how laboratory research on immunology is being translated into clinical applications for cancer therapy. This includes discussing the challenges and strategies for applying basic research in real-world clinical settings.

• Immune Checkpoint Inhibition: A key topic likely covered in the book is the use of immune checkpoint inhibitors, such as PD-1/PD-L1 inhibitors and CTLA-4 inhibitors, which have revolutionized cancer therapy.

• Chimeric Antigen Receptor (CAR) T-Cell Therapy: Another area likely covered is CAR-T cell therapy, which involves genetically modifying a patient’s T-cells to express receptors specific to tumor antigens.

• Cancer Vaccines: The book likely discusses the development of cancer vaccines designed to activate the immune system against specific tumor markers.

• Cancer Microenvironment: It also explores how the tumor microenvironment influences immune responses and how it can be manipulated to enhance immunotherapy efficacy.

• Biomarkers for Immunotherapy: Biomarkers for predicting the response to immunotherapy, such as tumor mutational burden (TMB) or microsatellite instability (MSI), may also be discussed.

• Emerging Therapies: The book highlights cutting-edge immuno-oncology therapies in development, such as oncolytic virotherapy, bispecific antibodies, and other novel immune modulators.

• Combination Therapies: Immuno-oncology is increasingly being explored in combination with other treatment modalities, including chemotherapy, radiation, and targeted therapies. The book likely discusses various combination strategies.

• Challenges and Future Directions: Challenges such as immune-related adverse events, resistance mechanisms, and the need for personalized treatment approaches are likely addressed, along with the future directions of research and therapy in this exciting field.

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