ESC Textbook of Vascular Biology The European Society of Cardiology Series 1st Edition by Rob Krams, Magnus Back ISBN 0198755775 9780198755777

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ISBN 10: 0198755775
ISBN 13: 9780198755777
Author: Rob Krams, Magnus Back

Atherosclerosis is the most significant cause of cardiovascular disease worldwide. Vascular biology is the key to understanding how atherosclerosis arises and operates. The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.

The textbook covers molecular findings and novel targets within the speciality while also providing the basics of vascular biology and disease pathophysiology. It also covers the major changes in the diagnosis, prevention and treatment of atherosclerosis that have occurred in recent years, developments and recent breakthroughs in the field are specifically highlighted.

The official publication of the ESC Working Group on Arthrosclerosis and Vascular Biology, this print edition comes with access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables.

The textbook is also linked to the ESC’s online learning platform (ESCel) and their core specialist training curriculum (ESC Core Curriculum). The textbook particularly appeals to vascular biologists, cardiologists, and other practising clinicians.

ESC Textbook of Vascular Biology The European Society of Cardiology Series 1st Table of contents:

Chapter 1: Introduction to Vascular Biology

• Overview of Vascular Biology and Its Role in Health and Disease
• Historical Perspectives in Vascular Biology
• Key Concepts and Terminology
• Importance of Vascular Biology in Cardiovascular Medicine

Chapter 2: Vascular Structure and Function

• Basic Anatomy of the Vasculature: Arteries, Veins, and Capillaries
• Endothelial Cells: Structure and Function
• Smooth Muscle Cells and Their Role in Vascular Tone
• The Extracellular Matrix and Vascular Remodeling
• Vascular Inflammation and Its Impact on Function

Chapter 3: Vascular Endothelium and Its Role in Vascular Homeostasis

• Endothelial Cell Function in Vascular Health
• Nitric Oxide and Endothelial Nitric Oxide Synthase (eNOS)
• Endothelial Dysfunction and Its Implications in Cardiovascular Disease
• Endothelial Regeneration and Repair Mechanisms
• The Role of Endothelium in Blood Pressure Regulation

Chapter 4: Vascular Smooth Muscle Cells and Remodeling

• Function and Plasticity of Vascular Smooth Muscle Cells
• Mechanisms of Vascular Remodeling in Health and Disease
• Smooth Muscle Cells in Atherosclerosis and Arteriosclerosis
• Vascular Smooth Muscle Cells in Hypertension
• Molecular Pathways of Smooth Muscle Cell Proliferation and Migration

Chapter 5: The Immune System and Vascular Biology

• Immune Responses in Vascular Disease
• Inflammation and Atherosclerosis: Mechanisms and Pathways
• The Role of T Cells, Macrophages, and Cytokines in Vascular Disease
• Vascular Immune Responses in Diabetes, Hypertension, and Stroke
• Immunomodulation and Therapeutic Approaches

Chapter 6: Vascular Biology in Atherosclerosis

• The Role of Endothelial Dysfunction in Atherogenesis
• Lipids and Lipoproteins in Vascular Biology
• Mechanisms of Plaque Formation and Progression
• Vascular Remodeling in Atherosclerosis
• Vulnerable Plaques and Their Clinical Implications

Chapter 7: Vascular Biology in Hypertension

• Pathophysiology of Hypertension and Vascular Dysfunction
• The Role of Endothelial Cells and Smooth Muscle in Hypertension
• Vascular Remodeling in Chronic Hypertension
• The Renin-Angiotensin-Aldosterone System in Vascular Biology
• Emerging Therapeutic Targets in Hypertension

Chapter 8: Vascular Biology in Peripheral Artery Disease

• Mechanisms of Disease Development in Peripheral Artery Disease (PAD)
• Role of Endothelial Dysfunction and Smooth Muscle in PAD
• Vascular Remodeling in PAD
• Clinical Assessment and Management of PAD
• Advances in Therapeutic Approaches to PAD

Chapter 9: Vascular Biology in Stroke and Cerebrovascular Disease

• The Role of Vascular Biology in Stroke Pathophysiology
• Cerebral Vascular Remodeling in Stroke and Transient Ischemic Attacks
• Endothelial Dysfunction and Blood-Brain Barrier Integrity
• Mechanisms of Cerebral Atherosclerosis and Small Vessel Disease
• Vascular Therapeutic Strategies in Stroke

Chapter 10: Vascular Biology in Diabetes

• Impact of Diabetes on Vascular Biology
• Endothelial Dysfunction in Diabetes and Cardiovascular Risk
• Role of Advanced Glycation End-products (AGEs) in Vascular Disease
• Diabetic Microvascular Disease: Mechanisms and Management
• Emerging Therapeutic Strategies for Vascular Protection in Diabetes

Chapter 11: Vascular Aging and Vascular Disease

• Mechanisms of Vascular Aging
• Age-related Changes in Vascular Structure and Function
• Endothelial Dysfunction and Increased Arterial Stiffness with Aging
• Vascular Remodeling in Aging and Cardiovascular Risk
• Strategies for Preventing Age-related Vascular Disease

Chapter 12: Molecular and Cellular Mechanisms in Vascular Biology

• Molecular Signaling Pathways in Vascular Cells
• The Role of Growth Factors, Cytokines, and Chemokines
• Angiogenesis and Vascular Repair Mechanisms
• Vascular Stem Cells and Their Role in Regeneration
• Epigenetics in Vascular Biology

Chapter 13: Vascular Biology and Cancer

• Tumor Angiogenesis and Its Role in Cancer Progression
• Mechanisms of Vascular Remodeling in Tumors
• Endothelial Cells and the Tumor Microenvironment
• Targeting Vascular Biology in Cancer Therapy
• Clinical Approaches to Anti-angiogenic Therapy

Chapter 14: Therapeutic Approaches in Vascular Biology

• Pharmacological Strategies to Target Vascular Dysfunction
• Gene Therapy and Stem Cell Approaches in Vascular Regeneration
• Surgical and Interventional Approaches to Vascular Disease
• The Role of Biomarkers in Vascular Disease Management
• Future Directions in Vascular Biology Therapies

Chapter 15: The Role of Vascular Biology in Cardiovascular Risk Management

• Vascular Health and Global Cardiovascular Risk Assessment
• The Role of Lifestyle Modifications in Vascular Health
• Early Detection and Prevention of Vascular Disease
• The Role of Biomarkers in Cardiovascular Risk Prediction
• Personalized Approaches to Vascular Disease Prevention

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