Dental Stem Cells Stem Cell Biology and Regenerative Medicine 1st Edition by Fikrettin Åžahin, Aysegul Dogan, Selami Demirci ISBN 3319289454 9783319289458

Dental Stem Cells Stem Cell Biology and Regenerative Medicine 1st Edition by Fikrettin Şahin, Ayşegül Doğan, Selami Demirci – Ebook PDF Instant Download/Delivery. 3319289454, 978-3319289458
Full download Dental Stem Cells Stem Cell Biology and Regenerative Medicine 1st Edition after payment

 

Product details:

ISBN 10:       3319289454
ISBN 13: 978-3319289458
Author:    Fikrettin Şahin, Ayşegül Doğan, Selami Demirci     

This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field. The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells.
Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer’s Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine.

Dental Stem Cells Stem Cell Biology and Regenerative Medicine 1st Table of contents:

Chapter 1: Dental and Craniofacial Tissue Stem Cells: Sources and Tissue Engineering Applications
1.1 Introduction
1.2 Dental Tissue Development and Repair
   1.2.1 Dentinogenesis
1.3 Stem Cell Populations
   1.3.1 BMMSCs
   1.3.2 Adipose Tissue-Derived Stem Cells (ADSCs)
   1.3.3 Dental Tissue Stem Cells
      1.3.3.1 Postnatal Dental Tissue-Derived Stem Cells
      1.3.3.2 Stem Cells Derived from Developing Dental Tissue
      1.3.3.3 Oral Mucosal and Periosteum-Derived Stem Cells
      1.3.3.4 Salivary Gland-Derived Stem Cells
      1.3.3.5 Induced Pluripotent Stem Cells (iPSCs)
1.4 Scaffolds and Morphogens for Stem Cell Tissue Engineering
   1.4.1 Scaffolds
   1.4.2 Role of Growth Factors and Morphogens for Tissue Regeneration
1.5 Stem Cell Applications for Dental and Craniofacial Tissue Regeneration
   1.5.1 Tooth and Tooth Component Tissue Regeneration
   1.5.2 Regeneration of Other Complex Craniofacial Tissues and Organs
1.6 Stem Cell Storage and Processing
1.7 Concluding Remarks
References

---

Chapter 2: Immunomodulatory Properties of Stem Cells Derived from Dental Tissues
2.1 Mesenchymal Stem Cell (MSC)-Mediated Immunomodulation
   2.1.1 Interactions of MSCs with White Blood Cells
      2.1.1.1 T Lymphocyte-Mediated Suppression
      2.1.1.2 B Lymphocyte-Mediated Suppression
      2.1.1.3 Dendritic Cell-Mediated Suppression
      2.1.1.4 Natural Killer Cell (NKs)-Mediated Suppression
2.2 Immuno-Modulation of DSCs
   2.2.1 DPSCs
   2.2.2 PDLSCs
   2.2.3 TGSCs
   2.2.4 GMSCs
   2.2.5 SCAPs
   2.2.6 SHEDs
2.3 Relation Between Immunosuppression and Stem Cell Expression Profiles
2.4 Clinical Applications
2.5 Safety Issues
2.6 MSC Paradigm; Suppression or Modulation
2.7 Conclusion
References

---

Chapter 3: miRNA Regulation in Dental Stem Cells: From Development to Terminal Differentiation
3.1 Introduction
3.2 Stem Cells and miRNAs
   3.2.1 Regulation of Stemness Properties by miRNAs
   3.2.2 miRNAs in MSCs
   3.2.3 miRNA Regulation of Pathways Active in MSCs
3.3 miRNAs in DSCs, Dental Tissues and Their Roles
3.4 Regulation of Developmental Stages of Tooth by miRNAs
   3.4.1 Initiation, Lamina and Placode Stages
   3.4.2 Bud Stage
   3.4.3 Cap Stage
   3.4.4 Bell Stage
   3.4.5 Late Bell Stage
   3.4.6 Tooth Eruption
3.5 Role of miRNAs in Differentiation of DSCs
   3.5.1 Odontogenic Differentiation
   3.5.2 Osteogenic Differentiation
   3.5.3 Other Lineages
3.6 Expression of miRNA in Dental Tissues and Stem Cell Niche
3.7 Future Directions
References

---

Chapter 4: Signaling Pathways in Dental Stem Cells During Their Maintenance and Differentiation
4.1 Introduction
4.2 Signaling Pathways in DSC Maintenance/Homeostasis
   4.2.1 Notch Signaling Pathway
   4.2.2 SHH Signaling Pathway
   4.2.3 MAPK Signaling Pathway
   4.2.4 Eph-Ephrin Signaling Pathway
4.3 Signaling Pathways in DSC Migration
   4.3.1 MAPK Signaling Pathway
   4.3.2 PI3K/AKT Signaling Pathway
   4.3.3 Eph-Ephrin Signaling Pathway
4.4 Signaling Pathways in DSC Proliferation
   4.4.1 MAPK Signaling Pathway
   4.4.2 PI3K/AKT Signaling Pathway
   4.4.3 NF-κB Signaling Pathway
   4.4.4 Notch Signaling Pathway
   4.4.5 Wnt/β-Catenin Signaling Pathway
   4.4.6 Other Signaling Pathways
4.5 Signaling Pathways in DSC Differentiation
   4.5.1 TGF-β Signaling Pathway
   4.5.2 BMPs Signaling Pathway
   4.5.3 NF-κB Signaling Pathway
   4.5.4 MAPK Signaling Pathway
   4.5.5 mTOR Signaling Pathway
   4.5.6 Wnt/β-Catenin Signaling Pathway
   4.5.7 Other Signaling Pathways
4.6 Signaling Pathway Networks
4.7 Conclusions and Prospects
References

---

Chapter 5: Genetically Engineered Dental Stem Cells for Regenerative Medicine
5.1 Introduction
5.2 Genetic Modification of MSCs and Their Biomedical Applications
   5.2.1 Viral Nucleic Acid Transfer Techniques
   5.2.2 Non-Viral Methods for Nucleic Acids Transfer
5.3 Genetic Modification for Cell Immortalization
5.4 Genetic Modification for Modulation of Cell Phenotype and Osteo- and Odontogenic Differentiation
5.5 Genetic Modification for Enhanced Angiogenesis
5.6 Conclusion
References

---

Chapter 6: Dental Stem Cells vs. Other Mesenchymal Stem Cells: Their Pluripotency and Role in Regenerative Medicine
6.1 Introduction
6.2 Pluripotency of DSCs
   6.2.1 Pluripotency: Definition, Assessment and Markers
   6.2.2 Pluripotency of MSCs
   6.2.3 Pluripotent Characteristics of DSCs
6.3 DSCs vs. Other MSCs
6.4 Conclusion
References

---

Chapter 7: Induced Pluripotent Stem Cells Derived from Dental Stem Cells: A New Tool for Cellular Reprogramming
7.1 Introduction
7.2 DTs as a Source of Stem Cells (SCs)
7.3 Expression of Pluripotent Markers in DSCs
7.4 DSC Reprogramming
7.5 Factors Relevant in Reprogramming
7.6 Transcription Factor Expression in DSC-Derived iPSCs
7.7 Differentiation Potential
7.8 DSC-Derived iPSCs and Disease Modeling
7.9 Drug Discovery and Cytotoxicity Studies
7.10 Regenerative Medicine and Cell Therapy
7.11 Near and Not-So-Near Future
References

---

Chapter 8: Dental Stem Cells in Oral, Maxillofacial, and Craniofacial Regeneration
8.1 Overview
8.2 Mesenchymal Stem Cells (MSCs)
8.3 Dental Stem Cells (DSCs)
   8.3.1 DPSCs
   8.3.2 SHEDs
   8.3.3 SCAPs
   8.3.4 PDLSCs
   8.3.5 DFSCs
8.4 DSC Niches
8.5 DSC Isolation and Characterization
8.6 Dentin/Pulp Regeneration
8.7 Bone Regeneration
8.8 Neural Tissue Regeneration
8.9 Vascular Tissue Regeneration
8.10 Muscle Tissue Regeneration
8.11 Cartilage Tissue Regeneration
8.12 Adipose Tissue Regeneration
References

---

Chapter 9: Dental Stem Cells: Possibility for Generation of a Bio-Tooth
9.1 Introduction
9.2 Stem Cells in Dentistry
   9.2.1 Stem Cell Studies in Reconstruction of Cranio-Facial Tissues
   9.2.2 Stem Cell Studies in Periodontal and Peri-Implant Regeneration
   9.2.3 Stem Cell Studies in Pulp Regeneration
   9.2.4 Stem Cells in Tooth Development, Bio-Tooth or Bio-Root
9.3 Oral/Dental Tissue-Derived MSCs
   9.3.1 Oral Tissue-Derived MSCs
      9.3.1.1 Gingiva-Derived MSCs
      9.3.1.2 Oral Mucosa-Derived MSCs
      9.3.1.3 Palatal Connective Tissue-Derived MSCs
      9.3.1.4 Palatal Adipose Tissue-Derived MSCs
   9.3.2 Dental-Derived MSCs
      9.3.2.1 Dental Follicle-Derived MSCs (DFSCs)
      9.3.2.2 Apical Papilla-Derived MSCs
      9.3.2.3 PDLSCs
      9.3.2.4 DPSCs (Natal, Deciduous, and Adult)
9.4 Induced Pluripotent Stem (iPS) Cells in Dentistry
9.5 Current Approaches in the Treatment of Missing Teeth
9.6 Future Prospects of Stem Cells in Dentistry
   9.6.1 Utility of Stem Cells to Create Whole Tooth Organ
   9.6.2 What is Bio-Tooth? Is It Possible?
      9.6.2.1 Cell-Based Tooth Regeneration
      9.6.2.2 Using Epithelial and Mesenchymal Cells Derived from Dental Sources
      9.6.2.3 Using Epithelial or Mesenchymal Cells from Non-Dental Sources
      9.6.2.4 Scaffold and Cell-Based Tooth Regeneration
9.7 Biomaterials
   9.7.1 Bio-Implant vs. Bio-Tooth?
9.8 Conclusion and Future Trends or Directions
References

---

Chapter 10: Dental Stem Cells for Bone Tissue Engineering
10.1 Introduction
10.2 DSCs as Candidate Seed Cells for Bone Tissue Engineering
   10.2.1 In Vitro Properties of DSCs
   10.2.2 In Vivo Osteogenesis of DSCs
10.3 Effect of Matrices and Scaffold on DSC-Mediated Bone Tissue Engineering
   10.3.1 Categories of Materials
   10.3.2 Material Features
10.4 Growth Factors in DSC-Mediated Bone Tissue Engineering
   10.4.1 BMPs
   10.4.2 IGFs
   10.4.3 bFGF
   10.4.4 TGF-β
   10.4.5 VEGF
10.5 Clinical Application of DSCs for Bone Regeneration
10.6 Challenges and Future Directions

People also search for Dental Stem Cells Stem Cell Biology and Regenerative Medicine 1st:

sources of dental stem cells
best source of dental stem cells
harvesting dental stem cells
application of dental stem.cells
different types of dental stem cells