Platelet Rich Fibrin in Regenerative Dentistry Biological Background and Clinical Indications 1st Edition by Richard Miron, Joseph Choukroun ISBN 1119406815 9781119406815

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ISBN 10:       1119406815
ISBN 13: 978-1119406815
Author:        Richard J. Miron, Joseph Choukroun 

The first book devoted exclusively to the subject, Platelet Rich Fibrin in Regenerative Dentistry offers comprehensive, evidence-based coverage of the biological basis and clinical applications of PRF in dentistry. Co-edited by a leading researcher in tissue regeneration and the inventor of the PRF technique, it brings together original contributions from expert international researchers and clinicians.

Chapters cover the biological foundation of PRF before addressing specific uses of the technology within clinical dentistry. Topics describe the use of PRF in many dental applications, including extraction socket management, sinus lifting procedures, root coverage, periodontal regeneration, soft tissue healing around implants, guided bone regeneration, and facial esthetics. The text is supplemented with color photographs and explanatory illustrations throughout.

Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical Indications is an indispensable professional resource for periodontists, oral surgeons and oral and maxillofacial surgeons, as well as general dentists who use PRF or are interested in introducing it into their practices. It is also an excellent reference for undergraduate and postgraduate dental students.

Platelet Rich Fibrin in Regenerative Dentistry Biological Background and Clinical Indications 1st Table of contents:

1. Platelet Rich Fibrin: A Second-Generation Platelet Concentrate

1.1 Introduction
1.2 Brief History of Platelet Concentrates
1.3 Development of PRF from PRP
1.4 Effect of PRF on Periosteum Behavior
1.5 The First Case Treated with PRF
1.6 Conclusion
References

2. Biological Components of Platelet Rich Fibrin: Growth Factor Release and Cellular Activity

2.1 Introduction
2.2 Cell Components of PRF
2.3 Advantages of a Three-Dimensional Fibrin Network
2.4 Growth Factors in Blood
2.5 PRP versus PRF for Growth Factor Release
2.6 L-PRF vs A-PRF vs A-PRF+: New Findings with the Low-Speed Centrifugation Concept and Low-Time Induced Growth Factor Release
2.7 i-PRF vs PRP: Growth Factor Release
2.8 Cell Behavior in Response to L-PRF, A-PRF, and A-PRF+
2.9 Cell Behavior in Response to PRP, i-PRF
2.10 Future Prospects
References

3. Introducing the Low-Speed Centrifugation Concept

3.1 Introduction
3.2 Development of Advanced Solid PRF Matrices Using LSCC
3.3 Development of Injectable PRF (i-PRF) Using LSCC
3.4 Platelets and Leukocytes as Key Elements in Regeneration
3.5 Clinical Insights
3.6 Conclusion
References

4. Uses of Platelet Rich Fibrin in Regenerative Dentistry: An Overview

4.1 Introduction
4.2 Extraction Socket Management with PRF
4.3 Sinus Elevation Procedures with PRF
4.4 PRF for Soft-Tissue Root Coverage
4.5 PRF for Periodontal Regeneration
4.6 PRF for Regeneration of Soft Tissues Around Implants
4.7 PRF in Guided Bone Regeneration
4.8 PRF in Other Aspects of Dentistry and Medicine
4.9 Conclusion
References

5. Use of Platelet Rich Fibrin for the Management of Extraction Sockets: Biological Basis and Clinical Relevance

5.1 Introduction
5.2 Natural Dimensional Changes Post-Extraction
5.3 Conventional Socket Grafting and Ridge Preservation Techniques
5.4 Immediate Implant Placement into Fresh Extraction Sockets
5.5 Utilizing PRF in Extraction Sockets
5.6 Discussion and Future Research
References

6. Maxillary Sinus Floor Elevation in the Atrophic Posterior Maxillae: Anatomy, Principles, Techniques, Outcomes, and Complications

6.1 Introduction
6.2 Anatomical Considerations
6.3 Biological Principles
6.4 Surgical Techniques
6.5 Clinical Outcomes
6.6 Surgical and Post-Surgical Complications
6.7 Conclusion
References

7. Maxillary Sinus Floor Elevation Procedures with Platelet Rich Fibrin: Indications and Clinical Recommendations

7.1 Introduction
7.2 PRF as a Sole Grafting Material During Sinus Lifting Procedures
7.3 PRF for Repair of Schneiderian Membranes
7.4 PRF for Lateral Maxillary Access Window Closure
7.5 Discussion and Future Outlook
References

8. Use of Platelet Rich Fibrin for Treatment of Muco-Gingival Recessions: Fibrin Assisted Soft Tissue Promotion (FASTP) Technique

8.1 Introduction
8.2 Plastic Periodontal Procedures with PRF
8.3 Fibro Promotion: Mechanism of FASTP
8.4 FASTP Surgical Technique
8.5 Conclusion
References

9. Use of Platelet Rich Fibrin for Periodontal Regeneration/Repair of Intrabony and Furcation Defects

9.1 Introduction
9.2 Role of Barrier Membranes in Periodontal Regeneration
9.3 Role of Bone-Grafting Materials in Periodontal Regeneration
9.4 Biologic Agents/Growth Factors for Periodontal Regeneration
9.5 PRF as an Autologous Biological Agent for Periodontal Regeneration
9.6 Intrabony Defect Regeneration with PRF: Clinical Trials
9.7 Furcation Defect Regeneration with PRF
9.8 Discussion and Future Research
References

10. Platelet Rich Fibrin as an Adjunct to Implant Dentistry

10.1 Introduction
10.2 PRF Treatment of Peri-Implant Defects
10.3 PRF and Soft-Tissue Healing at Implants
10.4 Osseointegration
10.5 Techniques to Improve Primary Stability in Poor Bone Quality
10.6 Use of PRF in Osteotomy Preparation
10.7 Future of PRF in Implant Dentistry
References

11. Guided Bone Regeneration with Platelet Rich Fibrin

11.1 Introduction
11.2 Overview of GBR
11.3 Available GBR Options
11.4 Non-Resorbable PTFE Membranes
11.5 Titanium Mesh
11.6 Collagen-Based Resorbable Membranes
11.7 Synthetic Resorbable Membranes
11.8 Plasma-Rich Proteins as Growth Factors for Membranes
11.9 Choice of Bone-Grafting Materials for GBR
11.10 Alternative Strategies for Bone Formation in GBR
11.11 Recent Surgical Approaches Using PRF in GBR
11.12 PRF as a Barrier Membrane in GBR
11.13 PRF with Bone-Grafting Materials in GBR
11.14 Studies on PRF for GBR
11.15 Discussion and Future Research
References

12. Modern Approach to Full Arch Immediate Loading: Simonpieri Technique with PRF and i-PRF

12.1 Introduction
12.2 Immediate Loading in Implant Dentistry: Success Factors
12.3 Biological, Anatomical, and Surgical Requirements
12.4 Prosthetic Requirements
12.5 Final Results
12.6 Documented Long-Term Stability
12.7 Long-Term Statistical Results: Full Arch Immediate Implant Placement and Loading
12.8 Conclusion
References

13. Use of Platelet Rich Fibrin in Facial Aesthetics and Rejuvenation

13.1 Introduction
13.2 Skin Features and Aging
13.3 Epidermal Barrier Function in Skin Aesthetics
13.4 Pre-Evaluation and Patient Selection
13.5 Conventional Facial Aesthetic Therapies
13.6 Lasers and Epidermal Barrier Function
13.7 PRF in Facial Aesthetics
13.8 Clinical Procedures Using PRF
13.9 i-PRF Injections with Dermarollers/Pens
13.10 PRF for Mesotherapy and Augmentation Techniques
13.11 PDO Threads with PRF
13.12 Conclusion
References

14. Use of Platelet Rich Fibrin in Other Areas of Medicine

14.1 Introduction
14.2 Effects of PRF on Cell Activity In Vitro
14.3 PRF for Soft-Tissue Wound Healing and Regeneration
14.4 Clinical Studies on PRF in Medicine
14.5 PRF for Chronic Leg Ulcer Regeneration
14.6 PRF for Cartilage and Tendon Regeneration
14.7 PRF in Orthopedics and Skin Regeneration
14.8 Discussion and Future Perspectives
References

15. Future Research with Platelet Rich Fibrin

15.1 PRF and Centrifugation Speeds
15.2 Effect of Hematocrit Count on PRF Scaffolds
15.3 PRF for Osteonecrosis Treatment
15.4 PRF for Temporomandibular Joint Disorders
15.5 Potential of PRF in Pulp Regeneration
15.6 PRF and Periodontal Regeneration
15.7 Stem Cells from Blood in PRF
15.8 Regeneration by Growth Factors, Leukocytes, or Fibrin
15.9 PRF and Its Degradation Properties
15.10 PRF and Osteoinduction
References

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