Oral Wound Healing Cell Biology and Clinical Management 1st Edition by Hannu Larjava ISBN 0813804817 9780813804811

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ISBN 10:       0813804817
ISBN 13: 978-0813804811
Author:        Hannu Larjava

Oral Wound Healing: Cell Biology and Clinical Management 1st  Table of contents:

1. Oral Wound Healing: An Overview
Hannu Larjava

• Clotting and inflammation (chapters 2, 3, and 4)
• Re-epithelialization and granulation tissue formation (chapters 5 and 6)
• Angiogenesis (chapter 7)
• Healing of extraction sockets (chapter 8)
• Flap design for periodontal wound healing (chapter 9)
• Regeneration of periodontal tissues (chapters 10 and 11)
• Osteointegration and soft tissue healing around dental implants (Chapter 12)
• The pulp healing process (Chapter 13)
• Dermal wound healing and burn wounds (Chapter 14)
• Healing of large dentofacial defects (Chapter 15)
• References

2. Hemostasis, Coagulation and Complications
Carol Oakley and Hannu Larjava

• Introduction
• Primary hemostasis
• Secondary hemostasis and the coagulation system
• Tertiary hemostasis
• Tissue factor
• Von Willebrand factor
• Other coagulation factors
• Cell-centric model of hemostasis: from initiation to propagation
• The procoagulant membrane
• Membrane particles
• Endothelium and hemostasis
• Pro- and anticoagulant functions
• Platelets
• Coagulation and wound healing
• Limitations of the waterfall cascade model and screening laboratory tests
• Implications for laboratory tests
• Pre-surgical evaluation to prevent bleeding problems
• Conclusions
• References

3. Inflammation and Wound Healing
Anna Turabelidze and Luisa Ann DiPietro

• Introduction
• The innate immune response in wounds
• Inflammatory cell infiltration into wounds
• Inflammatory cell function in wounds
• Cytokines and chemokines in wounds
• Inflammation in oral mucosal wounds
• Inflammation in fetal wounds
• Role of inflammation in keloids
• Inflammation and diabetic wounds
• Conclusions
• References

4. Specialized Pro-resolving Lipid Derived Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis
Gabrielle Fredman and Charles N. Serhan

• Inflammation: the cardinal signs
• Complete resolution and tissue homeostasis is the ideal outcome of acute inflammation
• Lipoxins, resolvins, protectins, and maresins: semper vigilantes of anti-inflammation and pro-resolution
• Resolution of inflammation is an actively regulated process in vivo
• Resolvins and protectins are protective in experimental models of inflammatory diseases
• Specialized pro-resolving lipid mediators in oral medicine: restoration of tissue homeostasis in experimental periodontitis
• Resolution and wound healing
• Anti-inflammation vs. Pro-resolution
• Clinical implications and the development of stable analogs
• Conclusions
• Acknowledgments
• References

5. Re-epithelialization of Wounds
Leeni Koivisto, Lari Häkkinen, and Hannu Larjava

• Introduction
• Keratinocytes form a protective barrier between an organism and its environment
• Keratinocytes are activated rapidly to restore the epithelial barrier after wounding
• Many different factors contribute to re-epithelialization
• Final stages of re-epithelialization
• Failure to re-epithelialize: chronic wounds
• Conclusions
• References

6. Granulation Tissue Formation and Remodeling
Lari Häkkinen, Hannu Larjava, and Leeni Koivisto

• Introduction
• Overview of connective tissue response to wounding
• Wound healing stages
• Origin and identity of wound fibroblasts
• Granulation tissue formation
• Connective tissue remodeling
• Re-emergence of quiescent fibroblast phenotype
• Specific features of oral mucosal wound healing
• Conclusions
• Acknowledgments
• References

7. Angiogenesis and Wound Healing: Basic Discoveries, Clinical Implications, and Therapeutic Opportunities
Peter J. Polverini

• Introduction
• How blood vessels develop
• Early mechanistic insights into the angiogenic response: from solid tumors to chronic inflammation and wound healing
• The role of other inflammatory cells in angiogenesis
• Matrix molecules
• Vascular endothelial growth factor and the modern era of angiogenesis research
• Signaling networks of potential importance in wound neovascularization
• Inhibitors of angiogenesis: important counterweights in wound neovascularization
• The role of aberrant wound angiogenesis in the pathogenesis of diabetes mellitus
• Conclusions
• References

8. Wound Healing of Extraction Sockets
Roberto Farina and Leonardo Trombelli

• Healing of extraction sockets
• Factors influencing the healing of extraction sockets
• Healing of extraction sockets following immediate implant placement
• Does the use of reconstructive technologies alter the healing of extraction sockets?
• Conclusions
• References

9. Flap Designs for Periodontal Healing
Leonardo Trombelli and Roberto Farina

• Flap management, wound stability, and periodontal regeneration
• Flap designs to achieve primary closure
• Surgical treatment of periodontal intraosseous defects: technical hints
• Conclusions
• References

10. Periodontal Regeneration: Experimental Observations – Clinical Consequences
Ulf M.E. Wikesjö, Cristiano Susin, Jaebum Lee, Douglas P. Dickinson, and Giuseppe Polimeni

• Introduction
• Wound healing
• Periodontal wound healing
• Periodontal regeneration – new attachment
• Wound stability
• Space provision
• Wound closure for primary intention healing
• Conclusions
• Acknowledgment
• References

11. Biological Agents and Cell Therapies in Periodontal Regeneration
Hannu Larjava, Yi Yang, Edward Putnins, Jyrki Heino, and Lari Häkkinen

• Introduction
• Adjunct growth factors in periodontal wound repair
• PDGF and IGF-1 in periodontal regeneration
• Platelet-rich plasma in periodontal therapy
• FGF-2 in periodontal regeneration
• Growth and differentiation factor-5 in periodontal regeneration
• Other growth factors in periodontal regeneration
• Bioactive collagen-derived peptide in periodontal regeneration (PepGen P-15®)
• Enamel matrix proteins in periodontal regeneration and wound healing
• Stem cells in periodontal wound healing
• Conclusions
• References

12. Wound Healing Around Dental Implants
Cristina Cunha Villar, Guy Huynh-Ba, Michael P. Mills, and David L. Cochran

• Introduction
• Historical development
• Titanium – the metal of choice
• Healing following implant placement
• Peri-implant soft tissue healing
• Implant/peri-implant mucosa interface
• Peri-implant hard tissue healing
• From healing to clinical application
• Implant stability testing
• Wound healing and loading protocols
• Conclusions
• References

13. The Pulp Healing Process: From Generation to Regeneration
Stéphane Simon, Anthony J. Smith, Philip J. Lumley, Paul R. Cooper, and Ariane Berdal

• From generation to regeneration
• At the molecular level
• Conclusion
• References

14. Dermal Wound Healing and Burn Wounds
Anthony Papp

• Introduction
• Burn injury
• Skin anatomy
• Burn depth
• Wound healing
• Treatment
• Special features in perioral burns
• Conclusions
• References

15. Healing of Large Dentofacial Defects
George K.B. Sándor, Robert P. Carmichael, Leena P. Ylikontiola, Ahmed Jan, Marc G. DuVal, and Cameron M.L. Clokie

• Introduction
• The need for bone
• Bone healing
• Surgical maneuvers to induce and promote healing of large defects
• Specifically difficult wounds
• Conclusions

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