Fundamental Biomechanics in Bone Tissue Engineering 1st edition by Xiaodu Wang, Jeffrey Nyman, Xuanliang Dong, Huijie Leng, Michael Reyes – Ebook PDF Instant Download/DeliveryISBN: 3031025792, 9783031025792
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ISBN-10 : 3031025792
ISBN-13 : 9783031025792
Author : Xiaodu Wang, Jeffrey Nyman, Xuanliang Dong, Huijie Leng, Michael Reyes
This eight-chapter monograph intends to present basic principles and applications of biomechanics in bone tissue engineering in order to assist tissue engineers in design and use of tissue-engineered products for repair and replacement of damaged/deformed bone tissues. Briefly, Chapter 1 gives an overall review of biomechanics in the field of bone tissue engineering. Chapter 2 provides detailed information regarding the composition and architecture of bone. Chapter 3 discusses the current methodologies for mechanical testing of bone properties (i.e., elastic, plastic, damage/fracture, viscoelastic/viscoplastic properties). Chapter 4 presents the current understanding of the mechanical behavior of bone and the associated underlying mechanisms. Chapter 5 discusses the structure and properties of scaffolds currently used for bone tissue engineering applications. Chapter 6 gives a brief discussion of current mechanical and structural tests of repair/tissue engineered bone tissues. Chapter 7 summarizes the properties of repair/tissue engineered bone tissues currently attained. Finally, Chapter 8 discusses the current issues regarding biomechanics in the area of bone tissue engineering. Table of Contents: Introduction / Bone Composition and Structure / Current Mechanical Test Methodologies / Mechanical Behavior of Bone / Structure and Properties of Scaffolds for Bone Tissue Regeneration / Mechanical and Structural Evaluation of Repair/Tissue Engineered Bone / Mechanical and Structural Properties of Tissues Engineered/Repair Bone / Current Issues of Biomechanics in Bone Tissue Engineering
Fundamental Biomechanics in Bone Tissue Engineering 1st Table of contents:
- Introduction
- Bone Architecture
- Cortical Bone
- Trabecular Bone
- Differences Between Anatomical Locations, Ages, and Genders
- Ultrastructure/Composition of Bone
- Ultrastructure of Bone
- Constituents of Bone
- Differences Between Anatomical Locations, Ages, and Genders
- Differences Between Species
- Differences in Tissue Architecture
- Differences in Tissue Composition/Ultrastructure
- Summary
- Bibliography
- Current Mechanical Test Methodologies
- Chapter Summary
- Introduction
- Definition of Mechanical Properties
- Basic Concepts of Mechanics of Materials
- Elasticity
- Post-Yield Properties
- Failure
- Fatigue
- Viscoelasticity
- Mechanical Testing of Bulk Bone Tissues
- Tensile/Compressive Test
- Torsion (Shear) Test
- 3-Point and 4-Point Bending Test
- Progressive Loading
- Fracture Toughness Test
- Charpy and Izod Impact Tests
- Fatigue Test
- Viscoelastic Test
- Micro-Mechanical Testing Methodologies
- Nano-Indentation Methodologies
- Bibliography
- Mechanical Behavior of Bone
- Chapter Summary
- Introduction
- Mechanical Properties of Whole Bone
- Mechanical Properties of Bone at the Macroscopic Level
- Elastic Properties of Cortical and Trabecular Macroscopic Bone
- Post-Yield Properties of Cortical and Trabecular Macroscopic Bone
- Fracture Toughness of Cortical and Trabecular Macroscopic Bone
- Viscoelastic Behavior of Cortical and Trabecular Macroscopic Bone
- Fatigue Behavior of Cortical and Trabecular Macroscopic Bone
- Mechanical Properties of Bone at the Microscopic Level
- Elastic Properties of Cortical and Trabecular Microscopic Bone
- Post-Yield Behavior of Cortical and Trabecular Microscopic Bone
- Mechanical Properties of Bone at the Sub-Microscopic Level
- Mechanical Properties of Hydroxyapatite and Collagen
- Physiological Response of Bone to Functional Loading
- Concluding Remarks
- Bibliography
- Structure and Properties of Scaffolds for Bone Tissue Regeneration
- Chapter Summary
- Introduction
- Synthetic Polymers
- Determinants of the Mechanical Properties of Synthetic Polymers
- Examples of Synthetic Polymers for Bone Regeneration
- Determinants of the Mechanical Properties of Naturally derived Polymers
- Examples of Naturally derived Polymers for Bone Regeneration
- Bioceramics
- Determinants of the Mechanical Properties of Ceramics
- Examples of Ceramics for Bone Regeneration
- Examples of Ceramic-Polymer Composites for Bone Regeneration
- Metals
- Determinants of the Mechanical Properties of Metals
- Examples of Metals for Bone Regeneration
- Structural Requirements for Functional Scaffolds
- The Balance Between Scaffold Degradation and Tissue Regeneration
- Determinants of Degradation
- Conclusion
- Bibliography
- Mechanical and Structural Evaluation of Repair/Tissue Engineered Bone
- Chapter Summary
- Introduction
- In Vitro Biomechanical Evaluation of Fracture Repair
- Torsional Test
- Bending
- Tension
- Compression
- Micro/Nano Indentation Tests
- In Vivo Stiffness Monitoring of Healing Bone
- Non-Invasive Measurement of Fracture Healing
- X-Ray (Plain Radiography)
- Dual-Energy X-Ray Absorptiometry (DEXA)
- Computed Tomography (CT) and Quantitative Computed Tomography (QCT)
- Micro Computed Tomography (Micro-CT)
- Numerical Evaluation of Fracture Healing
- Summary
- Bibliography
- Mechanical and Structural Properties of Tissues Engineered/Repair Bone
- Chapter Summary
- Introduction
- Biological Stages of Fracture Healing
- Inflammation
- Soft Tissue Repair
- Calcified Cartilage Fusing the Fracture Gap
- Remodeling of the Callus
- Intramembranous Bone Formation in the Critical Sized Defect
- Biomechanical Properties of Repair/Tissue Engineered Bone
- Torsional Properties
- Bending Properties
- Tensile Properties
- Compressive Properties of Fracture Callus
- Biomechanical Properties of Tissue Engineered Bone
- Summary
- Bibliography
- Current Issues of Biomechanics in Bone Tissue Engineering
- Chapter Summary
- Introduction
- Ideal Scaffold System for Bone Tissue Engineering
- Functional Architecture of Scaffold
- Non Biodegradable Scaffolds
- Biodegradable Scaffolds
- Osteoinductivity/Osteoconductivity
- Mechanical Environment
- Bioreactor: Biomimetic Environment for Bone Formation
- Cell Seeding
- Mass Transport
- Physical Conditioning
- Biological/Biochemical Environment
- Mechanobiology in Bone Tissue Engineering
- Mechanobiology
- Mechanosensation
- Mechanotransduction
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