Bacterial Type III Protein Secretion Systems 1st Edition by Samuel Wagner, Jorge E Galan ISBN 3030521230 9783030521233
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Authors:Samuel Wagner; Jorge E. Galan , Series:Pathology [212] , Tags:Medical; Microbiology; Infectious Diseases; Science; Life Sciences; Bacteriology; General; (Current Topics in Microbiology and Immunology 427) , Author sort:Wagner, Samuel & Galan, Jorge E. , Ids:Google; 9783030521233 , Languages:Languages:eng , Published:Published:Aug 2020 , Publisher:Springer Nature , Comments:Comments:One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into eukaryotic and prokaryotic target cells to modulate a variety of cellular functions for the pathogen’s benefit. These protein-delivery machines include the type III secretion system (T3SS), which is widespread in nature and encoded not only by bacteria pathogenic to vertebrates or plants, but also by bacteria that are symbiotic to plants or insects. Because they are essential virulence factors for many important human pathogens, these systems are emerging as a prime target for the development of new-generation, anti-infective drugs. This book reviews our current understanding of these intriguing injection machines as well as of the closely related T3SS that serves in flagella assembly. Individual chapters focus on regulation, assembly, structure, and function of the type III secretion machine and on the evolution of the secreted effector proteins. Given its scope, this book will appeal to a broad readership, including researchers and teachers in the fields of infectious diseases, host pathogen interactions, plant and animal pathogenesis, and symbiosis.
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ISBN 10: 3030521230
ISBN 13: 9783030521233
Author: Samuel Wagner, Jorge E Galan
One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into eukaryotic and prokaryotic target cells to modulate a variety of cellular functions for the pathogen’s benefit. These protein-delivery machines include the type III secretion system (T3SS), which is widespread in nature and encoded not only by bacteria pathogenic to vertebrates or plants, but also by bacteria that are symbiotic to plants or insects. Because they are essential virulence factors for many important human pathogens, these systems are emerging as a prime target for the development of new-generation, anti-infective drugs. This book reviews our current understanding of these intriguing injection machines as well as of the closely related T3SS that serves in flagella assembly. Individual chapters focus on regulation, assembly, structure, and function of the type III secretion machine and on the evolution of the secreted effector proteins. Given its scope, this book will appeal to a broad readership, including researchers and teachers in the fields of infectious diseases, host pathogen interactions, plant and animal pathogenesis, and symbiosis.
Bacterial Type III Protein Secretion Systems 1st Table of contents:
A Unified Nomenclature for Injectisome-Type Type III Secretion Systems
Transcriptional and Post-transcriptional Regulatory Mechanisms Controlling Type III Secretion
Assembly and Post-assembly Turnover and Dynamics in the Type III Secretion System
The Structure of the Type III Secretion System Needle Complex
Molecular Organization and Assembly of the Export Apparatus of Flagellar Type III Secretion Systems
Structures of Type III Secretion System Needle Filaments
The Type III Secretion System Sorting Platform
Export Mechanisms and Energy Transduction in Type-III Secretion Machines
Flagellar Hook/Needle Length Control and Secretion Control in Type III Secretion Systems
The Tip Complex: From Host Cell Sensing to Translocon Formation
Diversity and Evolution of Type III Secreted Effectors: A Case Study of Three Families
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