Cancer pharmacology an illustrated manual of anticancer drugsn 1st Edition by Ashkan Emadi, Judith Karp ISBN 0826162037 9780826162038

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Product details:
ISBN 10: 0826162037
ISBN 13: 9780826162038
Author: Ashkan Emadi, Judith Karp

Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this pharmacology book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies.

Beautifully illustrated throughout, each chapter in this cancer pharmacology guide contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more.

Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easy-to-digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to oncology pharmacotherapy.

Cancer pharmacology an illustrated manual of anticancer drugsn 1st Edition Table of contents:

Part I: Introduction to Cancer and Cancer Pharmacology

1. Understanding Cancer: Biology and Pathophysiology

   • Cancer Cell Biology: Hallmarks of Cancer
   • Genetic Mutations and Tumorigenesis
   • Tumor Microenvironment and Angiogenesis
   • Metastasis and Cancer Progression

2. Principles of Cancer Pharmacology

   • The Drug Discovery Process in Oncology
   • Pharmacokinetics and Pharmacodynamics of Anticancer Drugs
   • Mechanisms of Drug Resistance in Cancer Cells
   • Challenges in Cancer Drug Development
   • Strategies to Overcome Drug Resistance

3. Cancer Treatment Modalities

   • Surgery, Radiation, and Chemotherapy
   • Targeted Therapy and Immunotherapy
   • Hormone Therapy and Gene Therapy
   • Personalized Medicine and Precision Oncology

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Part II: Chemotherapy Agents and Their Mechanisms of Action

4. Alkylating Agents

   • Mechanisms of Action and Cellular Targets
   • Key Drugs: Cyclophosphamide, Melphalan, Busulfan
   • Clinical Applications and Side Effects
   • Resistance Mechanisms and Overcoming Resistance

5. Antimetabolites

   • Mechanisms of Action: Inhibition of DNA/RNA Synthesis
   • Key Drugs: Methotrexate, 5-Fluorouracil, Gemcitabine
   • Clinical Indications and Toxicities
   • Resistance Mechanisms and Drug Modifications

6. Natural Products and Plant-Derived Agents

   • Microtubule-Targeting Agents: Taxanes, Vinca Alkaloids
   • Topoisomerase Inhibitors: Etoposide, Topotecan
   • Clinical Applications and Side Effects
   • Mechanisms of Drug Resistance

7. Antitumor Antibiotics

   • Mechanisms of Action and Cellular Targets
   • Key Drugs: Doxorubicin, Bleomycin, Mitomycin
   • Clinical Applications and Toxicities
   • Resistance Mechanisms in Antitumor Antibiotics

8. Platinum-Based Agents

   • Mechanisms of Action and Cellular Targets
   • Key Drugs: Cisplatin, Carboplatin, Oxaliplatin
   • Clinical Applications in Solid Tumors
   • Side Effects and Resistance Mechanisms

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Part III: Targeted and Immunotherapy Drugs

9. Targeted Therapy: Mechanisms and Agents

   • Targeting Oncogenes and Tumor Suppressors
   • Key Drugs: Imatinib (Gleevec), Erlotinib, Lapatinib
   • Tyrosine Kinase Inhibitors in Cancer Treatment
   • Resistance Mechanisms in Targeted Therapy

10. Monoclonal Antibodies in Cancer Treatment

    • Mechanisms of Action of Antibodies in Oncology
    • Key Drugs: Rituximab, Trastuzumab, Cetuximab
    • Clinical Applications in Hematologic and Solid Tumors
    • Side Effects and Resistance Mechanisms

11. Immune Checkpoint Inhibitors

    • PD-1/PD-L1 and CTLA-4 Pathways in Cancer Immunotherapy
    • Key Drugs: Nivolumab, Pembrolizumab, Ipilimumab
    • Applications in Melanoma, Lung Cancer, and Other Tumors
    • Immune-Related Adverse Effects

12. CAR T-Cell Therapy and Gene-Based Approaches

    • CAR-T Cells: Mechanisms and Applications
    • Gene Therapy in Cancer: Current Status and Challenges
    • Future Directions in Immunotherapy

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Part IV: Hormonal and Biological Therapy

13. Hormone Therapy in Cancer Treatment

    • Mechanisms of Action: Estrogen and Androgen Blockade
    • Key Drugs: Tamoxifen, Anastrozole, Leuprolide
    • Clinical Use in Breast, Prostate, and Endometrial Cancer
    • Side Effects and Resistance Mechanisms

14. Biologic Therapy: Cytokines and Growth Factors

    • Mechanisms of Action: Interferons, Interleukins, and Colony-Stimulating Factors
    • Key Drugs: Interferon-alpha, G-CSF, Erythropoietin
    • Clinical Applications and Toxicities

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Part V: Combination Therapies and Future Directions

15. Combination Chemotherapy: Rational and Practice

    • Principles of Combination Therapy in Cancer
    • Synergistic and Non-Synergistic Drug Combinations
    • Clinical Guidelines and Protocols for Combination Therapy
    • Managing Side Effects and Toxicities in Combination Regimens

16. Emerging Therapies in Cancer Pharmacology

    • Novel Drug Classes: Epigenetic Modifiers, Prodrug Strategies
    • Advances in Nanotechnology for Drug Delivery
    • The Role of Artificial Intelligence in Drug Discovery
    • Immunotherapy Combinations and New Targeted Approaches

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Part VI: Clinical Considerations and Supportive Care

17. Pharmacological Management of Cancer Side Effects

    • Managing Chemotherapy-Induced Nausea and Vomiting
    • Pain Management in Cancer Treatment
    • Bone Marrow Suppression and Growth Factors
    • Targeted Therapies and Their Unique Side Effects

18. Pharmacogenomics in Cancer Treatment

    • The Role of Genetic Profiling in Drug Response
    • Personalized Oncology: Tailoring Therapy Based on Genetic Information
    • Clinical Applications of Pharmacogenomics in Cancer Treatment

19. Clinical Trials and Drug Development in Oncology

    • The Drug Development Process in Cancer Research
    • Regulatory Aspects and Approval of Cancer Drugs
    • Clinical Trials in Oncology: Design, Ethics, and Challenges
    • Case Studies in Cancer Drug Development

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