Physiology Pharmacology and Pathology of the Blood Brain Barrier 1st edition by Zameel Cader,Winfried Neuhaus 3030996549 9783030996543

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ISBN 10: 3030996549

ISBN 13: 9783030996543

Author:Zameel Cader,Winfried Neuhaus

This book presents a comprehensive collection of current knowledge and leading research about the blood-brain barrier. The chapters are organized in four main parts providing basic information and novel insights about the physiology of the blood-brain barrier, the challenges related to finding and developing drugs crossing the blood-brain barrier, experimental methods to study the blood-brain barrier and the role of the blood-brain barrier in disease mechanisms and its consequences for drug development. In the first part the readers will discover the structure, function and developmental aspects of the blood-brain barrier and gain novel insights into the complexity and functionality of the neurovascular unit and energy metabolism of brain endothelial cells. Chapters of the second part focus on translational challenges from the bench to the bedside in CNS drug development, shed light on the importance to understand the brain distribution of drugs related to their efficacy, elaborate on general pharmacokinetic considerations for CNS drugs and introduce current and novel drug delivery strategies to overcome the blood-brain barrier. The experimental part of the book covers mathematical and in vitro models as well as animal and human methods in blood-brain barrier research. Specific emphasis is set on the description of the methods, the role of species differences for data interpretation, novel human models based on stem cells with the potential for personalized medicine and technical considerations and tips helpful for readers interested in working with these models. In the fourth part particular attentions is given to the blood-brain barrier, its changes and participation during disease progression. Chapters summarize alterations of the blood-brain barrier that are present in common disorders such as Alzheimer’s disease, multiple sclerosis, stroke, traumatic brain injury, epilepsy and brain tumors. Present therapies will be discussed and the consequences for novel treatment approaches that need to bypass the blood-brain-barrier will be explored. In addition, experts discuss the question in how far changes at the blood-brain barrier are causally linked to disease progressions and consequently could serve as therapeutic targets. This collection is designed to appeal to a wide readership from students through basic and applied scientist to pharmacologists, medical doctors and stakeholders from the pharmaceutical industry and regulatory affairs. Due its comprehensive content the book has the potential to become a standard work in the field of blood-brain barrier research.

Physiology Pharmacology and Pathology of the Blood Brain Barrier 1st  Table of contents: 

Part I. Background on the Blood-Brain Barrier

Structure and Function of the Blood–Brain Barrier (BBB)

New Insights in the Complexity and Functionality of the Neurovascular Unit

Brain Endothelial Cells: Metabolic Flux and Energy Metabolism

Part II. Challenges with Findings Drugs to Cross the Blood-Brain Barrier

Considerations When Developing Blood–Brain Barrier Crossing Drug Delivery Technology

Brain Distribution of Drugs: Brain Morphology, Delivery Routes, and Species Differences

Brain Distribution of Drugs: Pharmacokinetic Considerations

Drug Delivery Strategies to Overcome the Blood–Brain Barrier (BBB)

Part III. Experimental Methods to Study Drug Transport across the Blood-Brain Barrier In Vitro and In Vivo

Transport Studies Using Blood-Brain Barrier In Vitro Models: A Critical Review and Guidelines

Human Blood-Brain-Barrier In Vitro Models: Overview and Applications

In Vivo Studies of Drug BBB Transport: Translational Challenges and the Role of Brain Imaging

Part IV. The Blood-Brain Barrier and Diseases: Novel Treatment Approaches from a Blood-Brain Barrier Perspective

The Blood-Brain Barrier in Alzheimer’s Disease

Blood–Brain Barrier Mechanisms in Stroke and Trauma

Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective

Epilepsy and Alterations of the Blood–Brain Barrier: Cause or Consequence of Epileptic Seizures or Both?

Novel Treatment Approaches for Brain Tumour from a Blood–Brain Barrier Perspective

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