Cellular Signal Transduction in Toxicology and Pharmacology Data Collection Analysis and Interpretation 1st Edition by Jonathan Boyd 1119060265 9781119060260

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Product details:

ISBN 10: 1119060265

ISBN 13: 9781119060260

Author: Jonathan W. Boyd

Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques

Cellular Signal Transduction in Toxicology and Pharmacology Data Collection Analysis and Interpretation 1st Table of contents:

1 Introduction to Cellular Signal Transduction

1.1 Starting Big, but Ending Small

1.2 Responding to Our Environment: Sensory Perception Begins and Ends with Signal Transduction

1.3 Primary Transport Systems Involved in Signal Transduction

1.4 Key Organelles Involved in Signal Transduction

References

2 Mechanisms of Cellular Signal Transduction

2.1 Posttranslational Modifications and Their Roles in Signal Transduction

2.2 Receptors

2.3 Receptor Signaling Mechanisms

2.4 Receptor Tyrosine Kinases

2.5 Steroid Receptors

2.6 Reactive Oxygen Species (ROS)

2.7 Summary

References

3 From Cellular Mechanisms to Physiological Responses

3.1 Introduction

3.2 Cellular Information Flow: Mechanisms of Cellular Signal Integration and Regulation

3.3 Crosstalk and Functional Signal Integration in Response to Insulin in Hepatocytes

3.4 Systemic Signal Integration

3.5 Dysregulation of Insulin Signaling in the Etiology of Type 2 Diabetes

References

4 Signal Transduction in Disease

4.1 Introduction

4.2 Fibrosis as an Example of Complex Signaling

4.3 Cancer Drug Resistance: Complex Cellular and Population Changes

4.4 Summary

References

5 Experimental Design in Signal Transduction

5.1 Overview of Basic Experimental Design

5.2 Aseptic Technique

5.3 Biological Sample Collection, Processing, and Pretreatment Technology

5.4 Sample Storage

5.5 Common In Vitro Studies in Toxicology/Pharmacology

5.6 Common In Vivo Studies in Toxicology

5.7 Basic Advantages and Disadvantages Associated with Sample Types

5.8 Human Epidemiology Studies

5.9 Examples of Tox‐ and Pharm‐Based Experiments Relevant to Signal Transduction Endpoints

5.10 Coupling Experimental Results Within the Larger Literature Framework to Generate Information

References

6 Techniques for Measuring Cellular Signal Transduction

6.1 Introduction

6.2 High‐Throughput Versus High‐Content Data

6.3 Methods to Measure Signal Transduction Data

6.4 Techniques to Generate Large Datasets for Signal Transduction Network Analysis

6.5 Bioenergetics

6.6 Relating Signaling to Cellular Outcome Using Relevant Assays

6.7 Summary

References

Suggested Reading

7 Computational Methods for Signal Transduction

7.1 Introduction

7.2 Network Construction

7.3 Facing the Network Analysis

7.4 Employing Centrality Analysis to Evaluate Stressed Biological Systems

7.5 Interference Notion: How to Perform Virtual Knockout Experiments on Biological Networks

7.6 Network Analysis Software

7.7 Conclusions

References

8 A Toxicological Application of Signal Transduction

8.1 Introduction

8.2 Classification of Toxic Agent and Exposure Effects: A Toxicological Perspective

8.3 Early Cellular Changes Post‐exposure

8.4 Experimentally Testing Early Cellular Changes that May Contribute to Exposure Sensing and Response

References

Appendix A

9 Future Research in Signaling

9.1 Translational Research and a Spatiotemporal Understanding of Signal Transduction

9.2 Integrating Second Messengers into Signal Transduction

9.3 Understanding Crosstalk in Signal Transduction

9.4 Posttranslational Modifications (PTMs) and Target Identification in Signal Transduction

9.5 Epigenetic Endpoints in Signal Transduction

9.6 The Integration of Nutrition and Signal Transduction

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