The Kappa Opioid Receptor 1st edition by Lee Yuan Liu Chen,Saadet Inan – Ebook PDF Instant Download/Delivery.9783030890742,3030890740
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ISBN 10: 3030890740
ISBN 13: 9783030890742
Author:Lee Yuan Liu Chen,Saadet Inan
This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials.
The chapters “Biosensors monitor ligand-selective effects at kappa opioid receptors” and “The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach” of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
The Kappa Opioid Receptor 1st Table of contents:
Part I. Basics
Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and Function
Considerations on Using Antibodies for Studying the Dynorphins/Kappa Opioid Receptor System
Part II. In Vitro Studies
Structural Characterization of KOR Inactive and Active States for 3D Pharmacology and Drug Discovery
Biosensors Monitor Ligand-Selective Effects at Kappa Opioid Receptors
Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) via Its Ability to Interact with NSF Directly?
Kappa Opioid Receptor Mediated Differential Regulation of Serotonin and Dopamine Transporters in Mood and Substance Use Disorder
Part III. Preclinical Drug Development
Biased Ligands at the Kappa Opioid Receptor: Fine-Tuning Receptor Pharmacology
Preclinical Studies on Nalfurafine (TRK-820), a Clinically Used KOR Agonist
Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands
Peptide Kappa Opioid Receptor Ligands and Their Potential for Drug Development
Part IV. Preclinical Studies: In Vivo Pharmacology
Dynorphin/Kappa-Opioid Receptor System Modulation of Cortical Circuitry
Molecular Genetics of Kappa Opioids in Pain and Itch Sensations
Antipruritic Effects of Kappa Opioid Receptor Agonists: Evidence from Rodents to Humans
Antinociceptive Effects of Kappa-Opioid Receptor Agonists
Kappa Opioid Signaling at the Crossroads of Chronic Pain and Opioid Addiction
KOR Control over Addiction Processing: An Exploration of the Mesolimbic Dopamine Pathway
The Kappa Opioid Receptor System in Temporal Lobe Epilepsy
Kappa Opioid Agonist-Induced Diuresis: Characteristics, Mechanisms, and Beyond
Kappa Opioid Receptor Expression and Function in Cells of the Immune System
Pleiotropic Effects of Kappa Opioid Receptor-Related Ligands in Non-human Primates
Part V. Clinical Studies and Concepts
Clinical Profiles of Nalfurafine Hydrochloride for the Treatment of Pruritus Patients
Kappa Opioid Receptor Antagonists as Potential Therapeutics for Mood and Substance Use Disorders
Kappa Opioid Receptors in the Pathology and Treatment of Major Depressive Disorder
The Role of Dynorphin and the Kappa Opioid Receptor in Schizophrenia and Major Depressive Disorder: A Translational Approach
Imaging Kappa Opioid Receptors in the Living Brain with Positron Emission Tomography
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